Imperial College London
Alternate

ProfessorSaraRankin

Faculty of Medicine, National Heart & Lung Institute

Professor of Leukocyte and Stem Cell Biology
 
 
 
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Contact

 

+44 (0)20 7594 3172s.rankin

 
 
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Assistant

 

Ms Georgina Moss +44 (0)20 7594 2151

 
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Location

 

Office no. 351Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Fellous:2020:10.1038/s41536-020-0088-1,
author = {Fellous, TG and Redpath, AN and Fleischer, MM and Gandhi, S and Hartner, SE and Newton, MD and François, M and Wong, S-P and Gowers, KHC and Fahs, AM and Possley, DR and Bonnet, D and Urquhart, P and Nicolaou, A and Baker, KC and Rankin, SM},
doi = {10.1038/s41536-020-0088-1},
journal = {NPJ Regen Med},
title = {Pharmacological tools to mobilise mesenchymal stromal cells into the blood promote bone formation after surgery.},
url = {http://dx.doi.org/10.1038/s41536-020-0088-1},
volume = {5},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Therapeutic approaches requiring the intravenous injection of autologous or allogeneic mesenchymal stromal cells (MSCs) are currently being evaluated for treatment of a range of diseases, including orthopaedic injuries. An alternative approach would be to mobilise endogenous MSCs into the blood, thereby reducing costs and obviating regulatory and technical hurdles associated with development of cell therapies. However, pharmacological tools for MSC mobilisation are currently lacking. Here we show that β3 adrenergic agonists (β3AR) in combination with a CXCR4 antagonist, AMD3100/Plerixafor, can mobilise MSCs into the blood in mice and rats. Mechanistically we show that reversal of the CXCL12 gradient across the bone marrow endothelium and local generation of endocannabinoids may both play a role in this process. Using a spine fusion model we provide evidence that this pharmacological strategy for MSC mobilisation enhances bone formation.
AU  - Fellous,TG
AU  - Redpath,AN
AU  - Fleischer,MM
AU  - Gandhi,S
AU  - Hartner,SE
AU  - Newton,MD
AU  - François,M
AU  - Wong,S-P
AU  - Gowers,KHC
AU  - Fahs,AM
AU  - Possley,DR
AU  - Bonnet,D
AU  - Urquhart,P
AU  - Nicolaou,A
AU  - Baker,KC
AU  - Rankin,SM
DO  - 10.1038/s41536-020-0088-1
PY  - 2020///
TI  - Pharmacological tools to mobilise mesenchymal stromal cells into the blood promote bone formation after surgery.
T2  - NPJ Regen Med
UR  - http://dx.doi.org/10.1038/s41536-020-0088-1
UR  - https://www.ncbi.nlm.nih.gov/pubmed/33574289
VL  - 5
ER  -
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