Imperial College London
Alternate

DrStevenPatterson

Faculty of Medicine, Department of Infectious Disease

Honorary Principal Research Fellow
 
 
 
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Contact

 

+44 (0)20 3315 5934s.patterson

 
 
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Location

 

I.2.6Chelsea and Westminster HospitalChelsea and Westminster Campus

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Summary

 

Publications

Citation

BibTex format

@article{Benlahrech:2012:10.1111/j.1365-2249.2012.04647.x,
author = {Benlahrech, A and Yasmin, A and Westrop, SJ and Coleman, A and Herasimtschuk, A and Page, E and Kelleher, P and Gotch, F and Imami, N and Patterson, S},
doi = {10.1111/j.1365-2249.2012.04647.x},
journal = {Clinical and Experimental Immunology},
pages = {212--221},
title = {Dysregulated immunophenotypic attributes of plasmacytoid but not myeloid dendritic cells in HIV-1 infected individuals in the absence of highly active anti-retroviral therapy},
url = {http://dx.doi.org/10.1111/j.1365-2249.2012.04647.x},
volume = {170},
year = {2012}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Dendritic cells (DC) in HIV-1-infected individuals are decreased and their dysfunction has been implicated in HIV-1 immunopathogenesis. The mechanism of their dysfunction remains unclear, thus we analysed the expression of membrane molecules associated with immune regulation and DC activation in myeloid (mDC) and plasmacytoid DC (pDC) in therapy-naive and highly active anti-retroviral therapy (HAART)-treated HIV-1+ patients. DC from healthy controls, untreated HIV-1+ and HAART-treated patients were assessed by flow cytometry for expression of: anergy and apoptosis inducing molecules [programmed death (PD)-1 and its ligands PD-L1 and PD-L2], inhibitory and regulatory T cell-inducing molecules [immunoglobulin-like transcript (ILT)-3 and ILT-4], interferon (IFN)-α inhibitory receptor (ILT-7) and co-stimulatory molecules (CD80, CD83, and CD86). pDC from untreated HIV-1+ patients expressed significantly lower levels of ILT-7 compared to healthy controls, while HAART-treated patients showed normal expression. pDC were also found to express moderately higher levels of PD-L1 and ILT-3 and lower levels of PD-L2 receptors in untreated patients compared to controls and HAART-treated patients. No significant changes were observed in mDC. There were no associations between the percentages and levels of expression of these molecules by pDC and viral load or CD4 T cell count. In conclusion, pDC but not mDC from HIV-1+ patients with active viraemia display higher levels of apoptosis and T regulatory-inducing molecules and may be predisposed to chronically produce IFN-α through down-regulation of ILT-7. HAART restored normal expression levels of these receptors.
AU  - Benlahrech,A
AU  - Yasmin,A
AU  - Westrop,SJ
AU  - Coleman,A
AU  - Herasimtschuk,A
AU  - Page,E
AU  - Kelleher,P
AU  - Gotch,F
AU  - Imami,N
AU  - Patterson,S
DO  - 10.1111/j.1365-2249.2012.04647.x
EP  - 221
PY  - 2012///
SN  - 0009-9104
SP  - 212
TI  - Dysregulated immunophenotypic attributes of plasmacytoid but not myeloid dendritic cells in HIV-1 infected individuals in the absence of highly active anti-retroviral therapy
T2  - Clinical and Experimental Immunology
UR  - http://dx.doi.org/10.1111/j.1365-2249.2012.04647.x
UR  - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000309601500012&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://academic.oup.com/cei/article/170/2/212/6429083
VL  - 170
ER  -
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