Imperial College London
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DrSarahMarzi

Faculty of Medicine, Department of Brain Sciences

Honorary Senior Lecturer
 
 
 
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Contact

 

s.marzi

 
 
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Location

 

Burlington DanesHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Cerase:2021:10.1038/s42003-021-01945-1,
author = {Cerase, A and Young, AN and Ruiz, NB and Buness, A and Sant, GM and Arnold, M and Di, Giacomo M and Ascolani, M and Kumar, M and Hierholzer, A and Trigiante, G and Marzi, SJ and Avner, P},
doi = {10.1038/s42003-021-01945-1},
journal = {Communications Biology},
pages = {1--13},
title = {Chd8 regulates X chromosome inactivation in mouse through fine-tuning control of Xist expression.},
url = {http://dx.doi.org/10.1038/s42003-021-01945-1},
volume = {4},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Female mammals achieve dosage compensation by inactivating one of their two X chromosomes during development, a process entirely dependent on Xist, an X-linked long non-coding RNA (lncRNA). At the onset of X chromosome inactivation (XCI), Xist is up-regulated and spreads along the future inactive X chromosome. Contextually, it recruits repressive histone and DNA modifiers that transcriptionally silence the X chromosome. Xist regulation is tightly coupled to differentiation and its expression is under the control of both pluripotency and epigenetic factors. Recent evidence has suggested that chromatin remodelers accumulate at the X Inactivation Center (XIC) and here we demonstrate a new role for Chd8 in Xist regulation in differentiating ES cells, linked to its control and prevention of spurious transcription factor interactions occurring within Xist regulatory regions. Our findings have a broader relevance, in the context of complex, developmentally-regulated gene expression.
AU  - Cerase,A
AU  - Young,AN
AU  - Ruiz,NB
AU  - Buness,A
AU  - Sant,GM
AU  - Arnold,M
AU  - Di,Giacomo M
AU  - Ascolani,M
AU  - Kumar,M
AU  - Hierholzer,A
AU  - Trigiante,G
AU  - Marzi,SJ
AU  - Avner,P
DO  - 10.1038/s42003-021-01945-1
EP  - 13
PY  - 2021///
SN  - 2399-3642
SP  - 1
TI  - Chd8 regulates X chromosome inactivation in mouse through fine-tuning control of Xist expression.
T2  - Communications Biology
UR  - http://dx.doi.org/10.1038/s42003-021-01945-1
UR  - https://www.ncbi.nlm.nih.gov/pubmed/33859315
UR  - https://www.nature.com/articles/s42003-021-01945-1
UR  - http://hdl.handle.net/10044/1/88248
VL  - 4
ER  -
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