Imperial College London
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Dr Sofia Pappa MD, Ph.D

Faculty of Medicine, Department of Brain Sciences

Honorary Senior Lecturer
 
 
 
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Contact

 

s.pappa

 
 
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Location

 

Charing Cross HospitalCharing Cross Campus

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Summary

 

Publications

Citation

BibTex format

@article{Javed:2019:10.1007/s40120-019-0138-z,
author = {Javed, A and Arthur, H and Curtis, L and Hansen, L and Pappa, S},
doi = {10.1007/s40120-019-0138-z},
journal = {Neurology and Therapy},
pages = {215--230},
title = {Practical guidance on the use of lurasidone for the treatment of adults with schizophrenia},
url = {http://dx.doi.org/10.1007/s40120-019-0138-z},
volume = {8},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - IntroductionLurasidone is an atypical antipsychotic that was approved in Europe in 2014 for the treatment of schizophrenia in adults aged ≥ 18 years. Clinical experience with lurasidone in Europe is currently limited, and there is therefore a need to provide practical guidance on using lurasidone for the treatment of adults with schizophrenia.MethodsA panel of European psychiatrists with extensive experience of prescribing lurasidone was convened to provide recommendations on using lurasidone to treat adults with schizophrenia.ResultsExtensive evidence from clinical trials and the panel’s clinical experience suggest that lurasidone is as effective as other atypical agents, with the possible exception of clozapine. Lurasidone is associated with a lower propensity for metabolic side effects (in particular, weight gain) and hyperprolactinaemia than most other atypical antipsychotics and has a relatively benign neurocognitive side effect profile. Patients switching to lurasidone from another antipsychotic may experience weight reduction and/or improvements in the ability to focus/concentrate. Most side effects with lurasidone (such as somnolence) are transitory, easily managed and/or ameliorated by dose adjustment. Akathisia and extrapyramidal symptoms may occur in a minority of patients, but these can be managed effectively with dose adjustment, adjunctive therapy and/or psychosocial intervention.ConclusionsGiven the crucial importance of addressing the physical as well as mental healthcare needs of patients, lurasidone is a rational therapeutic choice for adults with schizophrenia, both in the acute setting and over the long term.FundingSunovion Pharmaceuticals Europe Ltd.
AU  - Javed,A
AU  - Arthur,H
AU  - Curtis,L
AU  - Hansen,L
AU  - Pappa,S
DO  - 10.1007/s40120-019-0138-z
EP  - 230
PY  - 2019///
SN  - 2193-8253
SP  - 215
TI  - Practical guidance on the use of lurasidone for the treatment of adults with schizophrenia
T2  - Neurology and Therapy
UR  - http://dx.doi.org/10.1007/s40120-019-0138-z
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000496695000005&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://link.springer.com/article/10.1007%2Fs40120-019-0138-z#article-info
UR  - http://hdl.handle.net/10044/1/85408
VL  - 8
ER  -
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