Imperial College London
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Dr Sofia Pappa MD, Ph.D

Faculty of Medicine, Department of Brain Sciences

Honorary Senior Lecturer
 
 
 
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Contact

 

s.pappa

 
 
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Location

 

Charing Cross HospitalCharing Cross Campus

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Summary

 

Publications

Citation

BibTex format

@article{Chapman:2022:10.7189/jogh.12.09004,
author = {Chapman, N and Browning, M and Baghurst, D and Hotopf, M and Willis, D and Haylock, S and Zakaria, S and Speechley, J and Withey, J and Brooks, E and Chan, F and Pappa, S and Geddes, J and Insole, L and Mohammed, Z and Kessler, D and Jones, PB and Mansoori, P and Difficult, to Treat Depression Research Priority Setting Group},
doi = {10.7189/jogh.12.09004},
journal = {J Glob Health},
title = {Setting national research priorities for difficult-to-treat depression in the UK between 2021-2026.},
url = {http://dx.doi.org/10.7189/jogh.12.09004},
volume = {12},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BACKGROUND: Difficult-to-treat depression (DTD) presents a substantial health care challenge, with around one-third of people diagnosed with a depressive episode in the UK finding that their symptoms persist following treatment. This study aimed to identify priority research questions (RQs) that could inform the development of new and improved treatments, interventions, and support for people with DTD. METHODS: Using an adapted Child Health and Nutrition Research Initiative (CHNRI) method, this national prioritisation exercise engaged 60 leading researchers and health care professionals in the UK, as well as 25 wider stakeholders with relevant lived experience to produce a ranked list of priority RQs in DTD. The final list of 99 distinct RQs was independently scored by 42 individuals against a list of five criteria: answerability, effectiveness, impact on health, deliverability, and equity. RESULTS: Highly ranked RQs covered a range of novel and existing treatments. The three highest scoring RQs included evaluation of psychological and pharmacological therapies (eg, behavioural activation, and augmentation therapies), as well as social interventions to reduce loneliness or increase support for people with DTD. CONCLUSIONS: This exercise identified and prioritised 99 RQs that could inform future research and funding decisions over the next five years. The results of this research could improve treatment and support for people affected by DTD. It also serves as an example of ways in which the CHNRI method can be adapted in a collaborative manner to provide a more active role for patients, carers, and health care professionals.
AU  - Chapman,N
AU  - Browning,M
AU  - Baghurst,D
AU  - Hotopf,M
AU  - Willis,D
AU  - Haylock,S
AU  - Zakaria,S
AU  - Speechley,J
AU  - Withey,J
AU  - Brooks,E
AU  - Chan,F
AU  - Pappa,S
AU  - Geddes,J
AU  - Insole,L
AU  - Mohammed,Z
AU  - Kessler,D
AU  - Jones,PB
AU  - Mansoori,P
AU  - Difficult,to Treat Depression Research Priority Setting Group
DO  - 10.7189/jogh.12.09004
PY  - 2022///
TI  - Setting national research priorities for difficult-to-treat depression in the UK between 2021-2026.
T2  - J Glob Health
UR  - http://dx.doi.org/10.7189/jogh.12.09004
UR  - https://www.ncbi.nlm.nih.gov/pubmed/36472926
VL  - 12
ER  -
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