Imperial College London
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DrSarahOnida

Faculty of Medicine, Department of Surgery & Cancer

Honorary Clinical Senior Lecturer
 
 
 
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Contact

 

+44 (0)20 3311 7317s.onida Website

 
 
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Location

 

4N 12North WingCharing Cross Campus

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Summary

 

Publications

Citation

BibTex format

@article{Gwilym:2021:10.1016/j.ejvs.2020.11.053,
author = {Gwilym, B and Dovell, G and Dattani, N and Ambler, G and Shalhoub, J and Forsythe, R and Benson, R and Nandhra, S and Preece, R and Onida, S and Hitchman, L and Coughlin, P and Saratzis, A and Bosanquet, D},
doi = {10.1016/j.ejvs.2020.11.053},
journal = {European Journal of Vascular and Endovascular Surgery},
pages = {636--646},
title = {Systematic review and meta-analysis of wound adjuncts for the prevention of groin wound surgical site infection in arterial surgery},
url = {http://dx.doi.org/10.1016/j.ejvs.2020.11.053},
volume = {61},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Review methodsThis review was undertaken according to established international reporting guidelines and was registered prospectively with the International prospective register of systematic reviews (CRD42020185170). The MEDLINE, EMBASE, and CENTRAL databases were searched using pre-defined search terms without date restriction. Randomised controlled trials (RCTs) and observational studies recruiting patients with non-infected groin incisions for arterial exposure were included; SSI rates and other outcomes were captured. Interventions reported in two or more studies were subjected to meta-analysis.ResultsThe search identified 1 532 articles. Seventeen RCTs and seven observational studies, reporting on 3 747 patients undergoing 4 130 groin incisions were included. A total of seven interventions and nine outcomes were reported upon. Prophylactic closed incision negative pressure wound therapy (ciNPWT) reduced groin SSIs compared with standard dressings (odds ratio [OR] 0.34, 95% CI 0.23 – 0.51; p < .001, GRADE strength of evidence: moderate). Local antibiotics did not reduce groin SSIs (OR 0.60 95% CI 0.30 – 1.21 p = .15, GRADE strength: low). Subcuticular sutures (vs. transdermal sutures or clips) reduced groin SSI rates (OR 0.33, 95% CI 0.17 – 0.65, p = .001, GRADE strength: low). Wound drains, platelet rich plasma, fibrin glue, and silver alginate dressings did not show any significant effect on SSI rates.ConclusionThere is evidence that ciNPWT and subcuticular sutures reduce groin SSI in patients undergoing arterial vascular interventions involving a groin incision. Local antibiotics did not reduce groin wound SSI, although the strength of this evidence is lower. No other interventions demonstrated a significant effect.
AU  - Gwilym,B
AU  - Dovell,G
AU  - Dattani,N
AU  - Ambler,G
AU  - Shalhoub,J
AU  - Forsythe,R
AU  - Benson,R
AU  - Nandhra,S
AU  - Preece,R
AU  - Onida,S
AU  - Hitchman,L
AU  - Coughlin,P
AU  - Saratzis,A
AU  - Bosanquet,D
DO  - 10.1016/j.ejvs.2020.11.053
EP  - 646
PY  - 2021///
SN  - 1078-5884
SP  - 636
TI  - Systematic review and meta-analysis of wound adjuncts for the prevention of groin wound surgical site infection in arterial surgery
T2  - European Journal of Vascular and Endovascular Surgery
UR  - http://dx.doi.org/10.1016/j.ejvs.2020.11.053
UR  - https://www.sciencedirect.com/science/article/pii/S1078588420310777?via%3Dihub
UR  - http://hdl.handle.net/10044/1/85754
VL  - 61
ER  -
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