Imperial College London
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Dr Shivani Misra

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Clinical Senior Lecturer in Diabetes and Endocrinology
 
 
 
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Contact

 

s.misra

 
 
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Location

 

Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Walkey:2017:10.1136/bmjopen-2016-013956,
author = {Walkey, HC and Kaur, A and Bravis, V and Godsland, IF and Misra, S and Williams, AJK and Bingley, PJ and Dunger, DB and Oliver, N and Johnston, DG},
doi = {10.1136/bmjopen-2016-013956},
journal = {BMJ Open},
title = {Rationale and protocol for the After Diabetes Diagnosis REsearch Support System (ADDRESS): an incident and high risk type 1 diabetes UK cohort study.},
url = {http://dx.doi.org/10.1136/bmjopen-2016-013956},
volume = {7},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - INTRODUCTION: Type 1 diabetes is heterogeneous in its presentation and progression. Variations in clinical presentation between children and adults, and with ethnic group warrant further study in the UK to improve understanding of this heterogeneity. Early interventions to limit beta cell damage in type 1 diabetes are undergoing evaluation, but recruitment is challenging. The protocol presented describes recruitment of people with clinician-assigned, new-onset type 1 diabetes to understand the variation in their manner of clinical presentation, to facilitate recruitment into intervention studies and to create an open-access resource of data and biological samples for future type 1 diabetes research. METHODS AND ANALYSIS: Using the National Institute for Health Research Clinical Research Network, patients >5 years of age diagnosed clinically with type 1 diabetes (and their siblings) are recruited within 6 months of diagnosis. Participants agree to have their clinical, laboratory and demographic data stored on a secure database, for their clinical progress to be monitored using information held by NHS Digital, and to be contacted about additional research, in particular immunotherapy and other interventions. An optional blood sample is taken for islet autoantibody measurement and storage of blood and DNA for future analyses. Data will be analysed statistically to describe the presentation of incident type 1 diabetes in a contemporary UK population. ETHICS AND DISSEMINATION: Ethical approval was obtained from the independent NHS Research Ethics Service. Results will be presented at national and international meetings and submitted for publication to peer-reviewed journals.
AU  - Walkey,HC
AU  - Kaur,A
AU  - Bravis,V
AU  - Godsland,IF
AU  - Misra,S
AU  - Williams,AJK
AU  - Bingley,PJ
AU  - Dunger,DB
AU  - Oliver,N
AU  - Johnston,DG
DO  - 10.1136/bmjopen-2016-013956
PY  - 2017///
SN  - 2044-6055
TI  - Rationale and protocol for the After Diabetes Diagnosis REsearch Support System (ADDRESS): an incident and high risk type 1 diabetes UK cohort study.
T2  - BMJ Open
UR  - http://dx.doi.org/10.1136/bmjopen-2016-013956
UR  - https://www.ncbi.nlm.nih.gov/pubmed/28706084
UR  - http://hdl.handle.net/10044/1/51670
VL  - 7
ER  -
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