Imperial College London
Alternate

Steven Riley

Faculty of Medicine, School of Public Health

Professor of Infectious Disease Dynamics
 
 
 
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Contact

 

+44 (0)20 7594 2452s.riley

 
 
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Location

 

UG8Medical SchoolSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@unpublished{Elliott:2021,
author = {Elliott, J and Whitaker, M and Bodinier, B and Riley, S and Ward, H and Cooke, G and Darzi, A and Chadeau-Hyam, M and Elliott, P},
title = {Symptom reporting in over 1 million people: community detection of COVID-19},
url = {http://hdl.handle.net/10044/1/85969},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - UNPB
AB  - Control of the SARS-CoV-2 epidemic requires rapid identification and isolation of infectedindividuals and their contacts. Community testing in England (Pillar 2) by polymerase chainreaction (PCR) is reserved for those reporting at least one of four ‘classic’ COVID-19 symptoms(loss or change of sense of smell, loss or change of sense of taste, fever, new continuous cough). 1Detection of positive cases in the community might be improved by including additionalsymptoms and their combinations. We used data from the REal-time Assessment of CommunityTransmission-1 (REACT-1) study to investigate symptom profiles for PCR positivity at differentages. Among rounds 2–7 (June to December 2020), an age-stratified, variable selection approachstably selected chills (all ages), headache (5–17 years), appetite loss (18–54 and 55+ years) andmuscle aches (18–54 years) as jointly and positively predictive of PCR positivity together withthe classic four symptoms. Between round 7 (November to December 2020) and round 8(January 2021) when new variant B.1.1.7 predominated, only loss or change of sense of smell(more predictive in round 7) and (borderline) new persistent cough (more predictive in round 8)differed between cases. At any level of PCR testing, triage based on the symptoms identifiedhere would result in more cases detected than the current approach .
AU  - Elliott,J
AU  - Whitaker,M
AU  - Bodinier,B
AU  - Riley,S
AU  - Ward,H
AU  - Cooke,G
AU  - Darzi,A
AU  - Chadeau-Hyam,M
AU  - Elliott,P
PY  - 2021///
TI  - Symptom reporting in over 1 million people: community detection of COVID-19
UR  - http://hdl.handle.net/10044/1/85969
ER  -
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