Sarah Marzi is an Edmond and Lily Safra Research Fellow and UK DRI Emerging Leader at Imperial College's Dementia Research Institute. She is interested in epigenetic regulation in neurodegenerative disease, focussing specifically on the molecular drivers of Alzheimer's and Parkinson's disease. The Marzi lab uses a combination of wet lab and computational genomics approaches to understand the regulatory consequences of environmental and genetic risk factors of neurodegenerative disease. Dr Marzi leads the Experimental Models Working Group of the DEMON network.
Dr Marzi graduated in mathematics and psychology from the University of Freiburg, Germany, before undertaking a PhD at King's College London with Jonathan Mill. Her work looked at epigenetic signatures in human brain associated with ageing and neurodegeneration, as well as DNA modifications associated with early-life stress and victimisation. She identified widespread differences in histone acetylation in Alzheimer's disease compared to neuropathology-free brain, linking these epigenetic marks with genetic risk burden and gene expression signatures.
Her postdoctoral work with Vardhman Rakyan at Queen Mary University of London focussed on gene-environment interactions following developmental nutritional stress. Specifically, she worked on the assembly, genetic and epigenetic characterisation of ribosomal DNA in human and mouse, and investigated the role of methylomic correlates of paternal obesity in influencing offspring health.
Dr Di Hu, postdoctoral researcher
Maria Tsalenchuk, PhD student
Kitty Murphy, PhD student
Janis Transfeld, PhD student (2nd supervisor)
Leyla Abbasova, bioinformatics research assistant
A Cellular Malfunction: how cells lose control of their genes in Alzheimer’s disease - talk at the Making It Brain neuroscience research & careers webinar (15/09/2021)
The challenges of reproducibility - talk presented as part of a reproducibility workshop organised by the DEMON network, UK DRI and the UK Reproducibility Network (27/07/2021)
My path into neuroepigenomics - blog post for the DEMON network (01/07/2021)
The Genomics Lab - genomics-themed podcast (30/06/2021)
Epigenetic regulation in neurodegenerative disease - invited talk at the QMUL epigenetics webinar series (09/03/2021)
Careers in Dementia Research - Technology, Data and Innovation Researchers - careers panel for the Dementia Research Careers Festival and National Careers (03/03/2021)
A conversation with Dr Sarah Marzi, UK DRI at Imperial - interview on neurodegenerative disease epigenetics and science in lockdown (14/05/2020).
Dysregulation of histone acetylation in Alzheimer's disease - invited talk given at the PGC Pathways to Therapeutics conference (30/04/2020)
Rising research stars bolster Imperial’s dementia research mission - article introducing the new Safra fellows at Imperial College London (04/02/2020)
Murphy KB, Nott A, Marzi SJ, 2021, CHAS, a deconvolution tool, infers cell type-specific signatures in bulk brain histone acetylation studies of brain disorders
et al., 2021, Genetic variation at mouse and human ribosomal DNA influences associated epigenetic states
et al., 2021, Chd8 regulates X chromosome inactivation in mouse through fine-tuning control of Xist expression., Communications Biology, Vol:4, ISSN:2399-3642, Pages:1-13
et al., 2021, The histone modification H3K4me3 is altered at the ANK1 locus in Alzheimer's disease brain, Future Science Oa, Vol:7, ISSN:2056-5623, Pages:1-13