Imperial College London
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DrSophieRutschmann

Faculty of Medicine, Department of Immunology and Inflammation

Reader in Immunology
 
 
 
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Contact

 

s.rutschmann Website

 
 
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Location

 

9N4bHammersmith HospitalHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Okoye:2015:10.1126/science.aaa7516,
author = {Okoye, I and Wang, L and Pallmer, K and Richter, K and Ichimura, T and Haas, R and Crouse, J and Choi, O and Heathcote, D and Lovo, E and Mauro, C and Abdi, R and Oxenius, A and Rutschmann, S and Ashton-Rickardt, PG},
doi = {10.1126/science.aaa7516},
journal = {Science},
pages = {995--1001},
title = {The protein LEM promotes CD8(+) T cell immunity through effects on mitochondrial respiration},
url = {http://dx.doi.org/10.1126/science.aaa7516},
volume = {348},
year = {2015}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Protective CD8+ T cell–mediated immunity requires a massive expansion in cell number and the development of long-lived memory cells. Using forward genetics in mice, we identified an orphan protein named lymphocyte expansion molecule (LEM) that promoted antigen-dependent CD8+ T cell proliferation, effector function, and memory cell generation in response to infection with lymphocytic choriomeningitis virus. Generation of LEM-deficient mice confirmed these results. Through interaction with CR6 interacting factor (CRIF1), LEM controlled the levels of oxidative phosphorylation (OXPHOS) complexes and respiration, resulting in the production of pro-proliferative mitochondrial reactive oxygen species (mROS). LEM provides a link between immune activation and the expansion of protective CD8+ T cells driven by OXPHOS and represents a pathway for the restoration of long-term protective immunity based on metabolically modified cytotoxic CD8+ T cells.
AU  - Okoye,I
AU  - Wang,L
AU  - Pallmer,K
AU  - Richter,K
AU  - Ichimura,T
AU  - Haas,R
AU  - Crouse,J
AU  - Choi,O
AU  - Heathcote,D
AU  - Lovo,E
AU  - Mauro,C
AU  - Abdi,R
AU  - Oxenius,A
AU  - Rutschmann,S
AU  - Ashton-Rickardt,PG
DO  - 10.1126/science.aaa7516
EP  - 1001
PY  - 2015///
SN  - 0036-8075
SP  - 995
TI  - The protein LEM promotes CD8(+) T cell immunity through effects on mitochondrial respiration
T2  - Science
UR  - http://dx.doi.org/10.1126/science.aaa7516
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000355276600039&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/34339
VL  - 348
ER  -
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