Imperial College London
Portrait Picture

DrSaravanaRamasamy

Faculty of Medicine, National Heart & Lung Institute

Advanced Research Fellow
 
 
 
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Contact

 

+44 (0)20 3313 1182s.ramasamy Website

 
 
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Location

 

CRB 2003Hammersmith HospitalHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Kusumbe:2014:10.1038/nature13145,
author = {Kusumbe, AP and Ramasamy, SK and Adams, RH},
doi = {10.1038/nature13145},
journal = {Nature},
pages = {323--328},
title = {Coupling of angiogenesis and osteogenesis by a specific vessel subtype in bone},
url = {http://dx.doi.org/10.1038/nature13145},
volume = {507},
year = {2014}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The mammalian skeletal system harbours a hierarchical system of mesenchymal stem cells, osteoprogenitors and osteoblasts sustaining lifelong bone formation. Osteogenesis is indispensable for the homeostatic renewal of bone as well as regenerative fracture healing, but these processes frequently decline in ageing organisms, leading to loss of bone mass and increased fracture incidence. Evidence indicates that the growth of blood vessels in bone and osteogenesis are coupled, but relatively little is known about the underlying cellular and molecular mechanisms. Here we identify a new capillary subtype in the murine skeletal system with distinct morphological, molecular and functional properties. These vessels are found in specific locations, mediate growth of the bone vasculature, generate distinct metabolic and molecular microenvironments, maintain perivascular osteoprogenitors and couple angiogenesis to osteogenesis. The abundance of these vessels and associated osteoprogenitors was strongly reduced in bone from aged animals, and pharmacological reversal of this decline allowed the restoration of bone mass.
AU  - Kusumbe,AP
AU  - Ramasamy,SK
AU  - Adams,RH
DO  - 10.1038/nature13145
EP  - 328
PY  - 2014///
SN  - 0028-0836
SP  - 323
TI  - Coupling of angiogenesis and osteogenesis by a specific vessel subtype in bone
T2  - Nature
UR  - http://dx.doi.org/10.1038/nature13145
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000333029000026&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://www.nature.com/articles/nature13145
VL  - 507
ER  -
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