Imperial College London
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DrSophieRutschmann

Faculty of Medicine, Department of Immunology and Inflammation

Reader in Immunology
 
 
 
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Contact

 

s.rutschmann Website

 
 
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Location

 

9N4bHammersmith HospitalHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Janssen:2006:10.1016/j.immuni.2006.03.024,
author = {Janssen, E and Tabeta, K and Barnes, MJ and Rutschmann, S and McBride, S and Bahjat, KS and Schoenberger, SP and Theofilopoulos, AN and Beutler, B and Hoebe, K},
doi = {10.1016/j.immuni.2006.03.024},
journal = {Immunity},
pages = {787--799},
title = {Efficient T cell activation via a Toll-Interleukin 1 Receptor-independent pathway.},
url = {http://dx.doi.org/10.1016/j.immuni.2006.03.024},
volume = {24},
year = {2006}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Here, we describe a previously unrecognized pathway for activation of antigen-specific adaptive immune responses that was independent of Toll-Interleukin 1 Receptor signaling and directed toward detection of antigens expressed by apoptotic cells. This pathway is represented within Flt-3 Ligand-derived dendritic cells (DCs) that represent immature lymphoid DCs, but not within GM-CSF-treated bone marrow-derived dendritic cells. Exposure of these DCs to apoptotic cells resulted in production of type I interferon and favored the development of cytotoxic T cell responses. The N-Ethyl-N-Nitrosourea-induced germline mutation 3d (Unc3b1(3d/3d)) abolished both MHC class I and II responses elicited by this pathway, whereas a null allele of Cd36 selectively abolished class II responses. We propose that this mode of adaptive immune activation evolved to permit the sensitive detection of intracellular microbial infections, particularly viral infections, which frequently induce apoptotic cell death, but may also be important in transplantation, autoimmunity, and vaccine development.
AU  - Janssen,E
AU  - Tabeta,K
AU  - Barnes,MJ
AU  - Rutschmann,S
AU  - McBride,S
AU  - Bahjat,KS
AU  - Schoenberger,SP
AU  - Theofilopoulos,AN
AU  - Beutler,B
AU  - Hoebe,K
DO  - 10.1016/j.immuni.2006.03.024
EP  - 799
PY  - 2006///
SN  - 1074-7613
SP  - 787
TI  - Efficient T cell activation via a Toll-Interleukin 1 Receptor-independent pathway.
T2  - Immunity
UR  - http://dx.doi.org/10.1016/j.immuni.2006.03.024
UR  - https://www.ncbi.nlm.nih.gov/pubmed/16782034
VL  - 24
ER  -
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