Dr Salvatore Papa

Pham CG, Bubici C, Zazzeroni F, Papa S, Jones J, Alvarez K, Jayawardena S, De Smaele E, Cong R, Beaumont C, Torti FM, Torti SV, Franzoso Get al., 2004, Ferritin heavy chain upregulation by NF-κB inhibits TNFα-induced apoptosis by suppressing reactive oxygen species, CELL, Vol: 119, Pages: 529-542, ISSN: 0092-8674

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• Citations: 516

Papa S, Zazzeroni F, Pham CG, Bubici C, Franzoso Get al., 2004, Linking JNK signaling to NF-κB:: a key to survival, JOURNAL OF CELL SCIENCE, Vol: 117, Pages: 5197-5208, ISSN: 0021-9533

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• Citations: 231

Bubici C, Papa S, Pham CG, Zazzeroni F, Franzoso Get al., 2004, NF-κB and JNK: an intricate affair., Cell Cycle, Vol: 359, Pages: 1524-1529

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Papa S, Zazzeroni F, Bubici C, Jayawardena S, Alvarez K, Matsuda S, Nguyen DU, Pham CG, Nelsbach AH, Melis T, De Smaele E, Tang W-J, D'Adamio L, Franzoso Get al., 2004, Gadd45{beta} mediates the NF-kappaB suppression of JNK signalling by targeting MKK7/JNKK2., Nat. Cell Biol., Vol: 6, Pages: 146-153

NF-kappa B/Rel transcription factors control apoptosis, also known as programmed cell death. This control is crucial for oncogenesis, cancer chemo-resistance and for antagonizing tumour necrosis factor alpha (TNFalpha)-induced killing. With regard to TNFalpha, the anti-apoptotic activity of NF-kappa B involves suppression of the c-Jun N-terminal kinase (JNK) cascade. Using an unbiased screen, we have previously identified Gadd45{beta}/Myd118, a member of the Gadd45 family of inducible factors, as a pivotal mediator of this suppressive activity of NF-kappaB. However, the mechanisms by which Gadd45{beta} inhibits JNK signalling are not understood. Here, we identify MKK7/JNKK2--a specific and essential activator of JNK--as a target of Gadd45 beta, and in fact, of NF-kappa B itself. Gadd45{beta} binds to MKK7 directly and blocks its catalytic activity, thereby providing a molecular link between the NF-kappaB and JNK pathways. Importantly, Gadd45{beta} is required to antagonize TNFalpha-induced cytotoxicity, and peptides disrupting the Gadd45{beta}/MKK7 interaction hinder the ability of Gadd45{beta}, as well as of NF-kappaB, to suppress this cytotoxicity. These findings establish a basis for the NF-kappaB control of JNK activation and identify MKK7 as a potential target for anti-inflammatory and anti-cancer therapy.

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Zazzeroni F, Papa S, Algeciras-Schimnich A, Alvarez K, Melis T, Bubici C, Majewski N, Hay N, De Smaele E, Peter ME, Franzoso Get al., 2003, Gadd45β mediates the protective effects of CD40 costimulation against Fas-induced apoptosis, BLOOD, Vol: 102, Pages: 3270-3279, ISSN: 0006-4971

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• Citations: 73

Zazzeroni F, Papa S, De Smaele E, Franzoso Get al., 2003, Cell signalling (communication arising) - Cell survival and a Gadd45-factor deficiency - Reply, NATURE, Vol: 424, Pages: 742-742, ISSN: 0028-0836

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• Citations: 8

Franzoso G, De Smaele E, Zazzeroni F, Papa Set al., 2003, Methods and compositions for modulating apoptosis, WO/2003/028659

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Franzoso G, Zazzeroni F, Papa S, 2003, JNK: a killer on a transcriptional leash., Cell Death Differ., Vol: 10, Pages: 13-15

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Jin RG, De Smaele E, Zazzeroni F, Nguyen DU, Papa S, Jones J, Cox C, Gelinas C, Franzoso Get al., 2002, Regulation of the <i>gadd45</i>β promoter by NF-κB, DNA AND CELL BIOLOGY, Vol: 21, Pages: 491-503, ISSN: 1044-5498

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• Citations: 61

De Smaele E, Zazzeroni F, Papa S, Nguyen DU, Jin RG, Jones J, Cong R, Franzoso Get al., 2002, Induction of gadd45β by NF-κB down-regulates pro-apoptotic JNK signaling, Publisher: FEDERATION AMER SOC EXP BIOL, Pages: A139-A139, ISSN: 0892-6638

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• Citations: 1

De Smaele E, Zazzeroni F, Papa S, Nguyen DU, Jin RG, Jones J, Cong R, Franzoso Get al., 2001, Induction of <i>gadd45β</i> by NF-κB downregulates pro-apoptotic JNK signalling, NATURE, Vol: 414, Pages: 308-313, ISSN: 0028-0836

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• Citations: 627