Imperial College London

Dr Sofia Pappa MD, Ph.D

Faculty of MedicineDepartment of Brain Sciences

Honorary Senior Lecturer
 
 
 
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Contact

 

s.pappa

 
 
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Location

 

Charing Cross HospitalCharing Cross Campus

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Summary

 

Publications

Publication Type
Year
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54 results found

Dewa LH, Pappa S, Greene T, Cooke J, Mitchell L, Hadley M, Di Simplicio M, Woodcock T, Aylin Pet al., 2022, The Association Between Sleep Disturbance and Suicidality in Psychiatric Inpatients Transitioning to the Community: Protocol for an Ecological Momentary Assessment Study., JMIR Res Protoc, Vol: 11, ISSN: 1929-0748

BACKGROUND: Patients are at high risk of suicidal behavior and death by suicide immediately following discharge from inpatient psychiatric hospitals. Furthermore, there is a high prevalence of sleep problems in inpatient settings, which is associated with worse outcomes following hospitalization. However, it is unknown whether poor sleep is associated with suicidality following initial hospital discharge. OBJECTIVE: Our study objective is to describe a protocol for an ecological momentary assessment (EMA) study that aims to examine the relationship between sleep and suicidality in discharged patients. METHODS: Our study will use an EMA design based on a wearable device to examine the sleep-suicide relationship during the transition from acute inpatient care to the community. Prospectively discharged inpatients 18 to 35 years old with mental disorders (N=50) will be assessed for eligibility and recruited across 2 sites. Data on suicidal ideation, behavior, and imagery; nonsuicidal self-harm and imagery; defeat, entrapment, and hopelessness; affect; and sleep will be collected on the Pro-Diary V wrist-worn electronic watch for up to 14 days. Objective sleep and daytime activity will be measured using the inbuilt MotionWare software. Questionnaires will be administered face-to-face at baseline and follow up, and data will also be collected on the acceptability and feasibility of using the Pro-Diary V watch to monitor the transition following discharge. The study has been, and will continue to be, coproduced with young people with experience of being in an inpatient setting and suicidality. RESULTS: South Birmingham Research Ethics Committee (21/WM/0128) approved the study on June 28, 2021. We expect to see a relationship between poor sleep and postdischarge suicidality. Results will be available in 2022. CONCLUSIONS: This protocol describes the first coproduced EMA study to examine the relationship between sleep and suicidality and to apply the integrated motivational

Journal article

Dewa L, Pappa S, Greene T, Cooke J, Mitchell L, Hadley M, Di Simplicio M, Woodcock T, Aylin Pet al., 2022, SWAY: Associations between sleep disturbance and suicidality in psychiatric inpatients transitioning to the community: an ecological momentary assessment study protocol, JMIR Research Protocols, ISSN: 1929-0748

Journal article

Pappa S, Barmparessou Z, Athanasiou N, Sakka E, Eleftheriou K, Patrinos S, Sakkas N, Pappas A, Kalomenidis I, Katsaounou Pet al., 2022, Depression, Insomnia and Post-Traumatic Stress Disorder in COVID-19 Survivors: Role of Gender and Impact on Quality of Life, JOURNAL OF PERSONALIZED MEDICINE, Vol: 12

Journal article

Pappa S, Sakkas N, Sakka E, 2022, A year in review: sleep dysfunction and psychological distress in healthcare workers during the COVID-19 pandemic., Sleep Med, Vol: 91, Pages: 237-245

The Covid-19 outbreak has taken a substantial toll on the mental and physical wellbeing of healthcare workers (HCWs), impacting healthcare systems at a global scale. One year into the pandemic, the need to establish the prevalence of sleep dysfunction and psychological distress in the face of COVID-19, identify risk and protective factors and explore effective countermeasures remains of critical importance. Despite implicit limitations relating to the quality of available studies, a plethora of evidence to-date suggests that a considerable proportion of HCWs experience significant sleep disturbances (estimated to afflict every two in five HCWs) as well as mood symptoms (with more than one in five reporting high levels of depression or anxiety). Younger age, female gender, frontline status, fear or risk of infection, occupation, current or past mental health concerns, and a lower level of social support were all associated with a greater risk of disturbed sleep and adverse psychological outcomes. Furthermore, we discuss the link between sleep deprivation, susceptibility to viral infections and psychosocial wellbeing, in relevance to COVID-19 and summarize the existing evidence regarding the presence and predictors of traumatic stress/PTSD and burnout in HCWs. Finally, we highlight the role of resilience and tailored interventions in order to mitigate vulnerability and prevent long-term physical and psychological implications. Indeed, promoting psychological resilience through an enhanced social support network has proven crucial for HCWs in coping under these strenuous circumstances. Future research should aim to provide high quality information on the long-term consequences and the effectiveness of applied interventions.

Journal article

Barnett J, Mason K, Pappa S, 2021, The relationship between level of compliance with aripiprazole long-acting injectable and risk of hospitalisation, 34th European-College-of-Neuropsychopharmacology (ECNP) Congress on Early Career Scientists in Europe, Publisher: ELSEVIER, Pages: S354-S355, ISSN: 0924-977X

Conference paper

Pappa S, Barmparessou Z, Sakka E, Patrinos S, Sakkas N, Athanasiou N, Kalomenidis I, Katsaounou Pet al., 2021, Effects on mental health, sleep and quality of life in hospitalized patients with COVID-19 infection, 34th European-College-of-Neuropsychopharmacology (ECNP) Congress on Early Career Scientists in Europe, Publisher: ELSEVIER, Pages: S581-S582, ISSN: 0924-977X

Conference paper

Pappa S, Chen J, Barnett J, Chang A, Dong RK, Xu W, Yin A, Chen BZ, Delios AY, Chen RZ, Miller S, Wan X, Zhang SXet al., 2021, A systematic review and meta-analysis of the mental health symptoms during the Covid-19 pandemic in Southeast Asia, PSYCHIATRY AND CLINICAL NEUROSCIENCES, Vol: 76, Pages: 41-50, ISSN: 1323-1316

Journal article

Kalniunas A, Chakrabarti I, Mandalia R, Munjiza J, Pappa Set al., 2021, The association between antipsychotic-induced akathisia and suicidal behaviour: a systematic review, Neuropsychiatric Disease and Treatment, ISSN: 1176-6328

Objective: We aim to systematically review evidence for an association between antipsychotic-induced akathisia and suicidal behaviour, in order to guide further clinical decision making in this area. Methods: Several electronic databases (Embase, Medline, Cochrane and PsychINFO) were systemically searched for articles published up to February 2021, using search terms related to akathisia, antipsychotics and suicidal behaviour. Two reviewers independently evaluated all the relevant studies using pre-determined criteria and assessed the risk of bias for each included study. The systematic review was conducted in line with PRISMA methodology and reporting.Results: Following de-duplication, screening and application of exclusion criteria, four eligible studies were identified. All of the available studies were in English and included adult patients. Nevertheless, there was significant variability regarding methodology and overall quality was deemed low due to small sample sizes. There was insufficient data to perform statistical analyses of the results. Of the four studies, two found a weak correlation between antipsychotic-related akathisia and suicidal behaviour, a finding that was not supported by the remaining two studies. Conclusion: The search yielded very few studies for inclusion. On the basis of the existing evidence, akathisia cannot be reliably linked to the presence of suicidal behaviour in patients treated with antipsychotic medication. However, proactive screening for emerging suicidal behaviour in this vulnerable patient group is advisable. Our findings highlight the pressing need for further research in this area.

Journal article

Pataka A, Kotoulas S, Sakka E, Katsaounou P, Pappa Set al., 2021, Sleep Dysfunction in COVID-19 Patients: Prevalence, Risk Factors, Mechanisms, and Management, JOURNAL OF PERSONALIZED MEDICINE, Vol: 11

Journal article

Dewa L, Pappa S, Greene T, Cooke J, Mitchell L, Hadley M, Di Simplicio M, Woodcock T, Aylin Pet al., 2021, SWAY: Sleep disturbance as an early warning sign of suicidality in psychiatric inpatients transitioning to the community: an ecological momentary assessment study protocol

Working paper

Dewa L, Kalniunas A, Orleans-Foli S, Pappa S, Aylin Pet al., 2021, Detecting signs of deterioration in young patients with serious mental illness: a systematic review, Systematic Reviews, Vol: 10, Pages: 1-8, ISSN: 2046-4053

BackgroundSerious mental illnesses (SMI) such as schizophrenia and bipolar disorder first develop between ages 14-25. Once diagnosed, young peoples’ health can deteriorate, and it is therefore vital to detect this early to prevent severe outcomes including hospitalisations and deaths by suicide. The main study aim is to describe and discuss observational studies that examine signs of deterioration in young patients with SMI. MethodsA systematic review guided by the published protocol was conducted. Cumulative Index to Nursing and allied Health Literature (CINAHL), MEDLINE, Embase, PsycINFO, Health Management Information Consortium (HMIC) and Web of Science were searched against pre-defined criteria until March 1st 2021. Observational studies were extracted according to design, country, participant, indicator, outcome and main finding categories. Quality was assessed independently using the Newcastle Ottawa Scale (NOS). ResultsOf the 15788 publications identified, 5 studies were included and subjected to narrative synthesis. Two indicators of mental health deterioration were identified: cognitive functioning (decline, worsening and poor school/academic performance) and expressed emotion status. Indicators revealed mixed views on predicting deterioration. Worsening cognitive functioning and expressed emotion status significantly predicted medication non-adherence and relapse respectively. However, a decline in cognitive functioning (poor academic performance) was not found to significantly correlate to deaths by suicide. Study quality was mostly poor and associations between indicators and varied outcomes were weak. The heterogeneous nature of the data made comparisons difficult and did not allow for further statistical analysis. ConclusionTo our knowledge, this is the first review of observational studies to identify indicators of deterioration in young patients with SMI. Worsening cognitive functioning and expressed emotion status could indicate non-adherence

Journal article

O'Driscoll C, Shaikh M, Finamore C, Platt B, Pappa S, Saunders Ret al., 2021, Profiles and trajectories of mental health service utilisation during early intervention in psychosis, SCHIZOPHRENIA RESEARCH, Vol: 237, Pages: 47-53, ISSN: 0920-9964

Journal article

Mason K, Barnett J, Pappa S, 2021, Effectiveness of 2-year treatment with aripiprazole long-acting injectable and comparison with paliperidone palmitate, THERAPEUTIC ADVANCES IN PSYCHOPHARMACOLOGY, Vol: 11, ISSN: 2045-1253

Journal article

Pappa S, Barnett J, Berges I, Sakkas Net al., 2021, Tired, Worried and Burned Out, but Still Resilient: A Cross-Sectional Study of Mental Health Workers in the UK during the COVID-19 Pandemic, INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, Vol: 18

Journal article

Dewa L, Lawrence-Jones A, Kalorkoti C, Jaques J, Pickles K, Lavelle M, Pappa S, Aylin Pet al., 2021, Reflections, impact and recommendations of a co-produced qualitative study with young people who have experience of mental health difficulties, Health Expectations, Vol: 24, Pages: 134-146, ISSN: 1369-6513

BackgroundThere is limited evidence of genuine equal partnership where power is shared with young people with mental health difficulties throughout all research stages, particularly in data collection and analysis.ObjectiveTo describe how our qualitative study, exploring young peoples’ perceptions on the feasibility of using technology to detect mental health deterioration, was co-produced using principles of co-production, whilst reflecting on impact, challenges and recommendations.MethodsYoung people with experience of mental health difficulties were appointed and then worked with researchers throughout all research stages. The study was evaluated against the five principles of co-production. Reflections from researchers and young people were collected throughout.ResultsSeven young people formed an initial Young People's Advisory Group (YPAG); three became co-researchers. Reflection was key throughout the process. Sharing power became easier and more evident as trust, confidence and mutual respect grew over time, particularly after a safe space was established. The safe space was crucial for open discussions, and our WhatsApp group enabled continual communication, support and shared decision-making. The resulting co-produced topic guide, coding framework, thematic map, papers and presentations demonstrated significant impact.ConclusionsTo our knowledge, this is the first qualitative mental health study to be co-produced using the principles of co-production. Our rigorous assessment can be utilized as an informative document to help others to produce meaningful co-produced future research. Although co-production takes time, it makes significant impact to the research, researchers and co-researchers. Flexible funding for spontaneous suggestions from co-researchers and more time for interview training is recommended.

Journal article

Pappa S, Athanasiou N, Sakkas N, Patrinos S, Sakka E, Barmparessou Z, Tsikrika S, Adraktas A, Pataka A, Migdalis I, Gida S, Katsaounou Pet al., 2021, From Recession to Depression? Prevalence and Correlates of Depression, Anxiety, Traumatic Stress and Burnout in Healthcare Workers during the COVID-19 Pandemic in Greece: A Multi-Center, Cross-Sectional Study, INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, Vol: 18

Journal article

Pappa S, Ntella V, Giannakas T, Giannakoulis VG, Papoutsi E, Katsaounou Pet al., 2021, Prevalence of depression, anxiety, and insomnia among healthcare workers during the COVID-19 pandemic: A systematic review and meta-analysis (vol 88, pg 901, 2020), BRAIN BEHAVIOR AND IMMUNITY, Vol: 92, Pages: 245-245, ISSN: 0889-1591

Journal article

Pappa S, Giannakoulis VG, Papoutsi E, Katsaounou Pet al., 2021, Author reply - Letter to the editor "The challenges of quantifying the psychological burden of COVID-19 on heathcare workers", BRAIN BEHAVIOR AND IMMUNITY, Vol: 92, Pages: 209-210, ISSN: 0889-1591

Journal article

Pappa S, Barnett J, Gomme S, Iliopoulou A, Moore I, Whitaker M, McGrath J, Sie Met al., 2021, Shared and Supported Decision Making in Medication in a Mental Health Setting: How Far Have We Come?, COMMUNITY MENTAL HEALTH JOURNAL, Vol: 57, Pages: 1566-1578, ISSN: 0010-3853

Journal article

Puntis S, Whiting D, Pappa S, Lennox Bet al., 2021, Development and external validation of an admission risk prediction model after treatment from early intervention in psychosis services, TRANSLATIONAL PSYCHIATRY, Vol: 11, ISSN: 2158-3188

Journal article

Kalniunas A, Chakrabarti I, Mandalia R, Munjiza J, Pappa Set al., 2021, The Relationship Between Antipsychotic-Induced Akathisia and Suicidal Behaviour: A Systematic Review, NEUROPSYCHIATRIC DISEASE AND TREATMENT, Vol: 17, Pages: 3489-3497

Journal article

Pappa S, Mason K, Barnett J, 2020, A five-year follow up study of a naturalistic cohort treated with long-acting injectable antipsychotics, 33rd Congress of the European-College-of-Neuropsychopharmacology (ECNP), Publisher: ELSEVIER, Pages: S471-S471, ISSN: 0924-977X

Conference paper

Pappa S, Barnett J, Mason K, 2020, Real-world effectiveness of aripiprazole long-acting injectable, 33rd Congress of the European-College-of-Neuropsychopharmacology (ECNP), Publisher: ELSEVIER, Pages: S472-S472, ISSN: 0924-977X

Conference paper

Pappa S, Patrinos S, Sakkas N, Osarogue A, Sakka E, Filippidis F, Katsaounou Pet al., 2020, COPD patients continue to smoke after being diagnosed for COPD, Publisher: EUROPEAN RESPIRATORY SOC JOURNALS LTD, ISSN: 0903-1936

Conference paper

Barmparessou Z, Korkontzelou A, Ioannou M, Vichos N, Gkotsina M, Mprinia K, Saltagianni V, Giannakas T, Giannakoulis V, Athanasiou N, Antonoglou A, Kakavas S, Boulia S, Boulbasakos G, Gida S, Pappa S, Zervas E, Kalomenidis I, Katsaounou Pet al., 2020, The majority of patients that suffer an asthma attack at the Emergency Room (ER) are mild asthmatics, Publisher: EUROPEAN RESPIRATORY SOC JOURNALS LTD, ISSN: 0903-1936

Conference paper

Pappa S, Patrinos S, Sakka E, Sakkas N, Osarogue A, Filipidis F, Katsaounou Pet al., 2020, Mental health disorders as barries to quit for asthmatic smokers, Publisher: EUROPEAN RESPIRATORY SOC JOURNALS LTD, ISSN: 0903-1936

Conference paper

Korkontzelou A, Driva S, Schoretsaniti S, Gyftopoulos S, Vasileiou V, Barbaressou Z, Osarogue A, Saltagianni V, Andritsou M, Pappa S, Papadopoulou V, Tonstad S, Gratziou C, Tentolouris N, Katsaounou Pet al., 2020, Smoking cessation in patients with Diabetes Mellitus (DM), Publisher: EUROPEAN RESPIRATORY SOC JOURNALS LTD, ISSN: 0903-1936

Conference paper

Crawford MJ, Thana L, Evans R, Carne A, O'Connell L, Claringbold A, Saravanamuthu A, Case R, Munjiza J, Jayacodi S, Reilly JG, Hughes E, Hoare Z, Barrett B, Leeson VC, Paton C, Keown P, Pappa S, Green C, Barnes TREet al., 2020, Switching antipsychotic medication to reduce sexual dysfunction in people with psychosis: the REMEDY RCT, HEALTH TECHNOLOGY ASSESSMENT, Vol: 24, Pages: 1-+, ISSN: 1366-5278

Journal article

Brinia A, Barmparessou Z, Vichos N, Giannakoulis V, Giannakas T, Gida S, Saltagianni V, Pappa S, Korkontzelou A, Athanasiou N, Kakavas S, Ioannou M, Boulbasakos G, Kalomenidis I, Katsaounou Pet al., 2020, Characteristics of patients admitted with asthma attacks in the emergency department of a University Hospital, European-Academy-of-Allergology-and-Clinical-Immunology Digital Congress (EAACI), Publisher: WILEY, Pages: 409-410, ISSN: 0105-4538

Conference paper

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