Imperial College London
Alternate

DR LADAME

Faculty of Engineering, Department of Bioengineering

Reader in Biosensor Development
 
 
 
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Contact

 

+44 (0)20 7594 5308s.ladame Website

 
 
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Location

 

U321ASir Michael Uren HubWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Mahmood:2012:10.1002/chem.201200802,
author = {Mahmood, T and Wu, Y and Loriot, D and Kuimova, M and Ladame, S},
doi = {10.1002/chem.201200802},
journal = {Chemistry},
pages = {12349--12356},
title = {Closing the ring to bring up the light: synthesis of a hexacyclic acridinium cyanine dye.},
url = {http://dx.doi.org/10.1002/chem.201200802},
volume = {18},
year = {2012}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The synthesis of a geometrically constrained and near-planar hexacyclic acridinium cyanine dye 9 is reported. When compared to its unlocked and non-fluorescent monomethine cyanine dye analogue 3, this photostable dye emits in the green area of the spectrum with a remarkable quantum yield close to unity in organic solvents and above 0.5 in water. A detailed steady-state and time-resolved spectroscopic study revealed that dye 9 forms emissive aggregates in water, which are responsible for a red-shifted and broadened emission band and longer emission lifetime, τ≈33 compared to 6.5-7.0 ns for the monomeric dye. Dye 9 also binds strongly to DNA (both duplex and quadruplex) in its monomeric form and is very efficiently taken up by cells, in which it accumulates primarily into the nucleus.
AU  - Mahmood,T
AU  - Wu,Y
AU  - Loriot,D
AU  - Kuimova,M
AU  - Ladame,S
DO  - 10.1002/chem.201200802
EP  - 12356
PY  - 2012///
SP  - 12349
TI  - Closing the ring to bring up the light: synthesis of a hexacyclic acridinium cyanine dye.
T2  - Chemistry
UR  - http://dx.doi.org/10.1002/chem.201200802
UR  - http://www.ncbi.nlm.nih.gov/pubmed/22907584
VL  - 18
ER  -
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