Summary
I am a Research Associate in Malaria Genomic Epidemiology based in the MRC Centre for Global Infectious Disease Analysis at Imperial College London. My work involves the development of the SIMPLEGEN pipeline to simulate malaria population genetic structure under varying epidemiological conditions. This modelling tool will allow users (researchers and national malaria control programme officers) to explore the "power" of genomic sampling designs in silico to help inform malaria genomic surveillance best practices.
I am a genomic epidemiologist by training with expertise in population genetics, bioinformatics, and epidemiology. I’m interested in combining these approaches to population‐based studies of infectious diseases, particularly malaria and other vector-borne diseases, and more recently COVID‐19. My work has involved international collaborations in West Africa, Asia‐Pacific and the Americas, and spans applied epidemiology and capacity‐building in the field, to genetics and genomics in the lab, to the downstream analytics using advanced approaches and the development of digital tools.
Check out my website for more information: www.shaziaruybal.com
Publications
Journals
Ruybal-Pesántez S, Sáenz FE, Deed SL, et al., 2023, Molecular epidemiology of continued Plasmodium falciparum disease transmission after an outbreak in Ecuador, Frontiers in Tropical Diseases, Vol:4, ISSN:2673-7515, Pages:1-14
Mazhari R, Takashima E, Longley RJ, et al., 2023, Identification of novel Plasmodium vivax proteins associated with protection against clinical malaria, Frontiers in Cellular and Infection Microbiology, Vol:13, ISSN:2235-2988, Pages:1-9
Charnaud S, Munro JE, Semenec L, et al., 2022, PacBio long-read amplicon sequencing enables scalable high-resolution population allele typing of the complex CYP2D6 locus, Communications Biology, Vol:5, Pages:168-168
Ruybal-Pesántez S, Tiedje KE, Pilosof S, et al., 2022, Age-specific patterns of DBLα var diversity can explain why residents of high malaria transmission areas remain susceptible to Plasmodium falciparum blood stage infection throughout life, International Journal for Parasitology, Vol:52, ISSN:0020-7519, Pages:721-731
Tiedje KE, Oduro AR, Bangre O, et al., 2022, Indoor residual spraying with a non-pyrethroid insecticide reduces the reservoir of Plasmodium falciparum in a high-transmission area in northern Ghana, Plos Global Public Health, Vol:2, Pages:e0000285-e0000285