Imperial College London
Alternate

Dr Salvatore Papa

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Honorary Research Fellow
 
 
 
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Contact

 

+44 (0)20 3313 8282s.papa

 
 
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Location

 

10N.13Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@inproceedings{Papa:2009:10.1515/BC.2009.111,
author = {Papa, S and Bubici, C and Zazzeroni, F and Franzoso, G},
doi = {10.1515/BC.2009.111},
pages = {965--976},
publisher = {De Gruyter},
title = {Mechanisms of liver disease: cross-talk between the NF-kappa B and JNK pathways},
url = {http://dx.doi.org/10.1515/BC.2009.111},
year = {2009}
}
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RIS format (EndNote, RefMan)

TY  - CPAPER
AB  - The  liver  plays  a  central  role  in  the  transformation anddegradation  of  endogenous  and  exogenous  chemicals,and in the removal of unwanted cells such as damaged,genetically mutated and virus-infected cells. Because ofthis  function,  the  liver  is  susceptible  to  toxicity causedby  the  products  generated  during  these  natural  occur-rences.  Hepatocyte  death  is  the  major  feature  of  liverinjury.  In  response  to  liver  injury,  specific  intracellularprocesses are initiated to maintain liver integrity. Inflam-matory cytokines including tumor necrosis factor (TNF)aand interleukin-6 (IL-6) are key mediators of these pro-cesses  and  activate  different  cellular response such asproliferation,  survival and death. TNFainduces specificsignaling pathways in hepatocytes that lead to activationof either pro-survival mediators or effectors of cell death.Whereas  activation  of  transcription  factor  NF-kBpro-motes  survival,  c-Jun  N-terminal  kinases  (JNKs)  andcaspases  are  strategic  effectors  of  cell  death  in  theTNFa-mediated signaling pathway. This review summa-rizes  recent  advances  in  the  mechanisms  of  TNFa-induced hepatotoxicity and suggests that NF-kB plays aprotective  role  against  JNK-induced  hepatocyte  death.Identification   of   the   mechanisms  regulating  interplaybetween the NF-kB and JNK pathways is required in thesearch for novel targets for the treatment of liver disease,including hepatitis and hepatocellular carcinoma.
AU  - Papa,S
AU  - Bubici,C
AU  - Zazzeroni,F
AU  - Franzoso,G
DO  - 10.1515/BC.2009.111
EP  - 976
PB  - De Gruyter
PY  - 2009///
SN  - 1431-6730
SP  - 965
TI  - Mechanisms of liver disease: cross-talk between the NF-kappa B and JNK pathways
UR  - http://dx.doi.org/10.1515/BC.2009.111
UR  - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000269983500003&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://www.degruyter.com/document/doi/10.1515/BC.2009.111/html
UR  - http://hdl.handle.net/10044/1/99762
ER  -
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