Imperial College London
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DrSophieRutschmann

Faculty of Medicine, Department of Immunology and Inflammation

Reader in Immunology
 
 
 
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Contact

 

s.rutschmann Website

 
 
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Location

 

9N4bHammersmith HospitalHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Popkin:2011:10.1016/j.chom.2011.02.006,
author = {Popkin, DL and Teijaro, JR and Sullivan, BM and Urata, S and Rutschmann, S and de, la Torre JC and Kunz, S and Beutler, B and Oldstone, M},
doi = {10.1016/j.chom.2011.02.006},
journal = {Cell Host Microbe},
pages = {212--222},
title = {Hypomorphic mutation in the site-1 protease Mbtps1 endows resistance to persistent viral infection in a cell-specific manner.},
url = {http://dx.doi.org/10.1016/j.chom.2011.02.006},
volume = {9},
year = {2011}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The prototypic arenavirus lymphocytic choriomeningitis virus (LCMV), which naturally persists in rodents, represents a model for HIV, HBV, and HCV. Cleavage of the viral glycoprotein precursor by membrane-bound transcription factor peptidase, site 1 (Mbtps1 or site-1 protease), is crucial for the life cycle of arenaviruses and therefore represents a potential target for therapy. Recently, we reported a viable hypomorphic allele of Mbtps1 (woodrat) encoding a protease with diminished enzymatic activity. Using the woodrat allele, we examine the role of Mbtps1 during persistent LCMV infection. Surprisingly, Mbtps1 inhibition limits persistent but not acute viral infection and is associated with an organ/cell type-specific decrease in viral titers. Analysis of bone marrow-derived dendritic cells from woodrat mice supports their specific role in resolving persistent viral infection. These results support in vivo targeting of Mbtps1 in the treatment of arenavirus infections and demonstrate a critical role for dendritic cells in persistent viral infections.
AU  - Popkin,DL
AU  - Teijaro,JR
AU  - Sullivan,BM
AU  - Urata,S
AU  - Rutschmann,S
AU  - de,la Torre JC
AU  - Kunz,S
AU  - Beutler,B
AU  - Oldstone,M
DO  - 10.1016/j.chom.2011.02.006
EP  - 222
PY  - 2011///
SP  - 212
TI  - Hypomorphic mutation in the site-1 protease Mbtps1 endows resistance to persistent viral infection in a cell-specific manner.
T2  - Cell Host Microbe
UR  - http://dx.doi.org/10.1016/j.chom.2011.02.006
UR  - https://www.ncbi.nlm.nih.gov/pubmed/21402360
VL  - 9
ER  -
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