Imperial College London

DrSimonPadley

Faculty of MedicineNational Heart & Lung Institute

Professor of Practice (Diagnostic & Interventional Radiology
 
 
 
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Contact

 

+44 (0)20 7351 8381s.padley CV

 
 
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Location

 

CT ReportingSydney StreetRoyal Brompton Campus

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Summary

 

Publications

Publication Type
Year
to

233 results found

Mirsadraee S, Gorog DA, Mahon CF, Rawal B, Semple TR, Nicol ED, Arachchillage DRJ, Devaraj A, Price S, Desai SR, Ridge CA, Singh S, Padley SPGet al., 2021, Prevalence of Thrombotic Complications in ICU-Treated Patients With Coronavirus Disease 2019 Detected With Systematic CT Scanning, CRITICAL CARE MEDICINE, Vol: 49, Pages: 804-815, ISSN: 0090-3493

Journal article

Barnett J, Pulzato I, Javed M, Lee YJ, Choraria A, Kemp S, Rice A, Jordan S, Shah PL, Nicholson AG, Padley S, Devaraj Aet al., 2021, Radiological-pathological correlation of negative CT biopsy results enables high negative predictive value for thoracic malignancy, CLINICAL RADIOLOGY, Vol: 76, ISSN: 0009-9260

Journal article

Neville JJ, Chacon CS, Jordan S, Roberton B, Semple T, Padley S, Clarke SAet al., 2021, Use of lymphangiography in neonates prior to thoracic duct ligation, JOURNAL OF PEDIATRIC SURGERY CASE REPORTS, Vol: 64, ISSN: 2213-5766

Journal article

Castro-Verdes M, Gkouma A, Wort J, Ridge C, Mirsadraee S, Padley S, Sheikh A, Singh Set al., 2020, Corona Virus Disease 2019 in situ arterial and venous thrombosis in critically ill patients: a case series, European Heart Journal: Case Reports, Vol: 4, Pages: 1-7, ISSN: 2514-2119

BackgroundCorona Virus Disease 2019 (COVID-19) pneumonitis associated with severe respiratory failure carries a high mortality. Coagulopathy has emerged as a significant contributor to thrombotic complications.Case summaryWe describe two cases of severe COVID-19 pneumonitis refractory to conventional mechanical ventilation and proning position, transferred to our specialist centre for cardiorespiratory failure. Cross-sectional imaging demonstrated concurrent venous and aortic thrombosis with end-organ ischaemic changes. One patient received thrombolysis with a partial response. This could not be offered to the other patient due to a recent haemorrhagic event. Both patients died of multi-organ failure in the hospital.DiscussionConcurrent aortic and venous thromboses are rare. This finding in COVID-19 cases, who were both critically ill patients, likely reflects the strongly thrombogenic nature of this illness which ultimately contributed to poor outcomes. The absence of deep vein thrombosis or a potential systemic source of embolism suggests in situ thrombosis. Further, the management of anticoagulation and thrombolysis is challenging in patients where an attendant bleeding risk exists.

Journal article

Woodhull S, Bush A, Tang AL, Padley Set al., 2020, Massive paediatric pulmonary haemorrhage in Dieulafoy's disease: Roles of CT angiography, embolisation and bronchoscopy., Paediatr Respir Rev, Vol: 36, Pages: 100-105

Acute, major pulmonary haemorrhage in children, is rare, may be life-threatening and at times presents atypically. Dieulafoy's disease of the bronchus presenting with recurrent or massive hemoptysis was first described in adults. Prior to reviewing the literature, we report an illustrative case of bronchial Dieulafoy's disease (BDD) in a child presenting unusually with massive apparent hematemesis. The source of bleeding is a bronchial artery that fails to taper as it terminates within the bronchial submucosa. A high index of suspicion is required to identify such lesions via radiological imaging and the role of bronchial artery embolisation is highlighted with video images of angiography included.

Journal article

Arachchillage DJ, Desai SR, Devaraj A, Ridge CA, Padley SPG, Patel BV, all authors of Pulmonary Angiopathy in Severe COVID-19 Physiologic, Imaging and Hematologic Observationset al., 2020, Reply to: Sanfilippo et al Caviedes et al., American Journal of Respiratory and Critical Care Medicine, Vol: 203, Pages: 261-263, ISSN: 1073-449X

Journal article

Fischer AJ, Nagarajan VD, Padley S, Ernst Set al., 2020, When a multipolar catheter misses an “arm”: A known complication experienced anew, HeartRhythm Case Reports, Vol: 6, Pages: 745-748

Journal article

Bartlett EC, Kemp S, Ridge CA, Desai SR, Mirsadraee S, Morjaria JB, Shah PL, Popat S, Nicholson AG, Rice AJ, Jordan S, Begum S, Mani A, Derbyshire J, Morris K, Chen M, Peacock C, Addis J, Martins M, Kaye SB, Padley SPG, Devaraj A, McDonald F, Robertus JL, Lim E, Barnett J, Finch J, Dalal P, Yousaf N, Jamali A, Ivashniova N, Phillips C, Newsom-Davies T, Lee R, Vaghani P, Whiteside S, Vaughan-Smith Set al., 2020, Baseline Results of the West London lung cancer screening pilot study - Impact of mobile scanners and dual risk model utilisation, LUNG CANCER, Vol: 148, Pages: 12-19, ISSN: 0169-5002

Journal article

Patel BV, Arachchillage DJ, Ridge CA, Bianchi P, Doyle JF, Garfield B, Ledot S, Morgan C, Passariello M, Price S, Singh S, Thakuria L, Trenfield S, Trimlett R, Weaver C, Wort SJ, Xu T, Padley SPG, Devaraj A, Desai SRet al., 2020, Pulmonary angiopathy in severe COVID-19: physiologic, imaging and hematologic observations, American Journal of Respiratory and Critical Care Medicine, Vol: 202, Pages: 690-699, ISSN: 1073-449X

Rationale: Clinical and epidemiologic data in coronavirus disease 2019 (Covid-19) have accrued rapidly since the outbreak but few address the underlying pathophysiology. Objectives: To ascertain the physiologic, hematologic and imaging basis of lung injury in severe Covid-19 pneumonia. Methods: Clinical, physiologic and laboratory data were collated. Radiologic (computed tomography pulmonary angiography [CTPA, n=39] and dual-energy CT [DECT, n=20]) studies were evaluated: observers quantified CT patterns (including the extent of abnormal lung and the presence/extent of dilated peripheral vessels) and perfusion defects on DECT. Coagulation status was assessed using thromboelastography (TEG). Measurements and Results: In 39 consecutive patients (M:F 32:7; mean age, 53±10 years [range 29-79 years]; black and ethnic minority, n=25 [64%]), there was a significant vascular perfusion abnormality and increased physiologic dead-space (dynamic compliance, 33.7±14.7 mls/cmH2O; Murray Lung Injury Score, 3.14±0.53; mean ventilatory ratios, 2.6±0.8) with evidence of hypercoagulability and fibrinolytic ‘shutdown’. The mean CT extent (±SD) of normally-aerated lung, ground-glass opacification and dense parenchymal opacification were 23.5±16.7%, 36.3±24.7% and 42.7±27.1%, respectively. Dilated peripheral vessels were present in 21/33 (63.6%) patients with at least two assessable lobes (including 10/21 [47.6%] with no evidence of acute pulmonary emboli). Perfusion defects on DECT (assessable in 18/20 [90%]), were present in all patients (wedge-shaped, n=3; mottled, n= 9; mixed pattern, n=6). Conclusions: Physiologic, hematologic and imaging data show not only the presence of a hypercoagulable phenotype in severe Covid-19 pneumonia but also markedly impaired pulmonary perfusion likely caused by pulmonary angiopathy and thrombosis.

Journal article

Bartlett EC, Kemp S, Derbyshire J, Morris K, Addis J, Ridge C, Mirsadraee S, Padley S, Desai SR, Devaraj Aet al., 2019, IMPLICATIONS AND OUTCOMES OF CLINICAL AND RADIOLOGICAL INCIDENTAL LUNG CANCER SCREENING FINDINGS FOR PRIMARY CARE - RESULTS FROM A PILOT SCREENING STUDY, Winter Meeting of the British-Thoracic-Society, Publisher: BMJ PUBLISHING GROUP, Pages: A129-A129, ISSN: 0040-6376

Conference paper

Bartlett E, Kemp S, Desai S, Mirsadraee S, Ridge C, Morjaria J, Shah P, Morris K, Derbyshire J, Chen M, Peacock C, Ivashniova N, Martins M, Addis J, Padley S, Devaraj Aet al., 2019, Uptake in Lung Cancer Screening - Does CT Location Matter? A Pilot Study Comparison of a Mobile and Hospital Based CT Scanner, Publisher: ELSEVIER SCIENCE INC, Pages: S289-S289, ISSN: 1556-0864

Conference paper

Devaraj A, Pulzato I, Kemp S, Ridge C, Padley S, Nicholson A, Arteta C, Novotny P, Pickup L, Declerck J, Kadir Tet al., 2019, What Is the Impact of Localised Data When Training Deep Neural Networks for Lung Cancer Prediction?, Publisher: ELSEVIER SCIENCE INC, Pages: S797-S797, ISSN: 1556-0864

Conference paper

Barnett J, Pulzato I, Burn T, Zafar S, Hine J, Bartlett E, Shah P, Nicholson A, Ridge C, Padley S, Molyneaux P, Kemp S, Devaraj Aet al., 2019, Very Rapid Growth of Small Pulmonary Nodules Predicts Benignity, Publisher: ELSEVIER SCIENCE INC, Pages: S528-S528, ISSN: 1556-0864

Conference paper

Spiro SG, Shah PL, Rintoul RC, George J, Janes S, Callister M, Novelli M, Shaw P, Kocjan G, Griffiths C, Falzon M, Booton R, Magee N, Peake M, Dhillon P, Sridharan K, Nicholson AG, Padley S, Taylor MN, Ahmed A, Allen J, Ngai Y, Chinyanganya N, Ashford-Turner V, Lewis S, Oukrif D, Rabbitts P, Counsell N, Hackshaw Aet al., 2019, Sequential screening for lung cancer in a high-risk group: randomised controlled trial, European Respiratory Journal, Vol: 54, ISSN: 0903-1936

BACKGROUND: Low-dose computed tomography (LDCT) screening detects early-stage lung cancer and reduces mortality. We proposed a sequential approach targeted to a high-risk group as a potentially efficient screening strategy. METHODS: LungSEARCH was a national multicentre randomised trial. Current/ex-smokers with mild/moderate chronic obstructive pulmonary disease (COPD) were allocated (1:1) to have 5 years surveillance or not. Screened participants provided annual sputum samples for cytology and cytometry, and if abnormal were offered annual LDCT and autofluorescence bronchoscopy (AFB). Those with normal sputum provided annual samples. The primary end-point was the percentage of lung cancers diagnosed at stage I/II (nonsmall cell) or limited disease (small cell). RESULTS: 1568 participants were randomised during 2007-2011 from 10 UK centres. 85.2% of those screened provided an adequate baseline sputum sample. There were 42 lung cancers among 785 screened individuals and 36 lung cancers among 783 controls. 54.8% (23 out of 42) of screened individuals versus 45.2% (14 out of 31) of controls with known staging were diagnosed with early-stage disease (one-sided p=0.24). Relative risk was 1.21 (95% CI 0.75-1.95) or 0.82 (95% CI 0.52-1.31) for early-stage or advanced cancers, respectively. Overall sensitivity for sputum (in those randomised to surveillance) was low (40.5%) with a cumulative false-positive rate (FPR) of 32.8%. 55% of cancers had normal sputum results throughout. Among sputum-positive individuals who had AFB, sensitivity was 45.5% and cumulative FPR was 39.5%; the corresponding measures for those who had LDCT were 100% and 16.1%, respectively. CONCLUSIONS: Our sequential strategy, using sputum cytology/cytometry to select high-risk individuals for AFB and LDCT, did not lead to a clear stage shift and did not improve the efficiency of lung cancer screening.

Journal article

Sathianandan S, Rawal B, Nashat H, Price L, Padley S, Dimopoulos K, Semple T, Wort Jet al., 2019, A retrospective review of computed tomography (CT) findings in Eisenmenger Syndrome and their prognostic implications, European-Respiratory-Society (ERS) International Congress, Publisher: EUROPEAN RESPIRATORY SOC JOURNALS LTD, ISSN: 0903-1936

Conference paper

Barnett J, Pulzato I, Wilson R, Padley S, Nicholson AG, Devaraj Aet al., 2019, Perinodular Vascularity Distinguishes Benign Intrapulmonary Lymph Nodes From Lung Cancer on Computed Tomography, JOURNAL OF THORACIC IMAGING, Vol: 34, Pages: 326-328, ISSN: 0883-5993

Journal article

Garner JL, Donovan J, Meireles I, Padley SPG, Cunningham D, Shah PLet al., 2019, A Golden Conundrum, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 200, Pages: 631-632, ISSN: 1073-449X

Journal article

Barnett J, Pulzato I, Padley S, Jordan S, Nicholson AG, Rice A, Choraria A, Javed M, Lee YJ, Kemp S, Shah P, Devaraj Aet al., 2019, Radiological-pathological correlation of negative CT biopsy results enables high negative predictive value for thoracic malignancy, Publisher: ELSEVIER IRELAND LTD, Pages: S16-S16, ISSN: 0169-5002

Conference paper

Wong PM, Padley SP, 2018, Cardiac computed tomography, Medicine (United Kingdom), Vol: 46, Pages: 474-479, ISSN: 1357-3039

Advances in computed tomography (CT) technology now allow definitive imaging of the coronary arteries. Non-enhanced CT is used to perform coronary artery calcium scoring, which is useful to stratify the risk of future coronary events but does not allow assessment of stenosis. Contrast-enhanced CT coronary angiography (CTCA) enables angiographic evaluation of both the coronary artery lumen and wall. The high negative predictive accuracy of CTCA makes it a useful test to rule out the presence of significant coronary stenoses, especially in patients with an intermediate pre-test likelihood of coronary artery disease. CTCA also has potential to aid the triage of patients with acute chest pain in the emergency department. CTCA can determine the approximate degree of stenosis as well as detect high-risk plaque characteristics. Coronary artery bypass grafts can be assessed reliably using CT. Intracoronary stent evaluation is possible because of advances in temporal resolution. Myocardial perfusion imaging using cardiac CT is the subject of current investigation.

Journal article

Dreisbach JG, Nicol ED, Roobottom CA, Padley S, Roditi Get al., 2018, Challenges in delivering computed tomography coronary angiography as the first-line test for stable chest pain, Heart, Vol: 104, Pages: 921-927, ISSN: 1355-6037

Objective The National Institute for Health and Care Excellence (NICE) clinical guidelines ‘chest pain of recent onset: assessment and diagnosis’ (update 2016) state CT coronary angiography (CTCA) should be offered as the first-line investigation for patients with stable chest pain. However, the current provision in the UK is unknown. We aimed to evaluate this and estimate the requirements for full implementation of the guidelines including geographical variation. Ancillary aims included surveying the number of CTCA-capable scanners and accredited practitioners in the UK.Methods The number of CTCA scans performed annually was surveyed across the National Health Service (NHS). The number of percutaneous coronary interventions performed for stable angina in the NHS in 2015 was applied to a model based on SCOT-HEART (CTCA in patients with suspected angina due to coronary heart disease: an open-label, parallel-group, multicentre trial) data to estimate the requirement for CTCA, for full guideline implementation. Details of CTCA-capable scanners were obtained from manufacturers and formally accredited practitioner details from professional societies.Results An estimated 42 340 CTCAs are currently performed annually in the UK. We estimate that 350 000 would be required to fully implement the guidelines. 304 CTCA-capable scanners and 198 accredited practitioners were identified. A marked geographical variation between health regions was observed.Conclusions This study provides insight into the scale of increase in the provision of CTCA required to fully implement the updated NICE guidelines. A small specialist workforce and limited number of CTCA-capable scanners may present challenges to service expansion.

Journal article

Allen CJ, Freeman T, Perera W, Padley SP, Hind Met al., 2018, Thoracic Park: cardiac MRI reveals massive thoracic varices as consequence of inferior vena cava ligation, EHJ Cardiovascular Imaging / European Heart Journal - Cardiovascular Imaging, Vol: 19, Pages: 359-360, ISSN: 2047-2412

Journal article

Padley SPG, Roditi G, Nicol ED, 2017, Chest pain of recent onset: assessment and diagnosis (CG95). A step change in the requirement for cardiovascular CT, CLINICAL RADIOLOGY, Vol: 72, Pages: 751-753, ISSN: 0009-9260

Journal article

Ismail TF, Cheasty E, King L, Naaseri S, Lazoura O, Gartland N, Padley S, Rubens MB, Castellano I, Nicol EDet al., 2017, High-pitch versus conventional cardiovascular CT in patients being assessed for transcatheter aortic valve implantation: A real-world appraisal, Open Heart, Vol: 4, ISSN: 2053-3624

Objective High-pitch protocols are increasingly used in cardiovascular CT assessment for transcatheter aortic valve implantation (TAVI), but the impact on diagnostic image quality is not known. Methods We reviewed 95 consecutive TAVI studies: 44 (46%) high-pitch and 51 (54%) standard-pitch. Single high-pitch scans were performed regardless of heart rate. For standard-pitch acquisitions, a separate CT-aortogram and CT-coronary angiogram were performed with prospective gating, unless heart rate was ≥70 beats/min, when retrospective gating was used. The aortic root and coronary arteries were assessed for artefact (significant artefact=1; artefact not limiting diagnosis=2; no artefact=3). Aortic scans were considered diagnostic if the score was > 1; the coronaries, if all three epicardial arteries scored > 1. Results There was no significant difference in diagnostic image quality for either the aorta (artefact-free high-pitch: 31 (73%) scans vs standard-pitch: 40 (79%), p=0.340) or the coronary tree as a whole (10 (23%) vs 15 (29%), p=0.493). However, proximal coronary arteries were less well visualised using high-pitch acquisitions (16 (36%) vs 30 (59%), p=0.04). The median (IQR) radiation dose was significantly lower in the high-pitch cohort (dose-length product: 347 (318-476) vs 1227 (1150-1474) mGy cm, respectively, p < 0.001), and the protocol required almost half the amount of contrast. Conclusions The high-pitch protocol significantly reduces radiation and contrast doses and is non-inferior to standard-pitch acquisitions for aortic assessment. For aortic root assessment, the high-pitch protocol is recommended. However, if coronary assessment is critical, this should be followed by a conventional standard-pitch, low-dose, prospectively gated CT-coronary angiogram if the high-pitch scan is non-diagnostic.

Journal article

Moser JB, Mak SM, McNulty WH, Padley S, Nair A, Shah PL, Devaraj Aet al., 2017, The influence of inspiratory effort and emphysema on pulmonary nodule volumetry reproducibility, Clinical Radiology, Vol: 72, Pages: 925-929, ISSN: 0009-9260

AimTo evaluate the impact of inspiratory effort and emphysema on reproducibility of pulmonary nodule volumetry.Materials and methodsEighty-eight nodules in 24 patients with emphysema were studied retrospectively. All patients had undergone volumetric inspiratory and end-expiratory thoracic computed tomography (CT) for consideration of bronchoscopic lung volume reduction. Inspiratory and expiratory nodule volumes were measured using commercially available software. Local emphysema extent was established by analysing a segmentation area extended circumferentially around each nodule (quantified as percent of lung with density of –950 HU or less). Lung volumes were established using the same software. Differences in inspiratory and expiratory nodule volumes were illustrated using the Bland–Altman test. The influences of percentage reduction in lung volume at expiration, local emphysema extent, and nodule size on nodule volume variability were tested with multiple linear regression.ResultsThe majority of nodules (59/88 [67%]) showed an increased volume at expiration. Mean difference in nodule volume between expiration and inspiration was +7.5% (95% confidence interval: –24.1, 39.1%). No relationships were demonstrated between nodule volume variability and emphysema extent, degree of expiration, or nodule size.ConclusionExpiration causes a modest increase in volumetry-derived nodule volumes; however, the effect is unpredictable. Local emphysema extent had no significant effect on volume variability in the present cohort.

Journal article

Schlosser TPC, Semple T, Carr SB, Padley S, Loebinger MR, Hogg C, Castelein RMet al., 2017, Scoliosis convexity and organ anatomy are related, EUROPEAN SPINE JOURNAL, Vol: 26, Pages: 1595-1599, ISSN: 0940-6719

Journal article

Semple T, Calder A, Owens CM, Padley Set al., 2017, Current and future approaches to large airways imaging in adults and children, CLINICAL RADIOLOGY, Vol: 72, Pages: 356-374, ISSN: 0009-9260

Journal article

Semple T, Minden T, Gartland N, Castellano I, Holubinka M, Rubens M, Padley S, Owens CM, Nicol Eet al., 2017, PAEDIATRIC CARDIAC CT - CURRENT STATE OF PLAY AND ROOM FOR IMPROVEMENT, Annual Spring Meeting of the British-Society-of-Cardiovascular-Imaging/British-Society-of-Cardiovascular-CT (BSCI/BSCCT), Publisher: BMJ PUBLISHING GROUP, Pages: A5-A5, ISSN: 1355-6037

Conference paper

Javed M, Sheard S, Robbie H, Semple T, Padley S, Devaraj Aet al., 2017, Two year audit of CT-guided biopsy for lung cancer in emphysema and fibrotic interstitial lung disease patients, LUNG CANCER, Vol: 103, Pages: S16-S17, ISSN: 0169-5002

Journal article

Hadjiphilippou S, Shah PL, Rice A, Padley S, Hind Met al., 2016, Bronchial Dieulafoy lesion. A 20-year history of unexplained hemoptysis, American Journal of Respiratory and Critical Care Medicine, Vol: 195, Pages: 397-397, ISSN: 1073-449X

Journal article

White SK, Castellano E, Gartland N, Patel T, Padley SPG, Rubens MB, Nicol EDet al., 2016, Quality assurance in cardiovascular CT: a practical guide, CLINICAL RADIOLOGY, Vol: 71, Pages: 729-738, ISSN: 0009-9260

Journal article

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