Imperial College London
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Professor Ramesh Wigneshweraraj

Faculty of Medicine, Department of Infectious Disease

Professor of Molecular Microbiology
 
 
 
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Contact

 

+44 (0)20 7594 1867s.r.wig

 
 
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Location

 

4.40BFlowers buildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Brown:2014:10.1038/ncomms5115,
author = {Brown, DR and Barton, G and Pan, Z and Buck, M and Wigneshweraraj, S},
doi = {10.1038/ncomms5115},
journal = {Nature Communications},
title = {Nitrogen stress response and stringent response are coupled in Escherichia coli},
url = {http://dx.doi.org/10.1038/ncomms5115},
volume = {5},
year = {2014}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Assimilation of nitrogen is an essential process in bacteria. The nitrogen regulation stress response is an adaptive mechanism used by nitrogen-starved Escherichia coli to scavenge for alternative nitrogen sources and requires the global transcriptional regulator NtrC. In addition, nitrogen-starved E. coli cells synthesize a signal molecule, guanosine tetraphosphate (ppGpp), which serves as an effector molecule of many processes including transcription to initiate global physiological changes, collectively termed the stringent response. The regulatory mechanisms leading to elevated ppGpp levels during nutritional stresses remain elusive. Here, we show that transcription of relA, a key gene responsible for the synthesis of ppGpp, is activated by NtrC during nitrogen starvation. The results reveal that NtrC couples these two major bacterial stress responses to manage conditions of nitrogen limitation, and provide novel mechanistic insights into how a specific nutritional stress leads to elevating ppGpp levels in bacteria.
AU  - Brown,DR
AU  - Barton,G
AU  - Pan,Z
AU  - Buck,M
AU  - Wigneshweraraj,S
DO  - 10.1038/ncomms5115
PY  - 2014///
SN  - 2041-1723
TI  - Nitrogen stress response and stringent response are coupled in Escherichia coli
T2  - Nature Communications
UR  - http://dx.doi.org/10.1038/ncomms5115
UR  - http://hdl.handle.net/10044/1/23260
VL  - 5
ER  -
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