DR LADAME

Rankin S, Reszka AP, Huppert J, Zloh M, Parkinson GN, Todd AK, Ladame S, Balasubramanian S, Neidle Set al., 2005, Putative DNA quadruplex formation within the human <i>c-kit</i> oncogene, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Vol: 127, Pages: 10584-10589, ISSN: 0002-7863

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• Citations: 492

Ladame S, Fauré R, Denier C, Lakhdar-Ghazal F, Willson MEet al., 2005, Selective inhibition of <i>Trypanosoma cruzi</i> GAPDH by "bi-substrate" analogues, ORGANIC & BIOMOLECULAR CHEMISTRY, Vol: 3, Pages: 2070-2072, ISSN: 1477-0520

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• Citations: 11

Ladame S, Whitney AM, Balasubramanian S, 2005, Targeting nucleic acid secondary structures with polyamides using an optimized dynamic combinatorial approach, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, Vol: 44, Pages: 5736-5739, ISSN: 1433-7851

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• Citations: 47

Patel SD, Isalan M, Gavory G, Ladame S, Choo Y, Balasubramanian Set al., 2004, Inhibition of human telomerase activity by an engineered zinc finger protein that binds G-quadruplexes, BIOCHEMISTRY, Vol: 43, Pages: 13452-13458, ISSN: 0006-2960

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• Citations: 43

Ladame S, Schouten JA, Stuart J, Roldan J, Neidle S, Balasubramanian Set al., 2004, Tetrapeptides induce selective recognition for G-quadruplexes when conjugated to a DNA-binding platform, ORGANIC & BIOMOLECULAR CHEMISTRY, Vol: 2, Pages: 2925-2931, ISSN: 1477-0520

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• Citations: 34

Whitney AM, Ladame S, Balasubramanian S, 2004, Templated ligand assembly by using G-quadruplex DNA and dynamic covalent chemistry, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, Vol: 43, Pages: 1143-1146, ISSN: 1433-7851

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• Citations: 64

Ladame S, Castilho MS, Silva CHTP, Denier C, Hannaert V, Périé J, Oliva G, Willson Met al., 2003, Crystal structure of <i>Trypanosoma cruzi</i> glyceraldehyde-3-phosphate dehydrogenase complexed with an analogue of 1,3-bisphospho-D-glyceric acid -: Selective inhibition by structure-based design, EUROPEAN JOURNAL OF BIOCHEMISTRY, Vol: 270, Pages: 4574-4586, ISSN: 0014-2956

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• Citations: 36

Ladame S, Castilho MS, Silva CHTP, Denier C, Hannaert V, Périé J, Oliva G, Willson Met al., 2003, Crystal structure of Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase complexed with an analogue of 1,3-bisphospho-d-glyceric acid., Eur J Biochem, Vol: 270, Pages: 4574-4586, ISSN: 0014-2956

We report here the first crystal structure of a stable isosteric analogue of 1,3-bisphospho-d-glyceric acid (1,3-BPGA) bound to the catalytic domain of Trypanosoma cruzi glycosomal glyceraldehyde-3-phosphate dehydrogenase (gGAPDH) in which the two phosphoryl moieties interact with Arg249. This complex possibly illustrates a step of the catalytic process by which Arg249 may induce compression of the product formed, allowing its expulsion from the active site. Structural modifications were introduced into this isosteric analogue and the respective inhibitory effects of the resulting diphosphorylated compounds on T. cruzi and Trypanosoma brucei gGAPDHs were investigated by enzymatic inhibition studies, fluorescence spectroscopy, site-directed mutagenesis, and molecular modelling. Despite the high homology between the two trypanomastid gGAPDHs (> 95%), we have identified specific interactions that could be used to design selective irreversible inhibitors against T. cruzi gGAPDH.

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Castilho MS, Paváo F, Oliva G, Ladame S, Willson M, Périé Jet al., 2003, Evidence for the two phosphate binding sites of an analogue of the thioacyl intermediate for the <i>Trypanosoma cruzi</i> glyceraldehyde-3-phosphate dehydrogenase-catalyzed reaction, from its crystal structure, BIOCHEMISTRY, Vol: 42, Pages: 7143-7151, ISSN: 0006-2960

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• Citations: 39

Schouten JA, Ladame S, Mason SJ, Cooper MA, Balasubramanian Set al., 2003, G-quadruplex-specific peptide-hemicyanine ligands by partial combinatorial selection, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Vol: 125, Pages: 5594-5595, ISSN: 0002-7863

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• Citations: 60

Ladame S, Willson M, Périé J, 2002, A convenient synthesis of dibenzyl α,α-difluoromethyl-β-ketophosphonates, EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, Vol: 2002, Pages: 2640-2648, ISSN: 1434-193X

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• Citations: 12

Ladame S, Harrison RJ, Neidle S, Balasubramanian Set al., 2002, Solid-phase synthesis of symmetrical 3,6-bispeptide-acridone conjugates, ORGANIC LETTERS, Vol: 4, Pages: 2509-2512, ISSN: 1523-7060

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• Citations: 13

Ladame S, Bardet M, Périé J, Willson Met al., 2001, Selective inhibition of <i>Trypanosoma brucei</i> GAPDH by 1,3-bisphospho-D-glyceric acid (1,3-diPG) analogues, BIOORGANIC & MEDICINAL CHEMISTRY, Vol: 9, Pages: 773-783, ISSN: 0968-0896

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• Citations: 11

Ladame S, Claustre S, Willson M, 2001, Selective phosphorylation on primary alcohols of unprotected polyols, PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, Vol: 174, Pages: 37-47, ISSN: 1042-6507

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• Citations: 10

Nzita L, Ladame S, Gomez L, Moreau Set al., 1997, Synthesis of a 2-hydroxy-oxolane derivative as a new potential crosslinking agent of DNA, XII International Round Table on Nucleosides, Nucleotides and their Biological Applications - Making Drugs Out of Nucleosides and Oligonucleotides, Publisher: MARCEL DEKKER INC, Pages: 1781-1784, ISSN: 0732-8311

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• Citations: 1