Publications
463 results found
Patel HC, Rosen SD, Hayward C, et al., 2016, Renal denervation in heart failure with preserved ejection fraction (RDF-PEF): a randomised controlled trial, European Journal of Heart Failure, Vol: 18, Pages: 703-712, ISSN: 1879-0844
AimHeart failure with preserved ejection fraction (HFpEF) is associated with increased sympathetic nervous system (SNS) tone. Attenuating the SNS with renal denervation (RD) might be helpful and there are no data currently in humans with HFpEF.Methods and ResultsIn this single-centre, randomised, open-controlled study we included 25 patients with HFpEF (preserved left ventricular (LV) ejection fraction, left atrial (LA) dilatation or LV hypertrophy and raised B-type natriuretic peptide (BNP) or echocardiographic assessment of filling pressures). Patients were randomised (2:1) to RD with the Symplicity™ catheter or continuing medical therapy. The primary success criterion was not met in that there were no differences between groups at 12 months for Minnesota Living with Heart Failure Questionnaire score, peak oxygen uptake (VO2) on exercise, BNP, E/e’, LA volume index or LV mass index. A greater proportion of patients improved at three months in the RD group with respect to VO2 peak (56% vs 13%, P=0.025) and E/e’ (31% vs 13%, P=0.04). Change in estimated glomerular filtration rate was comparable between groups. Two patients required plain balloon angioplasty during the RD procedure to treat renal artery wall oedema.ConclusionThis study was terminated early due to difficulties in recruitment and was underpowered to detect whether RD improved the endpoints of: quality of life, exercise function, biomarkers and left heart remodelling. The procedure was safe in patients with HFpEF though two patients did require intra-procedure renal artery dilatation.
Vassiliou VS, Patel HC, Rosen SD, et al., 2016, Left atrial dilation in patients with heart failure and preserved ejection fraction: Insights from cardiovascular magnetic resonance, International Journal of Cardiology, Vol: 210, Pages: 158-160, ISSN: 1874-1754
Mitchell FM, Prasad SK, Greil GF, et al., 2016, Cardiovascular magnetic resonance: Diagnostic utility and specific considerations in the pediatric population, World Journal of Clinical Pediatrics, Vol: 5, Pages: 1-15, ISSN: 2219-2808
Cardiovascular magnetic resonance is a non-invasive imaging modality which is emerging as important tool for the investigation and management of pediatric cardiovascular disease. In this review we describe the key technical and practical differences between scanning children and adults, and highlight some important considerations that must be taken into account for this patient population. Using case examples commonly seen in clinical practice, we discuss the important clinical applications of cardiovascular magnetic resonance, and briefly highlight key future developments in this field.
Vassiliou V, Wassilew K, Malley T, et al., 2016, Incremental benefit in correlation with histology of native T1 mapping, partition coefficient and extracellular volume fraction in patients with aortic stenosis, Journal of Cardiovascular Magnetic Resonance, Vol: 18, ISSN: 1097-6647
Ware JS, Li J, Mazaika E, et al., 2016, Shared genetic etiology of peripartum and dilated cardiomyopathies, New England Journal of Medicine, Vol: 374, Pages: 233-241, ISSN: 1533-4406
Background: Peripartum cardiomyopathy (PPCM) shares some clinical features with idiopathic dilated cardiomyopathy, a disorder caused by mutations in over 40 genes, including TTN, which encodes the sarcomere protein titin.Methods: We sequenced 43 genes, with variants that have been associated with dilated cardiomyopathy, in 172 women with peripartum cardiomyopathy. We compared the prevalence of different types of variant (nonsense, frameshift, and splicing) in these women with the prevalence of these variants in persons with dilated cardiomyopathy and population controls.Results: We identified 26 distinct rare truncating variants in eight genes in women with PPCM. The prevalence of truncating variants (26 in 172 [15%]) was significantly higher than in a reference population of 60,706 individuals (4.7%, P=1.3x10-7), but was similar to a cohort of 332 dilated cardiomyopathy cases (55 in 332 [17%], P=0.81). Two thirds of identified truncating variants were in TTN ([10%], P=2.7x10-10 versus 1.4% in reference population), almost all located in the titin A-band. Seven of the TTN truncating variants were previously reported in cases of idiopathic dilated cardiomyopathy. In a clinically well-characterized cohort of women with PPCM (n=83), the presence of TTN truncating variants correlated with lower ejection fraction at one-year follow-up (P=0.005). Conclusions: The distribution of truncating variants in a large series of women with PPCM is remarkably similar to that found in idiopathic dilated cardiomyopathy. TTN truncating variants are the most prevalent genetic predisposition of each disorder.
Vassiliou V, Wassilew K, Asimakopoulos G, et al., 2016, Histological validation of a new CMR T1-mapping-based protocol to improve accuracy for fibrosis assessment in patients with aortic stenosis, Journal of Cardiovascular Magnetic Resonance, Vol: 18, Pages: 1-3, ISSN: 1097-6647
Scott AD, Tayal U, Nielles-Vallespin S, et al., 2016, Accelerating cine DENSE using a zonal excitation, Journal of Cardiovascular Magnetic Resonance, Vol: 18, Pages: 1-3, ISSN: 1097-6647
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- Citations: 7
Vassiliou V, Anita S, Malley T, et al., 2016, Systolic T1 mapping for estimation of myocardial diffuse fibrosis, Journal of Cardiovascular Magnetic Resonance, Vol: 18, Pages: 1-2, ISSN: 1097-6647
Mathew GL, Vassiliou V, Heng EL, et al., 2016, Streamlining trigger delay estimation for T1 mapping, Journal of Cardiovascular Magnetic Resonance, Vol: 18, Pages: 1-2, ISSN: 1097-6647
Imran M, Wang L, McCrohon J, et al., 2016, Multiparametric mapping in the diagnosis and management of cardiac transplant rejection: A prospective, histologically-validated study, Journal of Cardiovascular Magnetic Resonance, Vol: 18, Pages: 1-2, ISSN: 1097-6647
Pennell DJ, Baksi AJ, Prasad SK, et al., 2015, Review of Journal of Cardiovascular Magnetic Resonance 2014, Journal of Cardiovascular Magnetic Resonance, Vol: 17, ISSN: 1532-429X
There were 102 articles published in the Journal of Cardiovascular Magnetic Resonance (JCMR) in 2014, which is a6 % decrease on the 109 articles published in 2013. The quality of the submissions continues to increase. The 2013JCMR Impact Factor (which is published in June 2014) fell to 4.72 from 5.11 for 2012 (as published in June 2013).The 2013 impact factor means that the JCMR papers that were published in 2011 and 2012 were cited on average4.72 times in 2013. The impact factor undergoes natural variation according to citation rates of papers in the 2 yearsfollowing publication, and is significantly influenced by highly cited papers such as official reports. However,the progress of the journal’s impact over the last 5 years has been impressive. Our acceptance rate is <25 %and has been falling because the number of articles being submitted has been increasing. In accordance withOpen-Access publishing, the JCMR articles go on-line as they are accepted with no collating of the articlesinto sections or special thematic issues. For this reason, the Editors have felt that it is useful once per calendar year tosummarize the papers for the readership into broad areas of interest or theme, so that areas of interest canbe reviewed in a single article in relation to each other and other recent JCMR articles. The papers are presented inbroad themes and set in context with related literature and previously published JCMR papers to guide continuity ofthought in the journal. We hope that you find the open-access system increases wider reading and citation of yourpapers, and that you will continue to send your quality papers to JCMR for publication.
Raphael CE, Vassiliou V, Alpendurada F, et al., 2015, Clinical value of cardiovascular magnetic resonance in patients with MR-conditional pacemakers., European Heart Journal- Cardiovascular Imaging, Vol: 17, Pages: 1178-1185, ISSN: 2047-2404
AIMS: Magnetic resonance (MR) conditional pacemakers are increasingly implanted into patients who may need cardiovascular MR (CMR) subsequent to device implantation. We assessed the added value of CMR for diagnosis and management in this population. METHODS AND RESULTS: CMR and pacing data from consecutive patients with MR conditional pacemakers were retrospectively reviewed. Images were acquired at 1.5 T (Siemens Magnetom Avanto). The indication for CMR and any resulting change in management was recorded. The quality of CMR was rated by an observer blinded to clinical details, and data on pacemaker and lead parameters were collected pre- and post-CMR. Seventy-two CMR scans on 69 patients performed between 2011 and 2015 were assessed. All scans were completed successfully with no significant change in lead thresholds or pacing parameters. Steady-state free precession (SSFP) cine imaging resulted in a greater frequency of non-diagnostic imaging (22 vs. 1%, P < 0.01) compared with gradient echo sequences (GRE). Right-sided pacemakers were associated with less artefact than left-sided pacemakers. Late gadolinium enhancement imaging was performed in 59 scans with only 2% of segments rated of non-diagnostic quality. The CMR data resulted in a new diagnosis in 27 (38%) of examinations; clinical management was changed in a further 18 (25%). CONCLUSIONS: CMR in patients with MR conditional pacemakers provided diagnostic or management-changing information in the majority (63%) of our cohort. The use of gradient echo cine sequences can reduce rates of non-diagnostic imaging. Right-sided device implantation may be considered in patients likely to require CMR examination.
Keegan J, Raphael CE, Parker K, et al., 2015, Validation of high temporal resolution spiral phase velocity mapping of temporal patterns of left and right coronary artery blood flow against Doppler guidewire, Journal of Cardiovascular Magnetic Resonance, Vol: 17, ISSN: 1532-429X
Background: Temporal patterns of coronary blood flow velocity can provide important information on disease state and are currently assessed invasively using a Doppler guidewire. A non-invasive alternative would be beneficial as it would allow study of a wider patient population and serial scanning. Methods: A retrospectively-gated breath-hold spiral phase velocity mapping sequence (TR 19 ms) was developed at 3 Tesla. Velocity maps were acquired in 8 proximal right and 15 proximal left coronary arteries of 18 subjects who had previously had a Doppler guidewire study at the time of coronary angiography. Cardiovascular magnetic resonance (CMR) velocity-time curves were processed semi-automatically and compared with corresponding invasive Doppler data. Results: When corrected for differences in heart rate between the two studies, CMR mean velocity through the cardiac cycle, peak systolic velocity (PSV) and peak diastolic velocity (PDV) were approximately 40 % of the peak Doppler values with a moderate - good linear relationship between the two techniques (R<sup>2</sup>: 0.57, 0.64 and 0.79 respectively). CMR values of PDV/PSV showed a strong linear relationship with Doppler values with a slope close to unity (0.89 and 0.90 for right and left arteries respectively). In individual vessels, plots of CMR velocities at all cardiac phases against corresponding Doppler velocities showed a consistent linear relationship between the two with high R<sup>2</sup> values (mean +/-SD: 0.79 +/-.13). Conclusions: High temporal resolution breath-hold spiral phase velocity mapping underestimates absolute values of coronary flow velocity but allows accurate assessment of the temporal patterns of blood flow.
Hamshere S, Arnous S, Choudhury T, et al., 2015, Randomized trial of combination cytokine and adult autologous bone marrow progenitor cell administration in patients with non-ischaemic dilated cardiomyopathy: the REGENERATE-DCM clinical trial, European Heart Journal, Vol: 36, Pages: 3061-3069, ISSN: 1522-9645
Aims The REGENERATE-DCM trial is the first phase II randomized, placebo-controlled trial aiming to assess if granulocyte colony-stimulating factor (G-CSF) administration with or without adjunctive intracoronary (IC) delivery of autologous bone marrow-derived cells (BMCs) improves global left ventricular (LV) function in patients with dilated cardiomyopathy (DCM) and significant cardiac dysfunction.Methods and results Sixty patients with DCM and left ventricular ejection fraction (LVEF) at referral of ≤45%, New York Heart Association (NYHA) classification ≥2 and no secondary cause for the cardiomyopathy were randomized equally into four groups: peripheral placebo (saline), peripheral G-CSF, peripheral G-CSF and IC serum, and peripheral G-CSF and IC BMC. All patients, except the peripheral placebo group, received 5 days of G-CSF. In the IC groups, this was followed by bone marrow harvest and IC infusion of cells or serum on Day 6. The primary endpoint was LVEF change from baseline to 3 months, determined by advanced cardiac imaging. At 3 months, peripheral G-CSF combined with IC BMC therapy was associated with a 5.37% point increase in LVEF (38.30% ± 12.97 from 32.93% ± 16.46 P = 0.0138), which was maintained to 1 year. This was associated with a decrease in NYHA classification, reduced NT-pro BNP, and improved exercise capacity and quality of life. No significant change in LVEF was seen in the remaining treatment groups.Conclusion This is the first randomized, placebo-controlled trial with a novel combination of G-CSF and IC cell therapy that demonstrates an improvement in cardiac function, symptoms, and biochemical parameters in patients with DCM.
Vassiliou V, Raphael CE, Perperoglou A, et al., 2015, Predictors of mortality in patients with aortic stenosis: the role of myocardial fibrosis, Congress of the European-Society-of-Cardiology (ESC), Publisher: OXFORD UNIV PRESS, Pages: 342-342, ISSN: 0195-668X
Raphael CE, Vassiliou V, Ali A, et al., 2015, To stent or not to stent?, Congress of the European-Society-of-Cardiology (ESC), Publisher: OXFORD UNIV PRESS, Pages: 1215-1215, ISSN: 0195-668X
Raphael CE, Hsu LY, Greve A, et al., 2015, The additive value of cardiovascular magnetic resonance first pass perfusion in diagnosis of microvascular disease in a population with chest pain and normal coronary arteries, Congress of the European-Society-of-Cardiology (ESC), Publisher: OXFORD UNIV PRESS, Pages: 244-244, ISSN: 0195-668X
Mazzarotto F, Walsh R, Buchan RJ, et al., 2015, Comprehensive sequencing of dilated cardiomyopathy genes reveals additive effects of multiple genes on disease risk and severity, Congress of the European-Society-of-Cardiology (ESC), Publisher: OXFORD UNIV PRESS, Pages: 523-523, ISSN: 0195-668X
Buyandelger B, Mansfield C, Kostin S, et al., 2015, ZBTB17 (MIZ1) Is Important for the Cardiac Stress Response and a Novel Candidate Gene for Cardiomyopathy and Heart Failure., Circulation. Cardiovascular Genetics, Vol: 8, Pages: 643-652, ISSN: 1942-3268
BACKGROUND: -Mutations in sarcomeric and cytoskeletal proteins are a major cause of hereditary cardiomyopathies, but our knowledge remains incomplete as to how the genetic defects execute their effects. METHODS AND RESULTS: -We used cysteine and glycine-rich protein 3 (CSRP3), a known cardiomyopathy gene, in a yeast two-hybrid screen and identified zinc finger and BTB domain containing protein 17 (ZBTB17) as a novel interacting partner. ZBTB17 is a transcription factor that contains the peak association signal (rs10927875) at the replicated 1p36 cardiomyopathy locus. ZBTB17 expression protected cardiac myocytes from apoptosis in vitro and in a mouse model with cardiac myocyte-specific deletion of Zbtb17, which develops cardiomyopathy and fibrosis after biomechanical stress. ZBTB17 also regulated cardiac myocyte hypertrophy in vitro and in vivo in a calcineurin-dependent manner. CONCLUSIONS: -We revealed new functions for ZBTB17 in the heart, a transcription factor which may play a role as a novel cardiomyopathy gene.
Baksi AJ, Kanaganayagam GS, Prasad SK, 2015, Arrhythmias in viral myocarditis and pericarditis., Card Electrophysiol Clin, Vol: 7, Pages: 269-281
Acute viral myocarditis and acute pericarditis are self-limiting conditions that run a benign course and that may not involve symptoms that lead to medical assessment. However, ventricular arrhythmia is frequent in viral myocarditis. Myocarditis is thought to account for a large proportion of sudden cardiac deaths in young people without prior structural heart disease. Identification of acute myocarditis either with or without pericarditis is therefore important. However, therapeutic interventions are limited and nonspecific. Identifying those at greatest risk of a life-threatening arrhythmia is critical to reducing the mortality. This review summarizes current understanding of this challenging area in which many questions remain.
Cheng H, Lu M, Hou C, et al., 2015, Comparison of cardiovascular magnetic resonance characteristics and clinical consequences in children and adolescents with isolated left ventricular non-compaction with and without late gadolinium enhancement, JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE, Vol: 17, ISSN: 1097-6647
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- Citations: 25
Prasad SK, Vassiliou VS, 2015, Rheumatoid Arthritis: Mapping the Future, JACC-CARDIOVASCULAR IMAGING, Vol: 8, Pages: 537-539, ISSN: 1936-878X
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- Citations: 2
Vassiliou V, Heng EL, Nyktari E, et al., 2015, Effect of temperature and heart rate variability on Phantom T1 maps, Journal of Cardiovascular Magnetic Resonance, Pages: 1-2, ISSN: 1097-6647
Raphael CE, Hsu LY, Greve AM, et al., 2015, Wave intensity analysis and assessment of myocardial perfusion abnormalities in patients with hypertrophic cardiomyopathy, Journal of Cardiovascular Magnetic Resonance, Vol: 17, ISSN: 1097-6647
Keegan J, Raphael CE, Simpson R, et al., 2015, Validation of high temporal resolution spiral phase velocity mapping of coronary artery blood flow against Doppler flow wire, Journal of Cardiovascular Magnetic Resonance, Pages: 1-3, ISSN: 1097-6647
McGill LA, Scott AD, Ferreira P, et al., 2015, Heterogeneity of diffusion tensor imaging measurements of fractional anisotropy and mean diffusivity in normal human hearts in vivo, Journal of Cardiovascular Magnetic Resonance, Vol: 17, ISSN: 1097-6647
Vassiliou V, Heng EL, Donovan J, et al., 2015, Longitudinal stability of gel T1 MRI Phantoms for quality assurance of T1 mapping, Journal of Cardiovascular Magnetic Resonance, Vol: 17, ISSN: 1532-429X
Raphael CE, Alpendurada F, Prasad SK, et al., 2015, The clinical value of Cardiovascular Magnetic Resonance in patients with MR-conditional pacemakers, Journal of Cardiovascular Magnetic Resonance, Pages: 1-1, ISSN: 1097-6647
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- Citations: 1
Wage R, Patel H, Smith GC, et al., 2015, The utility of magnetic resonance imaging in a trial to assess the effect of renal denervation in heart failure with preserved ejection fraction, Journal of Cardiovascular Magnetic Resonance, Pages: 1-2, ISSN: 1097-6647
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- Citations: 1
Vassiliou V, Heng EL, Sharma P, et al., 2015, Reproducibility of T1 mapping 11-heart beat MOLLI Sequence, Journal of Cardiovascular Magnetic Resonance, Pages: 1-3, ISSN: 1097-6647
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- Citations: 2
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