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@article{Miles:2017:10.1038/nature24995,
author = {Miles, A and Harding, NJ and Botta, G and Clarkson, CS and Antao, T and Kozak, K and Schrider, DR and Kern, AD and Redmond, S and Sharakhov, I and Pearson, RD and Bergey, C and Fontaine, MC and Donnelly, MJ and Lawniczak, MKN and Kwiatkowski, DP and Ayala, D and Besensky, NJ and Burt, A and Caputo, B and della, Torre A and Fontaine, MC and Godfrey, HCJ and Hahn, MW and Midega, J and Neafsey, DE and O'Loughlin, S and Pinto, J and Riehle, MM and Vernick, KD and Weetman, D and Wilding, CS and White, BJ and Troco, AD and Diabate, A and Costantini, C and Rohatgi, KR and Besansky, NJ and Elissa, N and Coulibaly, B and Dinis, J and Midegal, J and Mbogo, C and Bejon, P and Mawejje, HD and Stalker, J and Rockett, K and Drury, E and Mead, D and Jeffreys, A and Hubbard, C and Rowlands, K and Isaacs, AT and Jyothi, D and Malangone, C and Vauterin, P and Jeffery, B and Wright, I and Hart, L and Kluczyriski, K and Cornelius, V and MacInnisn, B and Henrichs, C and Giacomantonio, R},
doi = {10.1038/nature24995},
journal = {Nature},
pages = {96--100},
title = {Genetic diversity of the African malaria vector Anopheles gambiae},
url = {http://dx.doi.org/10.1038/nature24995},
volume = {552},
year = {2017}
}

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TY  - JOUR
AB  - The sustainability of malaria control in Africa is threatened by the rise of insecticide resistance in Anopheles mosquitoes, which transmit the disease1. To gain a deeper understanding of how mosquito populations are evolving, here we sequenced the genomes of 765 specimens of Anopheles gambiae and Anopheles coluzzii sampled from 15 locations across Africa, and identified over 50 million single nucleotide polymorphisms within the accessible genome. These data revealed complex population structure and patterns of gene flow, with evidence of ancient expansions, recent bottlenecks, and local variation in effective population size. Strong signals of recent selection were observed in insecticide-resistance genes, with several sweeps spreading over large geographical distances and between species. The design of new tools for mosquito control using gene-drive systems will need to take account of high levels of genetic diversity in natural mosquito populations.
AU  - Miles,A
AU  - Harding,NJ
AU  - Botta,G
AU  - Clarkson,CS
AU  - Antao,T
AU  - Kozak,K
AU  - Schrider,DR
AU  - Kern,AD
AU  - Redmond,S
AU  - Sharakhov,I
AU  - Pearson,RD
AU  - Bergey,C
AU  - Fontaine,MC
AU  - Donnelly,MJ
AU  - Lawniczak,MKN
AU  - Kwiatkowski,DP
AU  - Ayala,D
AU  - Besensky,NJ
AU  - Burt,A
AU  - Caputo,B
AU  - della,Torre A
AU  - Fontaine,MC
AU  - Godfrey,HCJ
AU  - Hahn,MW
AU  - Midega,J
AU  - Neafsey,DE
AU  - O'Loughlin,S
AU  - Pinto,J
AU  - Riehle,MM
AU  - Vernick,KD
AU  - Weetman,D
AU  - Wilding,CS
AU  - White,BJ
AU  - Troco,AD
AU  - Diabate,A
AU  - Costantini,C
AU  - Rohatgi,KR
AU  - Besansky,NJ
AU  - Elissa,N
AU  - Coulibaly,B
AU  - Dinis,J
AU  - Midegal,J
AU  - Mbogo,C
AU  - Bejon,P
AU  - Mawejje,HD
AU  - Stalker,J
AU  - Rockett,K
AU  - Drury,E
AU  - Mead,D
AU  - Jeffreys,A
AU  - Hubbard,C
AU  - Rowlands,K
AU  - Isaacs,AT
AU  - Jyothi,D
AU  - Malangone,C
AU  - Vauterin,P
AU  - Jeffery,B
AU  - Wright,I
AU  - Hart,L
AU  - Kluczyriski,K
AU  - Cornelius,V
AU  - MacInnisn,B
AU  - Henrichs,C
AU  - Giacomantonio,R
DO  - 10.1038/nature24995
EP  - 100
PY  - 2017///
SN  - 0028-0836
SP  - 96
TI  - Genetic diversity of the African malaria vector Anopheles gambiae
T2  - Nature
UR  - http://dx.doi.org/10.1038/nature24995
UR  - http://hdl.handle.net/10044/1/84173
VL  - 552
ER  -

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