Imperial College London
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Dr Steven J. Millership

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Research Fellow
 
 
 
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Contact

 

+44 (0)20 7594 3110s.millership Website

 
 
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Location

 

323ICTEM buildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@inbook{Yu:2022:10.1016/B978-0-12-821785-6.00011-6,
author = {Yu, V and Stamoulis, Z and Chen, K and Jiang, J and He, Z and Rutter, GA and Millership, SJ},
booktitle = {Perinatal and Developmental Epigenetics: Volume 32 in Translational Epigenetics},
doi = {10.1016/B978-0-12-821785-6.00011-6},
pages = {115--136},
title = {Genomic imprinting and developmental physiology: intrauterine growth and postnatal period},
url = {http://dx.doi.org/10.1016/B978-0-12-821785-6.00011-6},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - CHAP
AB  - In therian mammals, genomic imprinting, typically via methylation of either the paternal or maternal allele, results in a monoallelic and parent-of-origin expression pattern of a subset of genes. Careful maintenance of the expression of these “imprinted” genes is crucial to mammalian development, with misexpression in humans or model organisms evidenced in a series of prenatal, neonatal, and postnatal growth and developmental phenotypes that impact adult metabolic health. Imprinted genes exert their effects in utero via both placental and embryonic tissues, with their dysregulation leading to fetal growth defects and abnormal control of placental resources. In the neonatal and postnatal period, they govern the feeding, thermoregulation, and social behaviors in both the offspring and the mother. Furthermore, metabolic syndrome in adulthood is a consequence of gene-environment interactions via altered imprinted gene expression in the postnatal period, demonstrating the importance of tightly controlled growth and development in early life.
AU  - Yu,V
AU  - Stamoulis,Z
AU  - Chen,K
AU  - Jiang,J
AU  - He,Z
AU  - Rutter,GA
AU  - Millership,SJ
DO  - 10.1016/B978-0-12-821785-6.00011-6
EP  - 136
PY  - 2022///
SN  - 9780128217863
SP  - 115
TI  - Genomic imprinting and developmental physiology: intrauterine growth and postnatal period
T1  - Perinatal and Developmental Epigenetics: Volume 32 in Translational Epigenetics
UR  - http://dx.doi.org/10.1016/B978-0-12-821785-6.00011-6
ER  -
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