Imperial College London
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Dr Steven J. Millership

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Research Fellow
 
 
 
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Contact

 

+44 (0)20 7594 3110s.millership Website

 
 
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Location

 

323ICTEM buildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Millership:2013:10.4161/adip.25162,
author = {Millership, S and Ninkina, N and Rochford, JJ and Buchman, VL},
doi = {10.4161/adip.25162},
journal = {Adipocyte},
pages = {276--280},
title = {γ-synuclein is a novel player in the control of body lipid metabolism.},
url = {http://dx.doi.org/10.4161/adip.25162},
volume = {2},
year = {2013}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Synucleins are a family of homologous, predominantly neuronal proteins known for their involvement in synaptic transmission and neurodegeneration. γ-synuclein is predominantly localized in axons and presynaptic terminals of selected populations of peripheral and central neurons but is also highly expressed in human white adipose tissue (WAT) and increased in obesity. We have recently shown that γ-synuclein is nutritionally regulated in murine adipocytes while its loss protects mice from high fat diet (HFD)-induced obesity and associated metabolic complications. This protection was coupled with increased adipocyte lipolysis, lipid oxidation, and energy expenditure in HFD-fed γ-synuclein-null mutant compared with wild-type mice. Cellular studies suggest that relocalization of ATGL to the lipid droplet in γ-synuclein-deficient adipocytes may contribute to increased lipolysis in these cells. Loss of γ-synuclein in adipocytes also attenuates the assembly of SNARE complexes, an important component of lipid droplet fusion machinery, possibly due to reduced chaperoning of SNAP-23 to the assembling SNARE complex by γ-synuclein. Together our data suggests that not only is γ-synuclein a novel regulator of lipid handling in adipocytes but also that the deficiency of this protein has a significant effect on whole body energy expenditure.
AU  - Millership,S
AU  - Ninkina,N
AU  - Rochford,JJ
AU  - Buchman,VL
DO  - 10.4161/adip.25162
EP  - 280
PY  - 2013///
SN  - 2162-3945
SP  - 276
TI  - γ-synuclein is a novel player in the control of body lipid metabolism.
T2  - Adipocyte
UR  - http://dx.doi.org/10.4161/adip.25162
UR  - https://www.ncbi.nlm.nih.gov/pubmed/24052906
VL  - 2
ER  -
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