Imperial College London
Portrait Picture

DrSaravanaRamasamy

Faculty of Medicine, National Heart & Lung Institute

Advanced Research Fellow
 
 
 
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Contact

 

+44 (0)20 3313 1182s.ramasamy Website

 
 
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Location

 

CRB 2003Hammersmith HospitalHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Rodrigues:2022:10.1038/s44161-022-00139-0,
author = {Rodrigues, J and Wang, Y-F and Singh, A and Hendriks, M and Dharmalingam, G and Cohen-Solal, M and Kusumbe, A and Ramasamy, S},
doi = {10.1038/s44161-022-00139-0},
journal = {Nature Cardiovascular Research},
pages = {918--932},
title = {Estrogen enforces the integrity of blood vessels in the bone during pregnancy and menopause},
url = {http://dx.doi.org/10.1038/s44161-022-00139-0},
volume = {1},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The mammalian skeletal system shows sex differences in structure, functions, ageing and disease incidences. The role of blood vessels in physiological, regenerative and pathological bone functions indicates the requisite to understanding their sex specificity. Here, we find oestrogen regulates blood vessel physiology during pregnancy and menopause through oestrogen receptor alpha (ERa) and G-protein coupled oestrogen receptor-1 (Gper1) but not ERb-dependent signalling in mice. Oestrogen regulates BECs’ lipid use and promotes lipolysis of adipocytes and FA uptake from the microenvironment. Low oestrogen conditions skew endothelial FA metabolism to accumulate lipid peroxides (LPO), leading to vascular ageing. High ferrous ion levels in female BECs intensify LPO accumulation and accelerate the ageing process. Importantly, inhibiting LPO generation using liproxstatin-1 in aged mice significantly improved bone heath. Thus, our findings illustrate oestrogen’s effects on BECs and suggest LPO targeting could be an efficient strategy to manage blood and bone health in females.
AU  - Rodrigues,J
AU  - Wang,Y-F
AU  - Singh,A
AU  - Hendriks,M
AU  - Dharmalingam,G
AU  - Cohen-Solal,M
AU  - Kusumbe,A
AU  - Ramasamy,S
DO  - 10.1038/s44161-022-00139-0
EP  - 932
PY  - 2022///
SN  - 2731-0590
SP  - 918
TI  - Estrogen enforces the integrity of blood vessels in the bone during pregnancy and menopause
T2  - Nature Cardiovascular Research
UR  - http://dx.doi.org/10.1038/s44161-022-00139-0
UR  - https://www.nature.com/articles/s44161-022-00139-0
UR  - http://hdl.handle.net/10044/1/99772
VL  - 1
ER  -
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