Imperial College London

Dr Sofia Pappa MD, Ph.D

Faculty of MedicineDepartment of Brain Sciences

Honorary Senior Lecturer
 
 
 
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s.pappa

 
 
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Location

 

Charing Cross HospitalCharing Cross Campus

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Summary

 

Publications

Publication Type
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43 results found

O'Driscoll C, Shaikh M, Finamore C, Platt B, Pappa S, Saunders Ret al., 2021, Profiles and trajectories of mental health service utilisation during early intervention in psychosis., Schizophr Res, Vol: 237, Pages: 47-53

BACKGROUND: Early intervention in psychosis services (EIS) support individuals experiencing a first episode of psychosis. Support required will vary in response to the remittance and reoccurrence of symptoms, including relapses. Characterising individuals who will need more intensive support can inform care planning. This study explores service utilisation profiles and their trajectories of service use in a sample of individuals referred to EIS. METHOD: We analysed service utilisation during the 3 years following referral to EIS (n = 2363) in West London between 2011 and 2020. Mental health service utilisation data were submitted to model-based clustering. Latent growth models were then estimated for identified profiles. Profiles were compared regarding clinical and demographic characteristics and onward pathways of care. RESULTS: Analyses revealed 5 profiles of individuals attending EIS based on their service utilisation over 3 years. 55.5% of the sample were members of a low utilisation and less clinically severe profile. The distinct service use patterns of these profiles were associated with Health of the Nations Outcome Scale scores at treatment initiation (at total, subscale, and individual item level), along with age and gender. These patterns of use were also associated with onward care and ethnicity. CONCLUSIONS: Profiles and trajectories of service utilisation call for development of integrated care pathways and use of more personalised interventions. Services should consider patient symptoms and characteristics when making clinical decisions informing the provision of care. The profiles represent typical patterns of service use, and identifying factors associated with these subgroups might help optimise EIS support.

Journal article

Dewa L, Kalniunas A, Orleans-Foli S, Pappa S, Aylin Pet al., 2021, Detecting signs of deterioration in young patients with serious mental illness: a systematic review, Systematic Reviews, ISSN: 2046-4053

BackgroundSerious mental illnesses (SMI) such as schizophrenia and bipolar disorder first develop between ages 14-25. Once diagnosed, young peoples’ health can deteriorate, and it is therefore vital to detect this early to prevent severe outcomes including hospitalisations and deaths by suicide. The main study aim is to describe and discuss observational studies that examine signs of deterioration in young patients with SMI. MethodsA systematic review guided by the published protocol was conducted. Cumulative Index to Nursing and allied Health Literature (CINAHL), MEDLINE, Embase, PsycINFO, Health Management Information Consortium (HMIC) and Web of Science were searched against pre-defined criteria until March 1st 2021. Observational studies were extracted according to design, country, participant, indicator, outcome and main finding categories. Quality was assessed independently using the Newcastle Ottawa Scale (NOS). ResultsOf the 15788 publications identified, 5 studies were included and subjected to narrative synthesis. Two indicators of mental health deterioration were identified: cognitive functioning (decline, worsening and poor school/academic performance) and expressed emotion status. Indicators revealed mixed views on predicting deterioration. Worsening cognitive functioning and expressed emotion status significantly predicted medication non-adherence and relapse respectively. However, a decline in cognitive functioning (poor academic performance) was not found to significantly correlate to deaths by suicide. Study quality was mostly poor and associations between indicators and varied outcomes were weak. The heterogeneous nature of the data made comparisons difficult and did not allow for further statistical analysis. ConclusionTo our knowledge, this is the first review of observational studies to identify indicators of deterioration in young patients with SMI. Worsening cognitive functioning and expressed emotion status could indicate non-adherence

Journal article

Pappa S, Sakkas N, Sakka E, 2021, A year in review: sleep dysfunction and psychological distress in healthcare workers during the COVID-19 pandemic., Sleep Med

The Covid-19 outbreak has taken a substantial toll on the mental and physical wellbeing of healthcare workers (HCWs), impacting healthcare systems at a global scale. One year into the pandemic, the need to establish the prevalence of sleep dysfunction and psychological distress in the face of COVID-19, identify risk and protective factors and explore effective countermeasures remains of critical importance. Despite implicit limitations relating to the quality of available studies, a plethora of evidence to-date suggests that a considerable proportion of HCWs experience significant sleep disturbances (estimated to afflict every two in five HCWs) as well as mood symptoms (with more than one in five reporting high levels of depression or anxiety). Younger age, female gender, frontline status, fear or risk of infection, occupation, current or past mental health concerns, and a lower level of social support were all associated with a greater risk of disturbed sleep and adverse psychological outcomes. Furthermore, we discuss the link between sleep deprivation, susceptibility to viral infections and psychosocial wellbeing, in relevance to COVID-19 and summarize the existing evidence regarding the presence and predictors of traumatic stress/PTSD and burnout in HCWs. Finally, we highlight the role of resilience and tailored interventions in order to mitigate vulnerability and prevent long-term physical and psychological implications. Indeed, promoting psychological resilience through an enhanced social support network has proven crucial for HCWs in coping under these strenuous circumstances. Future research should aim to provide high quality information on the long-term consequences and the effectiveness of applied interventions.

Journal article

Mason K, Barnett J, Pappa S, 2021, Effectiveness of 2-year treatment with aripiprazole long-acting injectable and comparison with paliperidone palmitate, THERAPEUTIC ADVANCES IN PSYCHOPHARMACOLOGY, Vol: 11, ISSN: 2045-1253

Journal article

Dewa L, Lawrence-Jones A, Kalorkoti C, Jaques J, Pickles K, Lavelle M, Pappa S, Aylin Pet al., 2021, Reflections, impact and recommendations of a co-produced qualitative study with young people who have experience of mental health difficulties, Health Expectations, Vol: 24, Pages: 134-146, ISSN: 1369-6513

BackgroundThere is limited evidence of genuine equal partnership where power is shared with young people with mental health difficulties throughout all research stages, particularly in data collection and analysis.ObjectiveTo describe how our qualitative study, exploring young peoples’ perceptions on the feasibility of using technology to detect mental health deterioration, was co-produced using principles of co-production, whilst reflecting on impact, challenges and recommendations.MethodsYoung people with experience of mental health difficulties were appointed and then worked with researchers throughout all research stages. The study was evaluated against the five principles of co-production. Reflections from researchers and young people were collected throughout.ResultsSeven young people formed an initial Young People's Advisory Group (YPAG); three became co-researchers. Reflection was key throughout the process. Sharing power became easier and more evident as trust, confidence and mutual respect grew over time, particularly after a safe space was established. The safe space was crucial for open discussions, and our WhatsApp group enabled continual communication, support and shared decision-making. The resulting co-produced topic guide, coding framework, thematic map, papers and presentations demonstrated significant impact.ConclusionsTo our knowledge, this is the first qualitative mental health study to be co-produced using the principles of co-production. Our rigorous assessment can be utilized as an informative document to help others to produce meaningful co-produced future research. Although co-production takes time, it makes significant impact to the research, researchers and co-researchers. Flexible funding for spontaneous suggestions from co-researchers and more time for interview training is recommended.

Journal article

Pappa S, Barnett J, Berges I, Sakkas Net al., 2021, Tired, Worried and Burned Out, but Still Resilient: A Cross-Sectional Study of Mental Health Workers in the UK during the COVID-19 Pandemic, INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, Vol: 18

Journal article

Pappa S, Athanasiou N, Sakkas N, Patrinos S, Sakka E, Barmparessou Z, Tsikrika S, Adraktas A, Pataka A, Migdalis I, Gida S, Katsaounou Pet al., 2021, From Recession to Depression? Prevalence and Correlates of Depression, Anxiety, Traumatic Stress and Burnout in Healthcare Workers during the COVID-19 Pandemic in Greece: A Multi-Center, Cross-Sectional Study, INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, Vol: 18

Journal article

Pappa S, Barnett J, Gomme S, Iliopoulou A, Moore I, Whitaker M, McGrath J, Sie Met al., 2021, Shared and Supported Decision Making in Medication in a Mental Health Setting: How Far Have We Come?, COMMUNITY MENTAL HEALTH JOURNAL, ISSN: 0010-3853

Journal article

Pappa S, Ntella V, Giannakas T, Giannakoulis VG, Papoutsi E, Katsaounou Pet al., 2021, Prevalence of depression, anxiety, and insomnia among healthcare workers during the COVID-19 pandemic: A systematic review and meta-analysis (vol 88, pg 901, 2020), BRAIN BEHAVIOR AND IMMUNITY, Vol: 92, Pages: 245-245, ISSN: 0889-1591

Journal article

Pappa S, Giannakoulis VG, Papoutsi E, Katsaounou Pet al., 2021, Author reply - Letter to the editor "The challenges of quantifying the psychological burden of COVID-19 on heathcare workers", BRAIN BEHAVIOR AND IMMUNITY, Vol: 92, Pages: 209-210, ISSN: 0889-1591

Journal article

Puntis S, Whiting D, Pappa S, Lennox Bet al., 2021, Development and external validation of an admission risk prediction model after treatment from early intervention in psychosis services, TRANSLATIONAL PSYCHIATRY, Vol: 11, ISSN: 2158-3188

Journal article

Pappa S, Mason K, Barnett J, 2020, A five-year follow up study of a naturalistic cohort treated with long-acting injectable antipsychotics, 33rd Congress of the European-College-of-Neuropsychopharmacology (ECNP), Publisher: ELSEVIER, Pages: S471-S471, ISSN: 0924-977X

Conference paper

Pappa S, Barnett J, Mason K, 2020, Real-world effectiveness of aripiprazole long-acting injectable, 33rd Congress of the European-College-of-Neuropsychopharmacology (ECNP), Publisher: ELSEVIER, Pages: S472-S472, ISSN: 0924-977X

Conference paper

Pappa S, Patrinos S, Sakkas N, Osarogue A, Sakka E, Filippidis F, Katsaounou Pet al., 2020, COPD patients continue to smoke after being diagnosed for COPD, Publisher: EUROPEAN RESPIRATORY SOC JOURNALS LTD, ISSN: 0903-1936

Conference paper

Korkontzelou A, Driva S, Schoretsaniti S, Gyftopoulos S, Vasileiou V, Barbaressou Z, Osarogue A, Saltagianni V, Andritsou M, Pappa S, Papadopoulou V, Tonstad S, Gratziou C, Tentolouris N, Katsaounou Pet al., 2020, Smoking cessation in patients with Diabetes Mellitus (DM), Publisher: EUROPEAN RESPIRATORY SOC JOURNALS LTD, ISSN: 0903-1936

Conference paper

Pappa S, Patrinos S, Sakka E, Sakkas N, Osarogue A, Filipidis F, Katsaounou Pet al., 2020, Mental health disorders as barries to quit for asthmatic smokers, Publisher: EUROPEAN RESPIRATORY SOC JOURNALS LTD, ISSN: 0903-1936

Conference paper

Barmparessou Z, Korkontzelou A, Ioannou M, Vichos N, Gkotsina M, Mprinia K, Saltagianni V, Giannakas T, Giannakoulis V, Athanasiou N, Antonoglou A, Kakavas S, Boulia S, Boulbasakos G, Gida S, Pappa S, Zervas E, Kalomenidis I, Katsaounou Pet al., 2020, The majority of patients that suffer an asthma attack at the Emergency Room (ER) are mild asthmatics, Publisher: EUROPEAN RESPIRATORY SOC JOURNALS LTD, ISSN: 0903-1936

Conference paper

Crawford MJ, Thana L, Evans R, Carne A, O'Connell L, Claringbold A, Saravanamuthu A, Case R, Munjiza J, Jayacodi S, Reilly JG, Hughes E, Hoare Z, Barrett B, Leeson VC, Paton C, Keown P, Pappa S, Green C, Barnes TREet al., 2020, Switching antipsychotic medication to reduce sexual dysfunction in people with psychosis: the REMEDY RCT, HEALTH TECHNOLOGY ASSESSMENT, Vol: 24, Pages: 1-+, ISSN: 1366-5278

Journal article

Pappa S, Ntella V, Giannakas T, Giannakoulis VG, Papoutsi E, Katsaounou Pet al., 2020, Prevalence of depression, anxiety, and insomnia among healthcare workers during the COVID-19 pandemic: A systematic review and meta-analysis, BRAIN BEHAVIOR AND IMMUNITY, Vol: 88, Pages: 901-907, ISSN: 0889-1591

Journal article

Brinia A, Barmparessou Z, Vichos N, Giannakoulis V, Giannakas T, Gida S, Saltagianni V, Pappa S, Korkontzelou A, Athanasiou N, Kakavas S, Ioannou M, Boulbasakos G, Kalomenidis I, Katsaounou Pet al., 2020, Characteristics of patients admitted with asthma attacks in the emergency department of a University Hospital, European-Academy-of-Allergology-and-Clinical-Immunology Digital Congress (EAACI), Publisher: WILEY, Pages: 409-410, ISSN: 0105-4538

Conference paper

Attal J, Lahaye M, Leopold K, Marsella C, Pappa S, Pungor K, Sanchez P, Steegen G, Verrijcken C, Vita A, Wooller Aet al., 2020, Patient, investigator, nurse, carer questionnaire (PINC-Q): exploring the impact of paliperidone palmitate 3-monthly administration in the maintenance treatment of schizophrenia from four key stakeholders, Publisher: CAMBRIDGE UNIV PRESS, Pages: S256-S257, ISSN: 0924-9338

Conference paper

Pappa S, Mason K, 2020, Partial compliance with long-acting paliperidone palmitate and impact on hospitalization: a 6-year mirror-image study, THERAPEUTIC ADVANCES IN PSYCHOPHARMACOLOGY, Vol: 10, ISSN: 2045-1253

Journal article

Allen K, Baban A, Munjiza J, Pappa Set al., 2020, DOES SWITCHING OR AUGMENTING HELP WITH ANTIPSYCHOTIC-RELATED SEXUAL DYSFUNCTION: SYSTEMATIC REVIEW, Congress of the Schizophrenia-International-Research-Society (SRIS), Publisher: OXFORD UNIV PRESS, Pages: S30-S31, ISSN: 0586-7614

Conference paper

Papoutsi E, Giannakoulis VG, Ntella V, Pappa S, Katsaounou Pet al., 2020, Global burden of COVID-19 pandemic on healthcare workers, ERJ OPEN RESEARCH, Vol: 6

Journal article

Javed A, Arthur H, Curtis L, Hansen L, Pappa Set al., 2019, Practical guidance on the use of lurasidone for the treatment of adults with schizophrenia, Neurology and Therapy, Vol: 8, Pages: 215-230, ISSN: 2193-8253

IntroductionLurasidone is an atypical antipsychotic that was approved in Europe in 2014 for the treatment of schizophrenia in adults aged ≥ 18 years. Clinical experience with lurasidone in Europe is currently limited, and there is therefore a need to provide practical guidance on using lurasidone for the treatment of adults with schizophrenia.MethodsA panel of European psychiatrists with extensive experience of prescribing lurasidone was convened to provide recommendations on using lurasidone to treat adults with schizophrenia.ResultsExtensive evidence from clinical trials and the panel’s clinical experience suggest that lurasidone is as effective as other atypical agents, with the possible exception of clozapine. Lurasidone is associated with a lower propensity for metabolic side effects (in particular, weight gain) and hyperprolactinaemia than most other atypical antipsychotics and has a relatively benign neurocognitive side effect profile. Patients switching to lurasidone from another antipsychotic may experience weight reduction and/or improvements in the ability to focus/concentrate. Most side effects with lurasidone (such as somnolence) are transitory, easily managed and/or ameliorated by dose adjustment. Akathisia and extrapyramidal symptoms may occur in a minority of patients, but these can be managed effectively with dose adjustment, adjunctive therapy and/or psychosocial intervention.ConclusionsGiven the crucial importance of addressing the physical as well as mental healthcare needs of patients, lurasidone is a rational therapeutic choice for adults with schizophrenia, both in the acute setting and over the long term.FundingSunovion Pharmaceuticals Europe Ltd.

Journal article

Allen K, Baban A, Munjiza J, Pappa Set al., 2019, Management of Antipsychotic-Related Sexual Dysfunction: Systematic Review, JOURNAL OF SEXUAL MEDICINE, Vol: 16, Pages: 1978-1987, ISSN: 1743-6095

Journal article

Pappa S, Mason K, Howard E, 2019, Long-term effects of paliperidone palmitate on hospital stay and treatment continuation, INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY, Vol: 34, Pages: 305-311, ISSN: 0268-1315

Journal article

Dewa L, Lavelle M, Pickles K, Jaques J, Kalorkoti C, Pappa S, Aylin Pet al., 2019, Young adults’ perceptions of using wearables, social media and other technologies to detect worsening mental health: a qualitative study, PLoS One, Vol: 14, ISSN: 1932-6203

BackgroundTechnological interventions may help support and improve mental health. However young peoples’ perspectives on using different technologies to detect deteriorating mental health in those already diagnosed with a mental health condition is lacking. The study aim was to explore the perspectives of young patients on the feasibility and acceptability of using wearables, social media and technologies to detect mental health deterioration. Methods The study was co-produced with young adults with past mental health difficulties. Semi-structured interviews were conducted with young adults with a severe mental health condition in a private room at a community mental health site. Data was triangulated by comparing codes and ideas across the two co-researchers and two researchers over two virtual meetings. Themes were finalised and presented in a thematic map. ResultsSixteen participants were interviewed (81% female). There were four main themes: dealing with mental health symptoms, signs of mental health deterioration, technology concerns and technological applications to identify worsening mental health. Wearables and mobile apps were considered acceptable and feasible to detect mental health deterioration in real-time if they could measure changes in sleep patterns, mood or activity levels as signs of deterioration. Getting help earlier was deemed essential particularly in reference to dissatisfaction with the current non-technological mental health services. However, patients identified issues to consider before implementation including practicality, safeguarding and patient preference. ConclusionWearables and mobile apps could be viable technological options to help detect deterioration in young people in order to intervene early and avoid delay in accessing mental health services. However, immediate action following detection is required for the patient to trust and use the intervention.

Journal article

Hidalgo-Mazzei D, Berk M, Cipriani A, Cleare AJ, Di Florio A, Dietch D, Geddes JR, Goodwin GM, Grunze H, Hayes JF, Jones I, Kasper S, Macritchie K, McAllister-Williams RH, Morriss R, Nayrouz S, Pappa S, Soares JC, Smith DJ, Suppes T, Talbot P, Vieta E, Watson S, Yatham LN, Young AH, Stokes PRAet al., 2019, Treatment-resistant and Multi-therapy resistant criteria for bipolar depression: A consensus definition (vol 214, pg 27, 2019), BRITISH JOURNAL OF PSYCHIATRY, Vol: 214, Pages: 309-309, ISSN: 0007-1250

Journal article

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