Imperial College London
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DrSophieRutschmann

Faculty of Medicine, Department of Immunology and Inflammation

Reader in Immunology
 
 
 
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Contact

 

s.rutschmann Website

 
 
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Location

 

9N4bHammersmith HospitalHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Georgel:2005:10.1128/IAI.73.8.4512-4521.2005,
author = {Georgel, P and Crozat, K and Lauth, X and Makrantonaki, E and Seltmann, H and Sovath, S and Hoebe, K and Du, X and Rutschmann, S and Jiang, Z and Bigby, T and Nizet, V and Zouboulis, CC and Beutler, B},
doi = {10.1128/IAI.73.8.4512-4521.2005},
journal = {Infect Immun},
pages = {4512--4521},
title = {A toll-like receptor 2-responsive lipid effector pathway protects mammals against skin infections with gram-positive bacteria.},
url = {http://dx.doi.org/10.1128/IAI.73.8.4512-4521.2005},
volume = {73},
year = {2005}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - flake (flk), an N-ethyl-N-nitrosourea-induced recessive germ line mutation of C57BL/6 mice, impairs the clearance of skin infections by Streptococcus pyogenes and Staphylococcus aureus, gram-positive pathogens that elicit innate immune responses by activating Toll-like receptor 2 (TLR2). Positional cloning and sequencing revealed that flk is a novel allele of the stearoyl coenzyme A desaturase 1 gene (Scd1). flake homozygotes show reduced sebum production and are unable to synthesize the monounsaturated fatty acids (MUFA) palmitoleate (C(16:1)) and oleate (C(18:1)), both of which are bactericidal against gram-positive (but not gram-negative) organisms in vitro. However, intradermal MUFA administration to S. aureus-infected mice partially rescues the flake phenotype, which indicates that an additional component of the sebum may be required to improve bacterial clearance. In normal mice, transcription of Scd1-a gene with numerous NF-kappaB elements in its promoter--is strongly and specifically induced by TLR2 signaling. Similarly, the SCD1 gene is induced by TLR2 signaling in a human sebocyte cell line. These observations reveal the existence of a regulated, lipid-based antimicrobial effector pathway in mammals and suggest new approaches to the treatment or prevention of infections with gram-positive bacteria.
AU  - Georgel,P
AU  - Crozat,K
AU  - Lauth,X
AU  - Makrantonaki,E
AU  - Seltmann,H
AU  - Sovath,S
AU  - Hoebe,K
AU  - Du,X
AU  - Rutschmann,S
AU  - Jiang,Z
AU  - Bigby,T
AU  - Nizet,V
AU  - Zouboulis,CC
AU  - Beutler,B
DO  - 10.1128/IAI.73.8.4512-4521.2005
EP  - 4521
PY  - 2005///
SN  - 0019-9567
SP  - 4512
TI  - A toll-like receptor 2-responsive lipid effector pathway protects mammals against skin infections with gram-positive bacteria.
T2  - Infect Immun
UR  - http://dx.doi.org/10.1128/IAI.73.8.4512-4521.2005
UR  - https://www.ncbi.nlm.nih.gov/pubmed/16040962
VL  - 73
ER  -
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