Imperial College London
Alternate

Dr Salvatore Papa

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Honorary Research Fellow
 
 
 
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Contact

 

+44 (0)20 3313 8282s.papa

 
 
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Location

 

10N.13Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Manka:2018:10.1016/j.canlet.2018.01.055,
author = {Manka, P and Coombes, JD and Boosman, R and Gauthier, K and Papa, S and Syn, WK},
doi = {10.1016/j.canlet.2018.01.055},
journal = {Cancer Letters},
pages = {175--186},
title = {Thyroid hormone in the regulation of hepatocellular carcinoma and its microenvironment},
url = {http://dx.doi.org/10.1016/j.canlet.2018.01.055},
volume = {419},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Hepatocellular carcinoma (HCC) commonly arises from a liver damaged by extensive inflammation and fibrosis. Various factors including cytokines, morphogens, and growth factors are involved in the crosstalk between HCC cells and the stromal microenvironment. Increasing our understanding of how stromal components interact with HCC and the signaling pathways involved could help identify new therapeutic and/or chemopreventive targets. It has become increasingly clear that the cross-talk between tumor cells and host stroma plays a key role in modulating tumor growth. Emerging reports suggest a relationship between HCC and thyroid hormone signaling (dysfunction), raising the possibility that perturbed thyroid hormone (TH) regulation influences the cancer microenvironment and cancer phenotype. This review provides an overview of the role of thyroid hormone and its related pathways in HCC and, specifically, its role in regulating the tumor microenvironment.
AU  - Manka,P
AU  - Coombes,JD
AU  - Boosman,R
AU  - Gauthier,K
AU  - Papa,S
AU  - Syn,WK
DO  - 10.1016/j.canlet.2018.01.055
EP  - 186
PY  - 2018///
SN  - 0304-3835
SP  - 175
TI  - Thyroid hormone in the regulation of hepatocellular carcinoma and its microenvironment
T2  - Cancer Letters
UR  - http://dx.doi.org/10.1016/j.canlet.2018.01.055
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000427102300018&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/64269
VL  - 419
ER  -
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