WELLCOME TRUST CAREER DEVELOPMENT FELLOW
HONORARY CONSULTANT IN METABOLIC MEDICINE
Dr Shivani Misra is a Wellcome Trust Career Development Fellow, Senior Clinical Lecturer within Imperial College London & Honorary Diabetes Consultant.
Dr Misra has two main areas of interest and expertise:
1) She leads a portfolio of studies that investigate the genetics, epidemiology, classification and treatment of early-onset type 2 diabetes, defined as a diagnosis of type 2 diabetes in childhood or early-adulthood (<40 years).
2) She leads a number of studies that advance understanding of precision medicine in diabetes focussing on under-represented populations, ethnic diversity and in a broader sense, global considerations around implemtation.
In 2023 she was awarded the Precision Medicine in Diabetes Award from the European Association for the Study of Diabetes & Novo Nordisk Foundation.
Dr Misra was awarded a Future Leaders Award from the European Federation for the Study of Diabetes (2017) and in 2021 was awarded a QiC award from NHS England for contributions to diabetes research / services
Dr Misra serves as Co-Chair for the NIDDK clinical working group on type 2 diabetes heterogeneity and served as co-chair of the joint ADA/EASD precision medicine initiative on type 2 diabetes diagnostics from 2021-2023
Selected active studies:
A person diagnosed with type 2 diabetes at young age has a higher risk for the development of diabetes complications than later-onset type 2 diabetes and, unfortunately, large studies show that they do not live as long as people who are diagnosed later in life. The factors that drive these concerning outcomes, remain unclear. Dr Misra and her team are investigating this clinical problem in a portfolio of studies:
1) Wellcome Trust funded study investigating the genetics and epidemiology of early-onset type 2 diabetes in south Asian individuals
2) NIHR funded collaborative study (M3 programme) developing an holistic multi-modal intervention for adults with early-onset type 2 diabetes, tested through qualitative patient-reported outcomes and quantitative microvascular and glucose outcomes in an RCT.
3) Diabetes UK funded study that will investigate the use of prediction models to segregate early-onset type 2 diabetes from other forms of diabetes including monogenic and type 1 diabetes, in south Asian and African-Caribbean individuals with early-onset diabetes.
4) Diabetes UK funded studentship (collaborative with Professor Guy Rutter) to investigate the effect of rare MODY mutations on iPSC-derived pancreatic beat-cells from human fibroblasts (DiPS study).
"Using genetic, epidemiological and interventional studies, we are working to discover the best way to detect, classify and treat people with early-onset type 2 diabetes from all ethnic backgrounds" Dr Shivani Misra
During her Doctoral project, Dr Misra set up the MY DIABETES study, which has recruited almost 1800 individuals over 40 hospitals around England. The MY DIABETES study aimed to phenotype young-onset diabetes in south Asian and African-Caribbean ethnicities in the UK. Her core research interest focuses on stratifying young-onset diabetes using biomarkers and genetics to improve treatment and identification of young-onset diabetes types.
Prior to her Doctoral work, Shivani was an NIHR Academic Clinical Fellow in metabolic medicine & chemical pathology and completed a PhD in the Section of Diabetes, Endocrinology & Metabolism, funded by a Sutherland-Earl Clinical Research Fellowship from the Diabetes Research and Wellness Foundation.
She has trained in diabetes, clinical biochemistry and laboratory medicine and is a Fellow of the Royal College of Pathologists and Member of the Royal College of Physicians.
2. Trustee of the Diabetes Research & Wellness Foundation, diabetes charity
3. Conference organising committee member, Diabetes UK 2020-2023
4. Member of the young-onset type 2 diabetes NHS Digital National Diabetes audit working group 2021
5. Member of the NDISA (NADIA - Harms) strategy group, NHS Digital, National Diabetes Audit
et al., 2024, Optimized protocol for generating functional pancreatic insulin-secreting cells from human pluripotent stem cells, Journal of Visualized Experiments, ISSN:1940-087X
et al., 2023, Diabetes and Multiple Long-term Conditions: A Review of Our Current Global Health Challenge., Diabetes Care, Vol:46, Pages:2092-2101
et al., 2023, The case for precision medicine in the prevention, diagnosis, and treatment of cardiometabolic diseases in low-income and middle-income countries., Lancet Diabetes Endocrinol, Vol:11, Pages:836-847
et al., 2023, Precision subclassification of type 2 diabetes: a systematic review., Commun Med (lond), Vol:3
et al., 2023, The use of precision diagnostics for monogenic diabetes: a systematic review and expert opinion., Commun Med (lond), Vol:3