Imperial College London

Dr Sadia Saeed

Faculty of MedicineDepartment of Metabolism, Digestion and Reproduction

Research Associate
 
 
 
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Contact

 

+44 (0)20 7594 6537s.saeed08

 
 
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Location

 

Burlington DanesHammersmith Campus

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Summary

 

Publications

Publication Type
Year
to

19 results found

Saeed S, Arslan M, Manzoor J, Din SM, Janjua QM, Ayesha H, Ain Q-T, Inam L, Lobbens S, Vaillant E, Durand E, Derhourhi M, Amanzougarene S, Badreddine A, Berberian L, Gaget S, Khan WI, Butt TA, Bonnefond A, Froguel Pet al., 2020, Genetic Causes of Severe Childhood Obesity: A Remarkably High Prevalence in an Inbred Population of Pakistan, DIABETES, Vol: 69, Pages: 1424-1438, ISSN: 0012-1797

Journal article

Saeed S, Arslan M, Froguel P, 2018, Genetics of Obesity in Consanguineous Populations: Toward Precision Medicine and the Discovery of Novel Obesity Genes, OBESITY, Vol: 26, Pages: 474-484, ISSN: 1930-7381

Journal article

Saeed S, Bonnefond A, Tamanini F, Mirza MU, Manzoor J, Janjua QM, Din SM, Gaitan J, Milochau A, Durand E, Vaillant E, Haseeb A, De Graeve F, Rabearivelo I, Sand O, Queniat G, Boutry R, Schott DA, Ayesha H, Ali M, Khan WI, Butt TA, Rinne T, Stumpel C, Abderrahmani A, Lang J, Arslan M, Froguel Pet al., 2018, Loss-of-function mutations in ADCY3 cause monogenic severe obesity, NATURE GENETICS, Vol: 50, Pages: 175-179, ISSN: 1061-4036

Study of monogenic forms of obesity has demonstrated the pivotal role of the central leptin–melanocortin pathway in controlling energy balance, appetite and body weight1. The majority of loss-of-function mutations (mostly recessive or co-dominant) have been identified in genes that are directly involved in leptin–melanocortin signaling. These genes, however, only explain obesity in <5% of cases, predominantly from outbred populations2. We previously showed that, in a consanguineous population in Pakistan, recessive mutations in known obesity-related genes explain ~30% of cases with severe obesity3,4,5. These data suggested that new monogenic forms of obesity could also be identified in this population. Here we identify and functionally characterize homozygous mutations in the ADCY3 gene encoding adenylate cyclase 3 in children with severe obesity from consanguineous Pakistani families, as well as compound heterozygous mutations in a severely obese child of European-American descent. These findings highlight ADCY3 as an important mediator of energy homeostasis and an attractive pharmacological target in the treatment of obesity.

Journal article

Saeed S, Bonnefond A, Manzoor J, Shabbir F, Ayesha H, Philippe J, Durand E, Crouch H, Sand O, Ali M, Butt T, Rathore AW, Falchi M, Arslan M, Froguel Pet al., 2017, Genetic Variants in LEP, LEPR, and MC4R Explain 30% of Severe Obesity in Children from a Consanguineous Population (vol 23, pg 1687, 2015), OBESITY, Vol: 25, Pages: 807-807, ISSN: 1930-7381

Journal article

Janjua QM, Shahid A, Alam R, Rizwan M, Saeed S, Qazi MH, Arslan Met al., 2015, Evidence of male hypogonadism at an early age as a familial risk of type 2 diabetes, ANNALES D ENDOCRINOLOGIE, Vol: 76, Pages: 658-663, ISSN: 0003-4266

Journal article

Saeed S, Bonnefond A, Manzoor J, Shabir F, Ayesha H, Philippe J, Durand E, Crouch H, Sand O, Ali M, Butt T, Rathore AW, Falchi M, Arslan M, Froguel Pet al., 2015, Genetic variants in LEP, LEPR, and MC4R explain 30% of severe obesity in children from a consanguineous population, OBESITY, Vol: 23, Pages: 1687-1695, ISSN: 1930-7381

Journal article

Pearce LR, Joe R, Doche ME, Su H-W, Keogh JM, Henning E, Argetsinger LS, Bochukova EG, Cline JM, Garg S, Saeed S, Shoelson S, O'Rahilly S, Barroso I, Rui L, Farooqi IS, Carter-Su Cet al., 2014, Functional Characterization of Obesity-Associated Variants Involving the alpha and beta Isoforms of Human SH2B1, ENDOCRINOLOGY, Vol: 155, Pages: 3219-3226, ISSN: 0013-7227

Journal article

Saeed S, Bonnefond A, Manzoor J, Philippe J, Durand E, Arshad M, Sand O, Butt TA, Falchi M, Arslan M, Froguel Pet al., 2014, Novel LEPR Mutations in Obese Pakistani Children Identified by PCR-Based Enrichment and Next Generation Sequencing, OBESITY, Vol: 22, Pages: 1112-1117, ISSN: 1930-7381

Journal article

Saeed S, Bech PR, Hafeez T, Alam R, Falchi M, Ghatei MA, Bloom SR, Arslan M, Froguel Pet al., 2014, Changes in levels of peripheral hormones controlling appetite are inconsistent with hyperphagia in leptin-deficient subjects, ENDOCRINE, Vol: 45, Pages: 401-408, ISSN: 1355-008X

Journal article

Bonnefond A, Philippe J, Durand E, Muller J, Saeed S, Arslan M, Martinez R, De Graeve F, Dhennin V, Rabearivelo I, Polak M, Cave H, Castano L, Vaxillaire M, Mandel J-L, Sand O, Froguel Pet al., 2014, Highly Sensitive Diagnosis of 43 Monogenic Forms of Diabetes or Obesity Through One-Step PCR-Based Enrichment in Combination With Next-Generation Sequencing, DIABETES CARE, Vol: 37, Pages: 460-467, ISSN: 0149-5992

Journal article

Saeed S, Butt TA, Anwer M, Arslan M, Froguel Pet al., 2013, High prevalence of leptin and melanocotin-4 receptor gene mutations in children with severe obesity from Pakistani consanguineous families (vol 106, pg 121, 2012), MOLECULAR GENETICS AND METABOLISM, Vol: 109, Pages: 404-404, ISSN: 1096-7192

Journal article

Ramachandrappa S, Raimondo A, Cali AMG, Keogh JM, Henning E, Saeed S, Thompson A, Garg S, Bochukova EG, Brage S, Trowse V, Wheeler E, Sullivan AE, Dattani M, Clayton PE, Datta V, Bruning JB, Wareham NJ, O'Rahilly S, Peet DJ, Barroso I, Whitelaw ML, Farooqi ISet al., 2013, Rare variants in single-minded 1 (SIM1) are associated with severe obesity (vol 123, pg 3042, 2013), JOURNAL OF CLINICAL INVESTIGATION, Vol: 123, Pages: 3635-3635, ISSN: 0021-9738

Journal article

Ramachandrappa S, Raimondo A, Cali AMG, Keogh JM, Henning E, Saeed S, Thompson A, Garg S, Bochukova EG, Brage S, Trowse V, Wheeler E, Sullivan AE, Dattani M, Clayton PE, Datta V, Bruning JB, Wareham NJ, O'Rahilly S, Peet DJ, Barroso I, Whitelaw ML, Farooqi ISet al., 2013, Rare variants in single-minded 1 (SIM1) are associated with severe obesity, JOURNAL OF CLINICAL INVESTIGATION, Vol: 123, Pages: 3042-3050, ISSN: 0021-9738

Journal article

Doche ME, Bochukova EG, Su HW, Pearce LR, Keogh JM, Henning E, Cline JM, Saeed S, Dale A, Cheetham T, Barroso I, Argetsinger LS, O'Rahilly S, Rui L, Carter-Su C, Farooqi ISet al., 2013, Erratum: Human SH2B1 mutations are associated with maladaptive behaviors and obesity (Journal of Clinical Investigation (2013) 123:1 (526) DOI: 10.1172/JCI68022), Journal of Clinical Investigation, Vol: 123, ISSN: 0021-9738

Journal article

Doche ME, Bochukova EG, Su H-W, Pearce LR, Keogh JM, Henning E, Cline JM, Dale A, Cheetham T, Barroso I, Argetsinger LS, ORahilly S, Rui L, Carter-Su C, Farooqi ISet al., 2012, Human SH2B1 mutations are associated with maladaptive behaviors and obesity, Journal of Clinical Investigation, Vol: 122, Pages: 4732-4736, ISSN: 0021-9738

Journal article

Saeed S, Butt TA, Anwer M, Arslan M, Froguel Pet al., 2012, High prevalence of leptin and melanocortin-4 receptor gene mutations in children with severe obesity from Pakistani consanguineous families, MOLECULAR GENETICS AND METABOLISM, Vol: 106, Pages: 121-126, ISSN: 1096-7192

Journal article

Shahid A, Saeed S, Saeed S, Alam R, Butt T, Qazi M, Arslan Met al., 2011, EVIDENCE OF HYPOGONADISM AND ITS ASSOCIATION WITH SERUM INSULIN AND LEPTIN LEVELS IN MALE OFFSPRING OF DIABETIC PARENTS, ACTA ENDOCRINOLOGICA-BUCHAREST, Vol: 7, Pages: 365-372, ISSN: 1841-0987

Journal article

Bochukova EG, Huang N, Keogh J, Henning E, Purmann C, Blaszczyk K, Saeed S, Hamilton-Shield J, Clayton-Smith J, O'Rahilly S, Hurles ME, Farooqi ISet al., 2010, Large, rare chromosomal deletions associated with severe early-onset obesity, NATURE, Vol: 463, Pages: 666-670, ISSN: 0028-0836

Journal article

Shahid A, Lone KP, Saeed S, Arslan Met al., 2008, Male offspring of both diabetic parents have higher insulin resistance and serum leptin levels compared to those with one diabetic parent, HORMONES-INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM, Vol: 7, Pages: 313-319, ISSN: 1109-3099

Journal article

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