Imperial College London
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DrSaravanaRamasamy

Faculty of Medicine, National Heart & Lung Institute

Advanced Research Fellow
 
 
 
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Contact

 

+44 (0)20 3313 1182s.ramasamy Website

 
 
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Location

 

CRB 2003Hammersmith HospitalHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Chen:2021:10.1126/sciadv.abd7819,
author = {Chen, J and Sivan, U and Tan, SL and Lippo, L and De, Angelis J and Labella, R and Singh, A and Chatzis, A and Cheuk, S and Medhghalchi, M and Gil, J and Hollander, G and Marsden, BD and Williams, R and Ramasamy, SK and Kusumbe, AP},
doi = {10.1126/sciadv.abd7819},
journal = {Science Advances},
pages = {1--17},
title = {High-resolution 3D imaging uncovers organ-specific vascular control of tissue aging},
url = {http://dx.doi.org/10.1126/sciadv.abd7819},
volume = {7},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Blood vessels provide supportive microenvironments for maintaining tissue functions. Age-associated vascular changes and their relation to tissue aging and pathology are poorly understood. Here, we perform 3D imaging of young and aging vascular beds. Multiple organs in mice and humans demonstrate an age-dependent decline in vessel density and pericyte numbers, while highly remodeling tissues such as skin preserve the vasculature. Vascular attrition precedes the appearance of cellular hallmarks of aging such as senescence. Endothelial VEGFR2 loss-of-function mice demonstrate that vascular perturbations are sufficient to stimulate cellular changes coupled with aging. Age-associated tissue-specific molecular changes in the endothelium drive vascular loss and dictate pericyte to fibroblast differentiation. Lineage tracing of perivascular cells with inducible PDGFRβ and NG2 Cre mouse lines demonstrated that increased pericyte to fibroblast differentiation distinguishes injury-induced organ fibrosis and zymosan-induced arthritis. To spur further discoveries, we provide a freely available resource with 3D vascular and tissue maps.
AU  - Chen,J
AU  - Sivan,U
AU  - Tan,SL
AU  - Lippo,L
AU  - De,Angelis J
AU  - Labella,R
AU  - Singh,A
AU  - Chatzis,A
AU  - Cheuk,S
AU  - Medhghalchi,M
AU  - Gil,J
AU  - Hollander,G
AU  - Marsden,BD
AU  - Williams,R
AU  - Ramasamy,SK
AU  - Kusumbe,AP
DO  - 10.1126/sciadv.abd7819
EP  - 17
PY  - 2021///
SN  - 2375-2548
SP  - 1
TI  - High-resolution 3D imaging uncovers organ-specific vascular control of tissue aging
T2  - Science Advances
UR  - http://dx.doi.org/10.1126/sciadv.abd7819
UR  - https://www.ncbi.nlm.nih.gov/pubmed/33536212
UR  - http://hdl.handle.net/10044/1/86494
VL  - 7
ER  -
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