Imperial College London
Portrait Picture

DrSaravanaRamasamy

Faculty of Medicine, National Heart & Lung Institute

Advanced Research Fellow
 
 
 
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Contact

 

+44 (0)20 3313 1182s.ramasamy Website

 
 
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Location

 

CRB 2003Hammersmith HospitalHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Itkin:2016:10.1038/nature17624,
author = {Itkin, T and Gur-Cohen, S and Spencer, JA and Schajnovitz, A and Ramasamy, SK and Kusumbe, AP and Ledergor, G and Jung, Y and Milo, I and Poulos, MG and Kalinkovich, A and Ludin, A and Kollet, O and Shakhar, G and Butler, JM and Rafii, S and Adams, RH and Scadden, DT and Lin, CP and Lapidot, T},
doi = {10.1038/nature17624},
journal = {Nature},
pages = {323--328},
title = {Distinct bone marrow blood vessels differentially regulate haematopoiesis},
url = {http://dx.doi.org/10.1038/nature17624},
volume = {532},
year = {2016}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Bone marrow endothelial cells (BMECs) form a network of blood vessels that regulate both leukocyte trafficking and haematopoietic stem and progenitor cell (HSPC) maintenance. However, it is not clear how BMECs balance these dual roles, and whether these events occur at the same vascular site. We found that mammalian bone marrow stem cell maintenance and leukocyte trafficking are regulated by distinct blood vessel types with different permeability properties. Less permeable arterial blood vessels maintain haematopoietic stem cells in a low reactive oxygen species (ROS) state, whereas the more permeable sinusoids promote HSPC activation and are the exclusive site for immature and mature leukocyte trafficking to and from the bone marrow. A functional consequence of high permeability of blood vessels is that exposure to blood plasma increases bone marrow HSPC ROS levels, augmenting their migration and differentiation, while compromising their long-term repopulation and survival. These findings may have relevance for clinical haematopoietic stem cell transplantation and mobilization protocols.
AU  - Itkin,T
AU  - Gur-Cohen,S
AU  - Spencer,JA
AU  - Schajnovitz,A
AU  - Ramasamy,SK
AU  - Kusumbe,AP
AU  - Ledergor,G
AU  - Jung,Y
AU  - Milo,I
AU  - Poulos,MG
AU  - Kalinkovich,A
AU  - Ludin,A
AU  - Kollet,O
AU  - Shakhar,G
AU  - Butler,JM
AU  - Rafii,S
AU  - Adams,RH
AU  - Scadden,DT
AU  - Lin,CP
AU  - Lapidot,T
DO  - 10.1038/nature17624
EP  - 328
PY  - 2016///
SN  - 0028-0836
SP  - 323
TI  - Distinct bone marrow blood vessels differentially regulate haematopoiesis
T2  - Nature
UR  - http://dx.doi.org/10.1038/nature17624
UR  - http://www.ncbi.nlm.nih.gov/pubmed/27074509
UR  - https://www.nature.com/articles/nature17624
VL  - 532
ER  -
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