Publications
79 results found
Bo C, Williams A, Rankin S, et al., 2014, Integrated experimental platforms to study blast injuries: a bottom-up approach, 18th Joint Int Conf of the APS Topical-Grp on Shock Compress of Condensed Matter / 24th Int Conf of the Int-Assoc-for-the-Advancement-of-High-Pressure-Sci-and-Technol, Publisher: IOP PUBLISHING LTD, ISSN: 1742-6588
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- Citations: 4
Byrne AJ, Jones CP, Gowers K, et al., 2013, Lung Macrophages Contribute to House Dust Mite Driven Airway Remodeling via HIF-1α, PLOS ONE, Vol: 8, ISSN: 1932-6203
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- Citations: 26
Strydom N, Lo Celso C, Rankin SM, 2013, Dynamic changes in neutrophil expression of chemokine receptors with aging and disease, EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, Vol: 43, Pages: 13-14, ISSN: 0014-2972
Rankin SM, Martin C, Burdon PC, et al., 2013, Bone marrow - birth place and grave yard for neutrophils, EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, Vol: 43, Pages: 12-12, ISSN: 0014-2972
Strydom N, Rankin SM, 2013, Regulation of Circulating Neutrophil Numbers under Homeostasis and in Disease, JOURNAL OF INNATE IMMUNITY, Vol: 5, Pages: 304-314, ISSN: 1662-811X
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- Citations: 97
Pitchford SC, Lodie T, Rankin SM, 2012, VEGFR1 stimulates a CXCR4-dependent translocation of megakaryocytes to the vascular niche, enhancing platelet production in mice, BLOOD, Vol: 120, Pages: 2787-2795, ISSN: 0006-4971
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- Citations: 48
Rankin SM, 2012, Chemokines and adult bone marrow stem cells, IMMUNOLOGY LETTERS, Vol: 145, Pages: 47-54, ISSN: 0165-2478
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- Citations: 45
Rankin S, 2012, Mesenchymal stem cells, THORAX, Vol: 67, Pages: 565-566, ISSN: 0040-6376
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- Citations: 16
Singh RK, Liao W, Tracey-White D, et al., 2012, Rab27a-mediated protease release regulates neutrophil recruitment by allowing uropod detachment, JOURNAL OF CELL SCIENCE, Vol: 125, Pages: 1652-1656, ISSN: 0021-9533
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- Citations: 16
Dalli J, Jones CP, Cavalcanti DM, et al., 2012, Annexin A1 regulates neutrophil clearance by macrophages in the mouse bone marrow, FASEB JOURNAL, Vol: 26, Pages: 387-396, ISSN: 0892-6638
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- Citations: 62
Bo C, Balzer J, Hahnel M, et al., 2012, CELLULAR CHARACTERIZATION OF COMPRESSION-INDUCEDDAMAGE IN LIVE BIOLOGICAL SAMPLES, 7th Biennial Conference of the American-Physical-Society-Topical-Group on Shock Compression of Condensed Matter, Publisher: AMER INST PHYSICS, ISSN: 0094-243X
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- Citations: 3
Pitchford SC, Rankin SM, 2012, Combinatorial stem cell mobilization in animal models., Methods Mol Biol, Vol: 904, Pages: 139-154
It has long been recognized that single therapies, such as G-CSF, have a limited capacity to mobilize hematopoietic progenitor cells from the bone marrow. As a consequence in ∼20% of patients insufficient numbers of HPCs are mobilized to perform a bone marrow transplant. Recent studies have shown synergistic mobilization of HPCs when G-CSF pretreatment is combined with acute administration of a CXCR4 antagonist suggesting that combinatorial therapies may have therapeutic potential. In addition to HPCs, endothelial progenitor cells (EPCs) and mesenchymal stem cells (MSCs) reside in the bone marrow. These progenitor cells contribute to tissue regeneration and there is currently much interest in identifying the factors and mechanisms that regulate their mobilization. We describe a methodology for an in situ perfusion system of the mouse hind limb that permits direct quantification of stem and progenitor cell egress from the bone marrow. Progenitor cells are quantified by colony forming assays and immunohistochemistry. A strength of the methodology described is the ability to simultaneously quantify the mobilization of HPCs, EPCs and MSCs. Using this system we have shown that it is possible to achieve differential mobilization of these stem cell subsets using discrete combination therapies. Identification of such novel pharmacological regimens that stimulate the selective mobilization of EPCs and MSCs might be exploited in the future for tissue regeneration.
Rankin SM, 2012, Potential Use of CXCR4 Antagonists to Mobilize Endothelial and Mesenchymal Stem Cells, NOVEL DEVELOPMENTS IN STEM CELL MOBILIZATION: FOCUS ON CXCR4, Editors: Fruehauf, Zeller, Calandra, Publisher: SPRINGER, Pages: 423-437, ISBN: 978-1-4614-1959-4
Jones CP, Rankin SM, 2011, Bone Marrow-Derived Stem Cells and Respiratory Disease, CHEST, Vol: 140, Pages: 205-211, ISSN: 0012-3692
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- Citations: 37
Summers C, Rankin SM, Condliffe AM, et al., 2010, Neutrophil kinetics in health and disease, TRENDS IN IMMUNOLOGY, Vol: 31, Pages: 318-324, ISSN: 1471-4906
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- Citations: 715
Rankin SM, 2010, The bone marrow: a site of neutrophil clearance, JOURNAL OF LEUKOCYTE BIOLOGY, Vol: 88, Pages: 241-251, ISSN: 0741-5400
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- Citations: 113
Dalli J, Cavalcanti DM, Farksy SH, et al., 2010, Abnormalities in annexin a1 null bone marrow cells: evidence for failure of clearance of apoptotic neutrophils, EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, Vol: 40, Pages: 49-49, ISSN: 0014-2972
Watson AR, Pitchford SC, Reynolds LE, et al., 2010, Deficiency of bone marrow β3-integrin enhances non-functional neovascularization, JOURNAL OF PATHOLOGY, Vol: 220, Pages: 435-445, ISSN: 0022-3417
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- Citations: 15
Pitchford SC, Hahnel MJ, Jones CP, et al., 2010, Troubleshooting: Quantification of mobilization of progenitor cell subsets from bone marrow <i>in vivo</i>, JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS, Vol: 61, Pages: 113-121, ISSN: 1056-8719
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- Citations: 13
Babu P, North SJ, Jang-Lee J, et al., 2009, Structural characterisation of neutrophil glycans by ultra sensitive mass spectrometric glycomics methodology, GLYCOCONJUGATE JOURNAL, Vol: 26, Pages: 975-986, ISSN: 0282-0080
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- Citations: 60
Rankin SM, Lloyd CM, Pitchford SC, et al., 2009, CXCR2 mediates the recruitment of endothelial progenitor cells during allergic airways remodeling, Stem cells, Vol: 12, Pages: 3074-3081
Pitchford SC, Furze RC, Jones CP, et al., 2009, Differential Mobilization of Subsets of Progenitor Cells from the Bone Marrow, Cell Stem Cell, Vol: 4, Pages: 62-72, ISSN: 1934-5909
Williams TJ, Rankin SM, 2009, Chemokines and Phagocyte Trafficking, PHAGOCYTE-PATHOGEN INTERACTIONS: MACROPHAGES AND THE HOST RESPONSE TO INFECTION, Editors: Russell, Gordon, Publisher: AMER SOC MICROBIOLOGY, Pages: 93-106, ISBN: 978-1-55581-401-4
Furze RC, Rankin SM, 2008, Neutrophil mobilization and clearance in the bone marrow, IMMUNOLOGY, Vol: 125, Pages: 281-288, ISSN: 0019-2805
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- Citations: 298
Martin AP, Rankin S, Pitchford S, et al., 2008, Increased Expression of CCL2 in Insulin-Producing Cells of Transgenic Mice Promotes Mobilization of Myeloid Cells From the Bone Marrow, Marked Insulitis, and Diabetes, DIABETES, Vol: 57, Pages: 3025-3033, ISSN: 0012-1797
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- Citations: 82
Furze RC, Rankin SM, 2008, The role of the bone marrow in neutrophil clearance under homeostatic conditions in the mouse, FASEB JOURNAL, Vol: 22, Pages: 3111-3119, ISSN: 0892-6638
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- Citations: 142
Burdon PCE, Martin C, Rankin SM, 2008, Migration across the sinusoidal endothelium regulates neutrophil mobilization in response to ELR plus CXC chemokines, BRITISH JOURNAL OF HAEMATOLOGY, Vol: 142, Pages: 100-108, ISSN: 0007-1048
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- Citations: 42
Rankin SM, 2008, Impact of bone marrow on respiratory disease, CURRENT OPINION IN PHARMACOLOGY, Vol: 8, Pages: 236-241, ISSN: 1471-4892
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- Citations: 15
Rankin SM, 2007, “Combination therapy for the selective mobilization of mesenchymal stem cells and endothelial progenitor cells” filed through INNOVATIONS – Dec 2007 P37695GB
Wengner AM, Pitchford SC, Furze RC, et al., 2007, The co-ordinated action of G-CSF and ELR+CXC chemokines in neutrophil mobilisation during acute inflammation, Blood
In this study we have identified a unique combinatorial effect of the chemokines KC/MIP-2 and the cytokine G-CSF with respect to the rapid mobilisation of neutrophils from the bone marrow in a model of acute peritonitis. 2h following an intraperitoneal injection of thioglycollate there was a 4.5 fold increase in blood neutrophil numbers which was inhibited by 84% and 72% prior administration of blocking mAbs against either the chemokines KC/ MIP-2 or G-CSF, respectively. An i.p. injection of G-CSF acted remotely to stimulate neutrophil mobilisation, but did not elicit recruitment into the peritoneum. Further, in vitro G -CSF was neither chemotactic nor chemokinetic for murine neutrophils and had no priming effect on chemotaxis stimulated by chemokines. Here we show that, in vitro and in vivo, G-CSF induces neutrophil mobilisation by disrupting their SDF-1alpha-mediated retention in the bone marrow. Using an in situ perfusion system of the mouse femoral bone marrow to directly assess mobilisation, KC and G-CSF mobilised 6.8 x 106 and 5.4 x 106 neutrophils respectively, while the infusion of KC and G-CSF together mobilised 19.5 x 106 neutrophils, indicating that these factors act co-operatively with respect to neutrophil mobilisation.
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