Imperial College London

Prof. Sandro Macchietto

Faculty of EngineeringDepartment of Chemical Engineering

Professor of Process Systems Engineering



+44 (0)20 7594 6608s.macchietto Website




Mrs Sarah Payne +44 (0)20 7594 5567




ACEX 507aACE ExtensionSouth Kensington Campus





I am a Professor of Process Systems Engineering in the Department of Chemical Engineering at Imperial College London.

My research interests focus on the development of methods for modelling, simulation, control, optimisation and design of processes using an integrated systems approach, and their application to industrial fields, including sustainable energy systems.

I am also interested in the creation of innovative mechanisms for research, and promoting interfaces between academia and industry. At Imperial I co-founded and led in various positions, to director, the Interdisciplinary Centre for Process Systems Engineering (CPSE), a worldwide centre of excellence in its sector, co-founded and was a director of the Energy Futures Lab and launched the MSc in Sustainable Energy Futures, two innovative activities fostering interdisciplinary research and teaching in energy. As a director and chairman of the UNIHEAT Project, I led an international UK-Russia applied research programme for energy efficiency in the Oil & Gas sector.

On the entreprise front, I co-founded and led the management team of Process Systems Enterprise Ltd. ( ), an early Imperial spinoff in process simulation software and services. As managing director and chairman I led it from formation to 61st, then 30th position in the Sunday Times TechTrack100 list of fastest growing unquoted companies. The company now employs >160 in worldwide offices and was acquired by Siemens in 2019. I co-founded a second Imperial spinoff based on my research, Hexxcell Ltd. (high-tech heat transfer software and services – ) of which I was CEO until March 2018 when I sold my interests to the rest of the team.  My experience includes negotiating Intellectual Property, technology licensing and commercial agreements. As Enterprise Champion in the Faculty of Engineering at Imperial, I advise on and promote technology transfer initiatives.

Advisory activities include the Advisory Board of ENSIACET (Institut National Politechnique Toulouse, France), participation in and chairing of various Peer Review and Evaluation panels (including for the Italian Ministry of Education, French Ministry of Industry, and the Excellence Programme of the German Ministry for Research). I am a member of the Scientific Committee of the Institut Mines Telecom in Paris (a consortium of 10 research establishments), and serve on various Panels at the EU European Research Council (ERC) and as Strategic Advisor to Jiangsu Industrial Technology Research Institute, Nanjing (China). I chair as President the Evaluation Board of the Politecnico di Torino (Italy) that oversees all aspects of the university other than financial audit.

Awards include a “Queen’s Award for Excellence” (with CPSE) and a “Queen’s Award for Enterprise“ (with Process Systems Enterprise Ltd.), a Rector's Award for Excellence in Leadership and Management, and the Institution of Chemical Engineers Industry Award for Innovation and Excellence (Education and Training). The UNIHEAT Project was shortlisted in the “Research Project of the Year” category for the 2015 IChemE Global Awards.

I am the recipient of the McRobert Award, the top innovation prize of the Royal Academy of Engineering for profitable innovation, and the President’s Award and Medal for Outstanding Research, Imperial’s highest research award. In 2003 I was made by Presidential Decree a Cavaliere of the Order of Merit of the Italian Republic, the foremost National Order in Italy.

Selected Publications

Journal Articles

Gangar N, Macchietto S, Markides C, 2020, Recovery and utilization of low-grade waste heat in the oil-refining industry using heat engines and heat pumps: an international technoeconomic comparison, Energies, Vol:13, ISSN:1996-1073, Pages:2560-2560

Lozano Santamaria F, Macchietto S, 2020, Online integration of optimal cleaning scheduling and control of heat exchanger networks under fouling, Industrial & Engineering Chemistry Research, Vol:59, ISSN:0888-5885, Pages:2471-2490

Cameron IT, Engell S, Georgakis C, et al., 2019, Education in Process Systems Engineering: Why it matters more than ever and how it can be structured, Computers & Chemical Engineering, Vol:126, ISSN:0098-1354, Pages:102-112

Santamaria FL, Macchietto S, 2019, Integration of optimal cleaning scheduling and control of heat exchanger networks under fouling: MPCC solution, Computers & Chemical Engineering, Vol:126, ISSN:0098-1354, Pages:128-146

Vianello C, Mocellin P, Macchietto S, et al., 2016, Risk assessment in a hypothetical network pipeline in UK transporting carbon dioxide, Journal of Loss Prevention in the Process Industries, Vol:44, ISSN:0950-4230, Pages:515-527

Ho WS, Macchietto S, Lim JS, et al., 2016, Optimal scheduling of energy storage for renewable energy distributed energy generation system, Renewable & Sustainable Energy Reviews, Vol:58, ISSN:1364-0321, Pages:1100-1107

Diaz Bejarano E, Coletti F, Macchietto S, 2015, A new dynamic model of crude oil fouling deposits and its application to the simulation of fouling‐cleaning cycles, AICHE Journal, Vol:62, ISSN:0001-1541, Pages:90-107

Macchietto S, Coletti F, 2015, Innovation: Better together, TCE, ISSN:0302-0797, Pages:24-27

Coletti F, Macchietto S, 2011, A Dynamic, Distributed Model of Shell-and-Tube Heat Exchangers Undergoing Crude Oil Fouling, Industrial & Engineering Chemistry Research, Vol:50, ISSN:0888-5885, Pages:4515-4533

Coletti F, Macchietto S, 2011, Refinery Pre-Heat Train Network Simulation Undergoing Fouling: Assessment of Energy Efficiency and Carbon Emissions, Heat Transfer Engineering, Vol:32, ISSN:0145-7632, Pages:228-236

Galvanin F, Barolo M, Macchietto S, et al., 2009, Optimal Design of Clinical Tests for the Identification of Physiological Models of Type 1 Diabetes Mellitus, Industrial & Engineering Chemistry Research, Vol:48, ISSN:0888-5885, Pages:1989-2002

Franceschini G, Macchietto S, 2008, Novel anticorrelation criteria for model-based experiment design: Theory and formulations, AICHE Journal, Vol:54, ISSN:0001-1541, Pages:1009-1024


Bailey T, Liu P, Macchietto S, Optimisation of energy and water supply systems for the Dubai Waterfront, 9th International Conference on Foundations of Computer-Aided Process Design, Elsevier, Pages:107-112, ISSN:1570-7946

Macchietto S, Engineering success: What does it take to get PSE technologies used?, 29th European Symposium on Computer Aided Process Engineering, Elsevier, Pages:85-90, ISSN:1570-7946

Sharma A, Macchietto S, A computational study on fouling and cleaning operations in milk pasteurisation using a moving boundary model, 29th European Symposium on Computer Aided Process Engineering, elsevier

Veys A, Acha V, Macchietto S, A financial accounting based model of carbon footprinting: Built environment example, 29th European Symposium on Computer Aided Process Engineering, Elsevier, Pages:1663-1668, ISSN:1570-7946

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