Imperial College London
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DrSaravanaRamasamy

Faculty of Medicine, National Heart & Lung Institute

Advanced Research Fellow
 
 
 
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Contact

 

+44 (0)20 3313 1182s.ramasamy Website

 
 
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Location

 

CRB 2003Hammersmith HospitalHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Romeo:2019:10.1038/s41556-019-0304-7,
author = {Romeo, SG and Alawi, KM and Rodrigues, J and Singh, A and Kusumbe, AP and Ramasamy, SK},
doi = {10.1038/s41556-019-0304-7},
journal = {Nature Cell Biology},
pages = {430--441},
title = {Endothelial proteolytic activity and interaction with non-resorbing osteoclasts mediate bone elongation},
url = {http://dx.doi.org/10.1038/s41556-019-0304-7},
volume = {21},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Growth plate cartilage contributes to the generation of a large variety of shapes and sizes of skeletal elements in the mammalian system. The removal of cartilage and how this process regulates bone shape are not well understood. Here we identify a non-bone-resorbing osteoclast subtype termed vessel-associated osteoclast (VAO). Endothelial cells at the bone/cartilage interface support VAOs through a RANKL–RANK signalling mechanism. In contrast to classical bone-associated osteoclasts, VAOs are dispensable for cartilage resorption and regulate anastomoses of type H vessels. Remarkably, proteinases including matrix metalloproteinase-9 (Mmp9) released from endothelial cells, not osteoclasts, are essential for resorbing cartilage to lead directional bone growth. Importantly, disrupting the orientation of angiogenic blood vessels by misdirecting them results in contorted bone shape. This study identifies proteolytic functions of endothelial cells in cartilage and provides a framework to explore tissue-lytic features of blood vessels in fracture healing, arthritis and cancer.
AU  - Romeo,SG
AU  - Alawi,KM
AU  - Rodrigues,J
AU  - Singh,A
AU  - Kusumbe,AP
AU  - Ramasamy,SK
DO  - 10.1038/s41556-019-0304-7
EP  - 441
PY  - 2019///
SN  - 1465-7392
SP  - 430
TI  - Endothelial proteolytic activity and interaction with non-resorbing osteoclasts mediate bone elongation
T2  - Nature Cell Biology
UR  - http://dx.doi.org/10.1038/s41556-019-0304-7
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000462859500006&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/69816
VL  - 21
ER  -
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