Publications
75 results found
Zuffo M, Doria F, Spalluto V, et al., 2015, Red/NIR G-Quadruplex Sensing, Harvesting Blue Light by a Coumarin-Naphthalene Diimide Dyad, CHEMISTRY-A EUROPEAN JOURNAL, Vol: 21, Pages: 17596-17600, ISSN: 0947-6539
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- Citations: 27
Choi Y, Metcalf G, Haj Sleiman M, et al., 2014, Oligonucleotide-templated reactions based on Peptide Nucleic Acid (PNA) probes: Concept and biomedical applications., Bioorganic and Medicinal Chemistry
Sensing technologies based on Peptide Nucleic Acids (PNAs) and oligonucleotide-templated chemistry are perfectly suited for biomedical applications (e.g., diagnosis, prognosis and stratification of diseases) and could compete well with more traditional amplification technologies using expensive dual-labelled oligonucleotide probes. PNAs can be easily synthesised and functionalised, are more stable and are more responsive to point-mutations than their DNA counterpart. For these reasons, fluorogenic PNAs represent an interesting alternative to DNA-based molecular beacons for sensing applications in a cell-free environment, where cellular uptake is not required.
Fallah-Araghi A, Meguellati K, Baret J-C, et al., 2014, Enhanced Chemical Synthesis at Soft Interfaces: A Universal Reaction-Adsorption Mechanism in Microcompartments, PHYSICAL REVIEW LETTERS, Vol: 112, ISSN: 0031-9007
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- Citations: 174
Sleiman MH, Ladame S, 2014, Synthesis of squaraine dyes under mild conditions: applications for labelling and sensing of biomolecules, CHEMICAL COMMUNICATIONS, Vol: 50, Pages: 5288-5290, ISSN: 1359-7345
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- Citations: 14
Najah M, Mayot E, Mahendra-Wijaya IP, et al., 2013, New Glycosidase Substrates for Droplet-Based Microfluidic Screening, ANALYTICAL CHEMISTRY, Vol: 85, Pages: 9807-9814, ISSN: 0003-2700
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- Citations: 51
Percivalle C, Mahmood T, Ladame S, 2013, Two-in-one: a pH-sensitive, acridine-based, fluorescent probe binds G-quadruplexes in oncogene promoters, MEDCHEMCOMM, Vol: 4, Pages: 211-215, ISSN: 2040-2503
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- Citations: 16
Percivalle C, Bartolo J-F, Ladame S, 2013, Oligonucleotide-templated chemical reactions: pushing the boundaries of a nature-inspired process, ORGANIC & BIOMOLECULAR CHEMISTRY, Vol: 11, Pages: 16-26, ISSN: 1477-0520
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- Citations: 44
Meguellati K, Fallah-Araghi A, Baret J-C, et al., 2013, Enhanced imine synthesis in water: from surfactant-mediated catalysis to host-guest mechanisms, CHEMICAL COMMUNICATIONS, Vol: 49, Pages: 11332-11334, ISSN: 1359-7345
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- Citations: 16
Mahmood T, Wu Y, Loriot D, et al., 2012, Closing the ring to bring up the light: synthesis of a hexacyclic acridinium cyanine dye., Chemistry, Vol: 18, Pages: 12349-12356
The synthesis of a geometrically constrained and near-planar hexacyclic acridinium cyanine dye 9 is reported. When compared to its unlocked and non-fluorescent monomethine cyanine dye analogue 3, this photostable dye emits in the green area of the spectrum with a remarkable quantum yield close to unity in organic solvents and above 0.5 in water. A detailed steady-state and time-resolved spectroscopic study revealed that dye 9 forms emissive aggregates in water, which are responsible for a red-shifted and broadened emission band and longer emission lifetime, τ≈33 compared to 6.5-7.0 ns for the monomeric dye. Dye 9 also binds strongly to DNA (both duplex and quadruplex) in its monomeric form and is very efficiently taken up by cells, in which it accumulates primarily into the nucleus.
Meguellati K, Ladame S, 2012, Reversible Covalent Chemistries Compatible with the Principles of Constitutional Dynamic Chemistry: New Reactions to Create More Diversity, CONSTITUTIONAL DYNAMIC CHEMISTRY, Vol: 322, Pages: 291-314, ISSN: 0340-1022
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- Citations: 18
Meguellati K, Ladame S, Spichty M, 2011, A conceptually improved TD-DFT approach for predicting the maximum absorption wavelength of cyanine dyes, DYES AND PIGMENTS, Vol: 90, Pages: 114-118, ISSN: 0143-7208
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- Citations: 26
Koripelly G, Meguellati K, Ladame S, 2010, Dual Sensing of Hairpin and Quadruplex DNA Structures Using Multicolored Peptide Nucleic Acid Fluorescent Probes, BIOCONJUGATE CHEMISTRY, Vol: 21, Pages: 2103-2109, ISSN: 1043-1802
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- Citations: 30
Mahmood T, Paul A, Ladame S, 2010, Synthesis and Spectroscopic and DNA-Binding Properties of Fluorogenic Acridine-Containing Cyanine Dyes, JOURNAL OF ORGANIC CHEMISTRY, Vol: 75, Pages: 204-207, ISSN: 0022-3263
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- Citations: 51
Meguellati K, Spichty M, Ladame S, 2010, Synthesis, spectroscopic and DNA alkylating properties of malondialdehyde (MDA) <i>bis</i>-imine fluorescent adducts, MOLECULAR BIOSYSTEMS, Vol: 6, Pages: 1694-1699, ISSN: 1742-206X
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- Citations: 3
Meguellati K, Koripelly G, Ladame S, 2010, DNA-Templated Synthesis of Trimethine Cyanine Dyes: A Versatile Fluorogenic Reaction for Sensing G-Quadruplex Formation, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, Vol: 49, Pages: 2738-2742, ISSN: 1433-7851
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- Citations: 86
Paul A, Ladame S, 2009, 9-Amino Acridines Undergo Reversible Amine Exchange Reactions in Water: Implications on Their Mechanism of Action in Vivo, ORGANIC LETTERS, Vol: 11, Pages: 4894-4897, ISSN: 1523-7060
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- Citations: 23
Meguellati K, Spichty M, Ladame S, 2009, Reversible Synthesis and Characterization of Dynamic Imino Analogues of Trimethine and Pentamethine Cyanine Dyes, ORGANIC LETTERS, Vol: 11, Pages: 1123-1126, ISSN: 1523-7060
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- Citations: 21
Redman JE, Granadino-Roldan JM, Schouten JA, et al., 2009, Recognition and discrimination of DNA quadruplexes by acridine-peptide conjugates, ORGANIC & BIOMOLECULAR CHEMISTRY, Vol: 7, Pages: 76-84, ISSN: 1477-0520
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- Citations: 48
Soldatenkov VA, Vetcher AA, Duka T, et al., 2008, First evidence of a functional ineraction between DNA quadruplexes and poly(ADP-ribose) polymerase-1, ACS CHEMICAL BIOLOGY, Vol: 3, Pages: 214-219, ISSN: 1554-8929
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- Citations: 62
Paul A, Sengupta P, Krishnan Y, et al., 2008, Combining G-Quadruplex Targeting Motifs on a Single Peptide Nucleic Acid Scaffold: A Hybrid (3+1) PNA-DNA Bimolecular Quadruplex, CHEMISTRY-A EUROPEAN JOURNAL, Vol: 14, Pages: 8682-8689, ISSN: 0947-6539
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- Citations: 48
Ladame S, 2008, Dynamic combinatorial chemistry: on the road to fulfilling the promise, ORGANIC & BIOMOLECULAR CHEMISTRY, Vol: 6, Pages: 219-226, ISSN: 1477-0520
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- Citations: 201
Shirude PS, Gillies ER, Ladame S, et al., 2007, Macrocyclic and helical oligoamides as a new class of g-quadruplex ligands, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Vol: 129, Pages: 11890-+, ISSN: 0002-7863
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- Citations: 151
Shirude PS, Gillies E, Ladame S, et al., 2007, ORGN 41-Quinoline oligoamide macrocycle: Selective G quadruplex binding ligand, ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, Vol: 234, ISSN: 0065-7727
Jantos K, Rodriguez R, Ladame S, et al., 2006, Oxazole-based peptide macrocycles: A new class of G-quadruplex binding ligands, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Vol: 128, Pages: 13662-13663, ISSN: 0002-7863
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- Citations: 114
Green JJ, Ladame S, Ying L, et al., 2006, Investigating a quadruplex-ligand interaction by unfolding kinetics, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Vol: 128, Pages: 9809-9812, ISSN: 0002-7863
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- Citations: 30
Fernando H, Reszka AP, Huppert J, et al., 2006, A conserved quadruplex motif located in a transcription activation site of the human c-kit oncogene, BIOCHEMISTRY, Vol: 45, Pages: 7854-7860, ISSN: 0006-2960
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- Citations: 336
Ladame S, Schouten JA, Roldan J, et al., 2006, Exploring the recognition of quadruplex DNA by an engineered Cys<sub>2</sub>-His<sub>2</sub> zinc finger protein, BIOCHEMISTRY, Vol: 45, Pages: 1393-1399, ISSN: 0006-2960
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- Citations: 33
Redman JE, Ladame S, Reszka AP, et al., 2006, Discovery of G-quadruplex stabilizing ligands through direct ELISA of a one-bead-one-compound library, ORGANIC & BIOMOLECULAR CHEMISTRY, Vol: 4, Pages: 4364-4369, ISSN: 1477-0520
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- Citations: 11
Goncalves DPN, Ladame S, Balasubramanian S, et al., 2006, Synthesis and G-quadruplex binding studies of new 4-<i>N</i>-methylpyridinium porphyrins, ORGANIC & BIOMOLECULAR CHEMISTRY, Vol: 4, Pages: 3337-3342, ISSN: 1477-0520
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- Citations: 58
Azéma L, Ladame S, Lapeyre C, et al., 2005, Does phosphoryl protonation occurs in aqueous phosphoesters solutions, SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, Vol: 62, Pages: 287-292, ISSN: 1386-1425
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- Citations: 8
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