Summary
Sejal Saglani leads the Paediatric Severe Asthma Group within the Section of Inflammation, Repair and Development and is Honorary Consultant in Paediatric Respiratory Medicine, Royal Brompton Hospital.
She completed her undergraduate degree in medicine at the University of Leicester and undertook her clinical specialist training in Respiratory Paediatrics in the Thames Region. She undertook her postgraduate degree, funded by Asthma UK, at the NHLI investigating the pathology of severe infant and preschool wheeze and received the NHLI Thesis prize for best thesis.
Subsequent to obtaining her clinical specialist training, Prof Saglani obtained a British Lung Foundation Research Fellowship to develop a neonatal mouse model of allergic airways disease, following which she was awarded a Wellcome Intermediate Clinical Fellowship to investigate the mechanisms mediating the onset of preschool wheeze and asthma in early life. She has since been awarded an MRC New Investigator Award, and currently has an NIHR Career Development Fellowship. She was awarded the European Respiratory Society Young Investigator Award for Paediatric Research in 2009, and The European Respiratory Society Romain Pauwels Award for Excellence in Translational Respiratory Research in 2015.
Professor Saglani’s research is focussed on investigating the mechanisms underpinning the onset of severe preschool wheeze, factors predicting progression to school-age asthma and identification of novel therapies for preschool wheeze and childhood severe asthma.
She has established a translational research programme involving an integrated approach using airway samples from children coupled with an age appropriate neonatal mouse model, and direct application and clinical translation of her findings in interventional clinical trials.
Follow me on Twitter @sejalsaglani or more on research from the section and department @lloyd_lab or @ImperialNHLI
Selected Publications
Journal Articles
Bush A, Saglani S, 2020, Medical algorithm: diagnosis and treatment of preschool asthma, Allergy, Vol:75, ISSN:0105-4538, Pages:2711-2712
Nagakumar P, Puttur F, Gregory LG, et al., 2019, Pulmonary type2 innate lymphoid cells in paediatric severe asthma: phenotype and response to steroids, European Respiratory Journal, Vol:54, ISSN:0903-1936, Pages:1-14
Saglani S, Fleming L, Sonnappa S, et al., 2019, Advances in the aetiology, management, and prevention of acute asthma attacks in children, Lancet Child & Adolescent Health, Vol:3, ISSN:2352-4642, Pages:354-364
Robinson PFM, Pattaroni C, Cook J, et al., 2019, Lower airway microbiota associates with inflammatory phenotype in severe preschool wheeze, Journal of Allergy and Clinical Immunology, Vol:143, ISSN:0091-6749, Pages:1607-1610.e
Saglani S, Bush A, Carroll W, et al., 2019, Biologics for paediatric severe asthma: Trick or TREAT?, The Lancet Respiratory Medicine, Vol:7, ISSN:2213-2600, Pages:294-296
Saglani S, Custovic A, 2019, Childhood asthma: Advances using machine learning and mechanistic studies, American Journal of Respiratory and Critical Care Medicine, Vol:199, ISSN:1073-449X
Bush A, Saglani S, 2018, Structurally unsound? Why airways become asthmatic, American Journal of Respiratory Cell and Molecular Biology, Vol:59, ISSN:1044-1549, Pages:405-406
Saglani S, Gregory LG, Manghera AK, et al., 2018, Inception of early life allergen induced airway hyperresponsiveness is reliant on IL-13+CD4+ T cells, Science Immunology, Vol:3, ISSN:2470-9468, Pages:1-12
Saglani S, 2018, Airway granulocytes in severe preschool wheeze: Predictive of school-age asthma attacks or disease protection, Clinical and Experimental Allergy, Vol:48, ISSN:0954-7894, Pages:760-761
Castro-Rodriguez JA, Saglani S, Rodriguez-Martinez CE, et al., 2018, The relationship between inflammation and remodeling in childhood asthma: a systematic review, Pediatric Pulmonology, Vol:53, ISSN:1099-0496, Pages:824-835
Saglani S, Rosenthal M, Bush A, 2018, Should oral corticosteroids be prescribed for preschool viral wheeze?, Lancet Respiratory Medicine, Vol:6, ISSN:2213-2600, Pages:E21-E21
Turner S, Custovic A, Ghazal P, et al., 2018, Pulmonary epithelial barrier and immunological functions at birth and in early life - key determinants of the development of asthma? A description of the protocol for the Breathing Together study [version 1; peer review: 2 approved], Wellcome Open Research, Vol:3, ISSN:2398-502X
Nagakumar P, Gambir N, Sanghani N, et al., 2018, Role of a prolonged inpatient admission when evaluating children with problematic severe asthma., European Respiratory Journal, Vol:51, ISSN:0903-1936
Jochmann A, Artusio L, Jamalzadeh A, et al., 2017, Electronic monitoring of adherence to inhaled corticosteroids: an essential tool in identifying severe asthma in children, European Respiratory Journal, Vol:50, ISSN:0903-1936
Roberts G, Boyle R, Crane J, et al., 2017, Developments in the field of allergy in 2016 through the eyes of Clinical and Experimental Allergy, Clinical and Experimental Allergy, Vol:47, ISSN:0954-7894, Pages:1512-1525
Bush A, Saglani S, Fleming L, 2017, Severe asthma: looking beyond the amount of medication, Lancet Respiratory Medicine, Vol:5, ISSN:2213-2600, Pages:844-846
Alonso AM, Fainardi V, Saglani S, 2017, Severe therapy resistant asthma in children: translational approaches to uncover sub-phenotypes, Expert Review of Respiratory Medicine, Vol:11, ISSN:1747-6348, Pages:867-874
Martin Alonso A, Saglani S, 2017, Mechanisms Mediating Pediatric Severe Asthma and Potential Novel Therapies, Frontiers in Pediatrics, Vol:5, ISSN:2296-2360
Lloyd CM, Saglani S, 2017, Development of allergic immunity in early life, Immunological Reviews, Vol:278, ISSN:0105-2896, Pages:101-115
Saglani S, Bush A, 2017, Asthma attacks in children: does blocking IgE reduce rhinoviral infections?, American Journal of Respiratory and Critical Care Medicine, Vol:196, ISSN:1073-449X, Pages:941-942
Conference
Saglani S, 2018, PRO: Importance of Implementing Asthma Guidelines: An Evidence-Based Approach that Helps Ensure Consistent Management, WILEY, Pages:S26-S28, ISSN:8755-6863
Saglani S, 2018, Pro-Con Debate: Big Data and Multi-omics for Asthma Cure Con: Big Data and Multi-omics Alone Will Not Be Helpful to Cure Asthma: Hypothesis-Driven Mechanistic Research Is Essential, WILEY, Pages:S12-S14, ISSN:8755-6863
Belgrave D, Cassidy R, Custovic A, et al., 2018, Predictive Modelling Strategies to Understand Heterogeneous Manifestations of Asthma in Early Life, 16th IEEE International Conference on Machine Learning and Applications (ICMLA), IEEE, Pages:68-75
Nayeem A, Saglani S, Bush A, et al., 2017, Clinical and pathological characteristics of severely asthmatic children with persistent airflow limitation, Winter Meeting of the British-Thoracic-Society, BMJ Publishing Group, Pages:A45-A46, ISSN:1468-3296
Irving S, Bingham Y, Bossley C, et al., 2017, Change in lung clearance index and exhaled nitric oxide as markers of systemic corticosteroid response in children with severe asthma, Winter Meeting of the British-Thoracic-Society, BMJ Publishing Group, Pages:A44-A45, ISSN:1468-3296
Wells C, Collins N, Bush A, et al., 2017, BENCHMARKING OF PAEDIATRIC DIFFICULT ASTHMA PHYSIOTHERAPY SERVICES, Winter Meeting of the British-Thoracic-Society, BMJ PUBLISHING GROUP, Pages:A130-A130, ISSN:0040-6376
Bingham Y, Sanghani N, Irving S, et al., 2017, RELATIONSHIP BETWEEN EXHALED NITRIC OXIDE AND LUNG CLEARANCE INDEX IN PRE-SCHOOL CHILDREN WITH A RANGE OF RESPIRATORY SYMPTOMS, Winter Meeting of the British-Thoracic-Society, BMJ PUBLISHING GROUP, Pages:A131-A131, ISSN:0040-6376