Imperial College London
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DrSophieRutschmann

Faculty of Medicine, Department of Immunology and Inflammation

Reader in Immunology
 
 
 
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Contact

 

s.rutschmann Website

 
 
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Location

 

9N4bHammersmith HospitalHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Rutschmann:2006:10.4049/jimmunol.176.12.7525,
author = {Rutschmann, S and Hoebe, K and Zalevsky, J and Du, X and Mann, N and Dahiyat, BI and Steed, P and Beutler, B},
doi = {10.4049/jimmunol.176.12.7525},
journal = {J Immunol},
pages = {7525--7532},
title = {PanR1, a dominant negative missense allele of the gene encoding TNF-alpha (Tnf), does not impair lymphoid development.},
url = {http://dx.doi.org/10.4049/jimmunol.176.12.7525},
volume = {176},
year = {2006}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - A dominant hypomorphic allele of Tnf, PanR1, was identified in a population of G(1) mice born to N-ethyl-N-nitrosourea-mutagenized sires. Macrophages from homozygotes produced no detectable TNF bioactivity, although normal quantities of immunoreactive TNF were secreted. The phenotype was confined to a critical region on mouse chromosome 17, and then ascribed to a C-->A transversion at position 3480 of the Tnf gene, corresponding to the amino acid substitution P138T. As a result of subunit exchange, the protein exerts a dominant-negative effect on normal TNF trimers, interfering with the trimer/receptor interaction. Homozygotes are highly susceptible to infection by Listeria monocytogenes, confirming the essential role of TNF in innate immune defense. However, PanR1 mutant mice show normal architecture of the spleen and Peyer's patches, suggesting that TNF is not essential for the formation of these lymphoid structures.
AU  - Rutschmann,S
AU  - Hoebe,K
AU  - Zalevsky,J
AU  - Du,X
AU  - Mann,N
AU  - Dahiyat,BI
AU  - Steed,P
AU  - Beutler,B
DO  - 10.4049/jimmunol.176.12.7525
EP  - 7532
PY  - 2006///
SN  - 0022-1767
SP  - 7525
TI  - PanR1, a dominant negative missense allele of the gene encoding TNF-alpha (Tnf), does not impair lymphoid development.
T2  - J Immunol
UR  - http://dx.doi.org/10.4049/jimmunol.176.12.7525
UR  - https://www.ncbi.nlm.nih.gov/pubmed/16751399
VL  - 176
ER  -
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