Imperial College London
Alternate

DR LADAME

Faculty of Engineering, Department of Bioengineering

Reader in Biosensor Development
 
 
 
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Contact

 

+44 (0)20 7594 5308s.ladame Website

 
 
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Location

 

U321ASir Michael Uren HubWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@inproceedings{Channon:2020,
author = {Channon, RB and Gillespie, P and Nazmul, Islam M and Meng, X and Chen, YC and O'Hare, D and Ladame, S},
pages = {476--477},
title = {Electrochemical oligonucleotide templated reactions},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - CPAPER
AB  - The biosensing of nucleic acids is an excellent approach for medical diagnosis, however established nucleic acid sensing technologies are typically limited by slow throughput, bulky equipment and the difficulty in achieving trace sensitivity with single nucleotide specificity. Here, we describe the first example of an electrochemical oligonucleotide templated reaction (EOTR). The target nucleic acid acts as a template for two probe-modified peptide nucleic acids. Reaction of the probe heads then generates an electrochemically active adduct. We couple EOTR with a lateral flow assay platform, towards developing a screening test for prostate cancer specific miRNA.
AU  - Channon,RB
AU  - Gillespie,P
AU  - Nazmul,Islam M
AU  - Meng,X
AU  - Chen,YC
AU  - O'Hare,D
AU  - Ladame,S
EP  - 477
PY  - 2020///
SP  - 476
TI  - Electrochemical oligonucleotide templated reactions
ER  -
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