Imperial College London
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DrSarahMarzi

Faculty of Medicine, Department of Brain Sciences

Honorary Senior Lecturer
 
 
 
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Contact

 

s.marzi

 
 
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Location

 

Burlington DanesHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Marzi:2018:10.1038/s41593-018-0253-7,
author = {Marzi, SJ and Leung, SK and Ribarska, T and Hannon, E and Smith, AR and Pishva, E and Poschmann, J and Moore, K and Troakes, C and Al-Sarraj, S and Beck, S and Newman, S and Lunnon, K and Schalkwyk, LC and Mill, J},
doi = {10.1038/s41593-018-0253-7},
journal = {Nature Neuroscience},
pages = {1618--1627},
title = {A histone acetylome-wide association study of Alzheimer's disease identifies disease-associated H3K27ac differences in the entorhinal cortex},
url = {http://dx.doi.org/10.1038/s41593-018-0253-7},
volume = {21},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - We quantified genome-wide patterns of lysine H3K27 acetylation (H3K27ac) in entorhinal cortex samples from Alzheimer’s disease (AD) cases and matched controls using chromatin immunoprecipitation and highly parallel sequencing. We observed widespread acetylomic variation associated with AD neuropathology, identifying 4,162 differential peaks (false discovery rate < 0.05) between AD cases and controls. Differentially acetylated peaks were enriched in disease-related biological pathways and included regions annotated to genes involved in the progression of amyloid-β and tau pathology (for example, APP, PSEN1, PSEN2, and MAPT), as well as regions containing variants associated with sporadic late-onset AD. Partitioned heritability analysis highlighted a highly significant enrichment of AD risk variants in entorhinal cortex H3K27ac peak regions. AD-associated variable H3K27ac was associated with transcriptional variation at proximal genes including CR1, GPR22, KMO, PIM3, PSEN1, and RGCC. In addition to identifying molecular pathways associated with AD neuropathology, we present a framework for genome-wide studies of histone modifications in complex disease.
AU  - Marzi,SJ
AU  - Leung,SK
AU  - Ribarska,T
AU  - Hannon,E
AU  - Smith,AR
AU  - Pishva,E
AU  - Poschmann,J
AU  - Moore,K
AU  - Troakes,C
AU  - Al-Sarraj,S
AU  - Beck,S
AU  - Newman,S
AU  - Lunnon,K
AU  - Schalkwyk,LC
AU  - Mill,J
DO  - 10.1038/s41593-018-0253-7
EP  - 1627
PY  - 2018///
SN  - 1097-6256
SP  - 1618
TI  - A histone acetylome-wide association study of Alzheimer's disease identifies disease-associated H3K27ac differences in the entorhinal cortex
T2  - Nature Neuroscience
UR  - http://dx.doi.org/10.1038/s41593-018-0253-7
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000448319500016&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://www.nature.com/articles/s41593-018-0253-7
UR  - http://hdl.handle.net/10044/1/77074
VL  - 21
ER  -
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