Imperial College London
Alternate

ProfessorSaraRankin

Faculty of Medicine, National Heart & Lung Institute

Professor of Leukocyte and Stem Cell Biology
 
 
 
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Contact

 

+44 (0)20 7594 3172s.rankin

 
 
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Assistant

 

Ms Georgina Moss +44 (0)20 7594 2151

 
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Location

 

Office no. 351Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Todorova:2023:10.1242/dmm.049630,
author = {Todorova, VB and Baxan, N and Delahaye, M and Harding, SE and Rankin, SM},
doi = {10.1242/dmm.049630},
journal = {Disease Models and Mechanisms},
pages = {1--28},
title = {Drug-based mobilisation of mesenchymal stem/stromal cells improves cardiac function post myocardial infarction},
url = {http://dx.doi.org/10.1242/dmm.049630},
volume = {16},
year = {2023}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - There is an unmet need for treatments that prevent the progressive cardiac dysfunction following myocardial infarction. Mesenchymal stem/stromal cells (MSCs) are under investigation for cardiac repair; however, culture expansion prior to transplantation is hindering their homing and reparative abilities. Pharmacological mobilisation could be an alternative to MSC transplantation. Here, we report that endogenous MSCs mobilise into the circulation at day 5 post myocardial infarction in male Lewis rats. This mobilisation can be significantly increased by using a combination of the FDA-approved drugs mirabegron (β3-adrenoceptor agonist) and AMD3100 (CXCR4 antagonist). Blinded cardiac magnetic resonance imaging analysis showed the treated group to have increased left ventricular ejection fraction and decreased end systolic volume at 5 weeks post myocardial infarction. The mobilised group had a significant decrease in plasma IL-6 and TNF-α levels, a decrease in interstitial fibrosis, and an increase in the border zone blood vessel density. Conditioned medium from blood-derived MSCs supported angiogenesis in vitro, as shown by tube formation and wound healing assays. Our data suggest a novel pharmacological strategy that enhances myocardial infarction-induced MSC mobilisation and improves cardiac function after myocardial infarction.
AU  - Todorova,VB
AU  - Baxan,N
AU  - Delahaye,M
AU  - Harding,SE
AU  - Rankin,SM
DO  - 10.1242/dmm.049630
EP  - 28
PY  - 2023///
SN  - 1754-8403
SP  - 1
TI  - Drug-based mobilisation of mesenchymal stem/stromal cells improves cardiac function post myocardial infarction
T2  - Disease Models and Mechanisms
UR  - http://dx.doi.org/10.1242/dmm.049630
UR  - https://www.ncbi.nlm.nih.gov/pubmed/36263604
UR  - http://hdl.handle.net/10044/1/101003
VL  - 16
ER  -
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