Imperial College London
Portrait Picture

Professor Ramesh Wigneshweraraj

Faculty of Medicine, Department of Infectious Disease

Professor of Molecular Microbiology
 
 
 
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Contact

 

+44 (0)20 7594 1867s.r.wig

 
 
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Location

 

4.40BFlowers buildingSouth Kensington Campus

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Summary

 

Publications

Publication Type
Year
to

95 results found

Bose D, Pape T, Burrows PC, Rappas M, Wigneshweraraj SR, Buck M, Zhang Xet al., 2008, Organization of an Activator-Bound RNA Polymerase Holoenzyme, MOLECULAR CELL, Vol: 32, Pages: 337-346, ISSN: 1097-2765

Journal article

Burrows PC, Wigneshweraraj S, Bose D, Joly N, Schumacher J, Rappas M, Pape T, Stockley PG, Zhang X, Buck Met al., 2008, Visualizing the organization and reorganization of transcription complexes for gene expression, BIOCHEMICAL SOCIETY TRANSACTIONS, Vol: 36, Pages: 776-779, ISSN: 0300-5127

Journal article

Wigneshweraraj S, Bose D, Burrows PC, Joly N, Schumacher J, Rappas M, Pape T, Zhang X, Stockley P, Severinov K, Buck Met al., 2008, <i>Modus operandi</i> of the bacterial RNA polymerase containing the σ<SUP>54</SUP> promoter-specificity factor, MOLECULAR MICROBIOLOGY, Vol: 68, Pages: 538-546, ISSN: 0950-382X

Journal article

Burrows PC, Wigneshweraraj SR, Buck M, 2008, Protein-DNA interactions that govern AAA<SUP>+</SUP> activator-dependent bacterial transcription initiation, JOURNAL OF MOLECULAR BIOLOGY, Vol: 375, Pages: 43-58, ISSN: 0022-2836

Journal article

Wigneshweraraj S, Burrows P, Bose D, Cannon W, Joly N, Rappas M, Schumacher J, Zhang X, Buck Met al., 2008, THE MECHANISTIC BASIS OF <i>nif</i> GENE ACTIVATION, Joint Conference of the 15th International Congress on Nitrogen Fixation/12 International Conference of the African-Association-for-Biological-Nitrogen-Fixation, Publisher: SPRINGER, Pages: 339-+, ISSN: 0924-1949

Conference paper

Joly N, Rappas M, Wigneshweraraj SR, Zhang X, Buck Met al., 2007, Coupling nucleotide hydrolysis to transcription activation performance in a bacterial enhancer binding protein, MOLECULAR MICROBIOLOGY, Vol: 66, Pages: 583-595, ISSN: 0950-382X

Journal article

Schumacher J, Joly N, Rappas M, Bradley D, Wigneshweraraj SR, Zhang X, Buck Met al., 2007, Sensor I threonine of the AAA plus ATPase transcriptional activator PspF is involved in coupling nucleoticle triphosphate hydrolysis to the restructuring of σ<SUP>54</SUP>-RNA polymerase, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 282, Pages: 9825-9833

Journal article

Dago AE, Wigneshweraraj SR, Buck M, Morett Eet al., 2007, A role for the conserved GAFTGA motif of AAA plus transcription activators in sensing promoter DNA conformation, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 282, Pages: 1087-1097

Journal article

Heilemann M, Lymperopoulos K, Wigneshweraraj SR, Buck M, Kapanidis ANet al., 2007, Studying σ<SUP>54</SUP>-dependent transcription at the single-molecule level using alternating-laser excitation (ALEX) spectroscopy, Biophotonics 2007 Conference, Publisher: SPIE-INT SOC OPTICAL ENGINEERING, ISSN: 0277-786X

Conference paper

Buck M, Bose D, Burrows P, Cannon W, Joly N, Pape T, Rappas M, Schumacher J, Wigneshweraraj S, Zhang Xet al., 2006, A second paradigm for gene activation in bacteria, BIOCHEMICAL SOCIETY TRANSACTIONS, Vol: 34, Pages: 1067-1071, ISSN: 0300-5127

Journal article

Leach RN, Gell C, Wigneshweraraj S, Buck M, Smith A, Stockley PGet al., 2006, Mapping ATP-dependent activation at σ<SUP>54</SUP> promoter, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 281, Pages: 33717-33726

Journal article

Wigneshweraraj SR, Savalia D, Severinov K, Buck Met al., 2006, Interplay between the β′ clamp and the β′ jaw domains during DNA opening by the bacterial RNA polymerase at σ<SUP>54</SUP>-dependent promoters, JOURNAL OF MOLECULAR BIOLOGY, Vol: 359, Pages: 1182-1195, ISSN: 0022-2836

Journal article

Wigneshweraraj SR, Burrows PC, Severinov K, Buck Met al., 2005, Stable DNA opening within open promoter complexes is mediated by the RNA polymerase β′-jaw domain, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 280, Pages: 36176-36184

Journal article

Rappas M, Schumacher J, Beuron F, Niwa H, Bordes P, Wigneshweraraj S, Keetch CA, Robinson CV, Buck M, Zhang XDet al., 2005, Structural insights into the activity of enhancer-binding proteins, SCIENCE, Vol: 307, Pages: 1972-1975, ISSN: 0036-8075

Journal article

Wigneshweraraj SR, Burrows PC, Bordes P, Schumacher J, Rappas M, Finn RD, Cannon WV, Zhang X, Buck Met al., 2005, The structural basis for <i>nif</i> gene activation, 14th International Nitrogen Fixation Congress, Publisher: SPRINGER, Pages: 59-63, ISSN: 0924-1949

Conference paper

Wigneshweplaraj SR, Burrows PC, Bordes P, Schumacher J, Rappas M, Finn RD, Cannon WV, Zhang X, Buck Met al., 2005, The second paradigm for activation of transcription, PROGRESS IN NUCLEIC ACID RESEARCH AND MOLECULAR BIOLOGY, VOL 79, Vol: 79, Pages: 339-369, ISSN: 0079-6603

Journal article

Burrows PC, Severinov K, Buck M, Wigneshweraraj SRet al., 2004, Reorganisation of an RNA polymerase-promoter DNA complex for DNA melting, EMBO JOURNAL, Vol: 23, Pages: 4253-4263, ISSN: 0261-4189

Journal article

Wigneshweraraj SR, Burrows PC, Nechaev S, Zenkin N, Severinov K, Buck Met al., 2004, Regulated communication between the upstream face of RNA polymerase and the β′ subunit jaw domain, EMBO JOURNAL, Vol: 23, Pages: 4264-4274, ISSN: 0261-4189

Journal article

Bordes P, Wigneshweraraj SR, Chaney M, Dago AE, Morett E, Buck Met al., 2004, Communication between Eσ<SUP>54</SUP>, promoter DNA and the conserved threonine residue in the GAFTGA motif of the PspF σ<SUP>54</SUP>-dependent activator during transcription activation, MOLECULAR MICROBIOLOGY, Vol: 54, Pages: 489-506, ISSN: 0950-382X

Journal article

Bordes P, Wigneshweraraj SR, Zhang XD, Buck Met al., 2004, σ<SUP>54</SUP>-dependent transcription activator phage shock protein F of <i>Escherichia coli</i>:: a fragmentation approach to identify sequences that contribute to self-association, BIOCHEMICAL JOURNAL, Vol: 378, Pages: 735-744, ISSN: 0264-6021

Journal article

Burrows PC, Severinov K, Ishihama A, Buck M, Wigneshweraraj SRet al., 2003, Mapping σ<SUP>54</SUP>-RNA polymerase interactions at the -24 consensus promoter element, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 278, Pages: 29728-29743, ISSN: 0021-9258

Journal article

Cannon W, Bordes P, Wigneshweraraj SR, Buck Met al., 2003, Nucleotide-dependent triggering of RNA polymerase-DNA interactions by an AAA regulator of transcription, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 278, Pages: 19815-19825, ISSN: 0021-9258

Journal article

Bordes P, Wigneshweraraj SR, Schumacher J, Zhang XD, Chaney M, Buck Met al., 2003, The ATP hydrolyzing transcription activator phage shock protein F of <i>Escherichia coli</i>:: Identifying a surface that binds σ<SUP>54</SUP>, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 100, Pages: 2278-2283, ISSN: 0027-8424

Journal article

Wigneshweraraj SR, Kuznedelov K, Severinov K, Buck Met al., 2003, Multiple roles of the RNA polymerase β subunit flap domain in σ<SUP>54</SUP>-dependent transcription, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 278, Pages: 3455-3465, ISSN: 0021-9258

Journal article

Wigneshweraraj SR, Nechaev S, Bordes P, Jones S, Cannon W, Severinov K, Buck Met al., 2003, Enhancer-dependent transcription by bacterial RNA polymerase:: The <i>β</i> subunit downstream lobe is used by σ<SUP>54</SUP> during open promoter complex formation, RNA POLYMERASES AND ASSOCIATED FACTORS, PT C, Vol: 370, Pages: 646-657, ISSN: 0076-6879

Journal article

Zhang X, Chaney M, Wigneshweraraj SR, Schumacher J, Bordes P, Cannon W, Buck Met al., 2002, Mechanochemical ATPases and transcriptional activation, MOLECULAR MICROBIOLOGY, Vol: 45, Pages: 895-903, ISSN: 0950-382X

Journal article

Wigneshweraraj SR, Nechaev S, Severinov K, Buck Met al., 2002, β subunit residues 186-433 and 436-445 are commonly used by Eσ<SUP>54</SUP> and Eσ<SUP>70</SUP> RNA polymerase for open promoter complex formation, JOURNAL OF MOLECULAR BIOLOGY, Vol: 319, Pages: 1067-1083, ISSN: 0022-2836

Journal article

Cannon W, Wigneshweraraj SR, Buck M, 2002, Interactions of regulated and deregulated forms of the σ<SUP>54</SUP> holoenzyme with heteroduplex promoter DNA, NUCLEIC ACIDS RESEARCH, Vol: 30, Pages: 886-893, ISSN: 0305-1048

Journal article

Wigneshweraraj SR, Casaz P, Buck M, 2002, Correlating protein footprinting with mutational analysis in the bacterial transcription factor σ<SUP>54</SUP> (σ<SUP>N</SUP>), NUCLEIC ACIDS RESEARCH, Vol: 30, Pages: 1016-1028, ISSN: 0305-1048

Journal article

Chaney M, Grande R, Wigneshweraraj SR, Cannon W, Casaz P, Gallegos MT, Schumacher J, Jones S, Elderkin S, Dago AE, Morett E, Buck Met al., 2001, Binding of transcriptional activators to sigma 54 in the presence of the transition state analog ADP-aluminum fluoride: insights into activator mechanochemical action, GENES & DEVELOPMENT, Vol: 15, Pages: 2282-2294, ISSN: 0890-9369

Journal article

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