Publications
297 results found
Saglani S, Bush A, 2008, Asthma, atopy, and airway inflammation - What does it mean in practice?, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 178, Pages: 437-438, ISSN: 1073-449X
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- Citations: 6
Regamey N, Ochs M, Hilliard TN, et al., 2008, Increased airway smooth muscle mass in children with asthma, cystic fibrosis, and non-cystic fibrosis bronchiectasis, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 177, Pages: 837-843, ISSN: 1073-449X
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- Citations: 128
Regamey N, Hilliard TN, Saglani S, et al., 2008, Endobronchial biopsy in childhood, CHEST, Vol: 133, Pages: 312-312, ISSN: 0012-3692
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- Citations: 3
Sonnappa S, Bastardo C, Saglani S, et al., 2007, Do lung function tests at 4-6 years of age in severe preschool wheezers correlate with endobronchial biopsy in early preschool years?, Winter Meeting of the British-Thoracic-Society, Publisher: B M J PUBLISHING GROUP, Pages: A39-A39, ISSN: 0040-6376
Saglani S, Payne DN, Zhu J, et al., 2007, Early detection of airway wall remodeling and eosinophilic inflammation in preschool wheezers, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 176, Pages: 858-864, ISSN: 1073-449X
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- Citations: 363
Thompson N, Saglani S, Bush A, 2007, An infant with pneumonia, failure to thrive and persistent radiographical changes, EUROPEAN RESPIRATORY JOURNAL, Vol: 30, Pages: 172-176, ISSN: 0903-1936
Regamey N, Hilliard TN, Saglani S, et al., 2007, Quality, size, and composition of pediatric endobronchial biopsies in cystic fibrosis, CHEST, Vol: 131, Pages: 1710-1717, ISSN: 0012-3692
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- Citations: 27
Saglani S, Wilson N, Bush A, 2007, Should preschool wheezers ever be treated with inhaled cortico steroids?, SEMINARS IN RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 28, Pages: 272-285, ISSN: 1069-3424
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- Citations: 8
Saglani S, Bush A, 2007, The early-life origins of asthma, CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY, Vol: 7, Pages: 83-90, ISSN: 1528-4050
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- Citations: 40
Regamey N, Ochs M, Hilliard TN, et al., 2007, Airway smooth muscle remodeling in children with cystic fibrosis, PEDIATRIC PULMONOLOGY, Pages: 349-350, ISSN: 8755-6863
Molina-Teran A, Hilliard TN, Saglani S, et al., 2006, Safety of endobronchial biopsy in children with cystic fibrosis, PEDIATRIC PULMONOLOGY, Vol: 41, Pages: 1021-1024, ISSN: 8755-6863
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- Citations: 26
Saglani S, Molyneux C, Gong H, et al., 2006, Ultrastructure of the reticular basement membrane in asthmatic adults, children and infants, EUROPEAN RESPIRATORY JOURNAL, Vol: 28, Pages: 505-512, ISSN: 0903-1936
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- Citations: 51
Saglani S, Papaioannou G, Khoo L, et al., 2006, Can HRCT be used as a marker of airway remodelling in children with difficult asthma?, Respiratory Research, Vol: 7, ISSN: 1465-993X
Background: Whole airway wall thickening on high resolution computed tomography (HRCT) isreported to parallel thickening of the bronchial epithelial reticular basement membrane (RBM) inadult asthmatics. A similar relationship in children with difficult asthma (DA), in whom RBMthickening is a known feature, may allow the use of HRCT as a non-invasive marker of airwayremodelling. We evaluated this relationship in children with DA.Methods: 27 children (median age 10.5 [range 4.1–16.7] years) with DA, underwentendobronchial biopsy from the right lower lobe and HRCT less than 4 months apart. HRCTs wereassessed for bronchial wall thickening (BWT) of the right lower lobe using semi-quantitative andquantitative scoring techniques. The semi-quantitative score (grade 0–4) was an overall assessmentof BWT of all clearly identifiable airways in HRCT scans. The quantitative score (BWT %; definedas [airway outer diameter – airway lumen diameter]/airway outer diameter ×100) was the averagescore of all airways visible and calculated using electronic endpoint callipers. RBM thickness inendobronchial biopsies was measured using image analysis. 23/27 subjects performed spirometryand the relationships between RBM thickness and BWT with airflow obstruction evaluated.Results: Median RBM thickness in endobronchial biopsies was 6.7(range 4.6 – 10.0) µm. Medianqualitative score for BWT of the right lower lobe was 1(range 0 – 1.5) and quantitative score was54.3 (range 48.2 – 65.6)%. There was no relationship between RBM thickness and BWT in the rightlower lobe using either scoring technique. No relationship was found between FEV1 and BWT orRBM thickness.Conclusion: Although a relationship between RBM thickness and BWT on HRCT has been foundin adults with asthma, this relationship does not appear to hold true in children with DA.
Saglani S, Nicholson AG, Scallan M, et al., 2006, Investigation of young children with severe recurrent wheeze: any clinical benefit?, EUROPEAN RESPIRATORY JOURNAL, Vol: 27, Pages: 29-35, ISSN: 0903-1936
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- Citations: 67
Payne DN, Saglani S, Bush A, 2006, Remodelling in paediatric respiratory disease and impact on growth and development, RESPIRATORY DISEASES IN INFANTS AND CHILDREN, Editors: Frey, Gerritsen, Publisher: EUROPEAN RESPIRATORY SOCIETY, Pages: 41-59
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- Citations: 2
Saglani S, Payne DN, Nicholson AG, et al., 2005, The pathology of severe preschool wheeze, Winter Meeting of the British-Thoracic-Society, Publisher: B M J PUBLISHING GROUP, Pages: II5-II5, ISSN: 0040-6376
Saglani S, McKenzie SA, Bush A, et al., 2005, A video questionnaire identifies upper airway abnormalities in preschool children with reported wheeze, ARCHIVES OF DISEASE IN CHILDHOOD, Vol: 90, Pages: 961-964, ISSN: 0003-9888
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- Citations: 38
Saglani S, Malmstrôm K, Pelkonen AS, et al., 2005, Airway remodeling and inflammation in symptomatic infants with reversible airflow obstruction, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 171, Pages: 722-727, ISSN: 1073-449X
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- Citations: 282
Saglani S, Harris KA, Wallis C, et al., 2005, Empyema: the use of broad range 16S rDNA PCR for pathogen detection, ARCHIVES OF DISEASE IN CHILDHOOD, Vol: 90, Pages: 70-73, ISSN: 0003-9888
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- Citations: 75
Saglani S, Payne DNR, Nicholson AG, et al., 2004, Thickening of the epithelial reticular basement membrane in preschool children with troublesome wheeze, Winter Meeting of the British-Thoracic-Society, Publisher: B M J PUBLISHING GROUP, Pages: 19-20, ISSN: 0040-6376
Saglani S, Lenney W, 2004, Difficult asthma in the pre-school child., Paediatr Respir Rev, Vol: 5, Pages: 199-206, ISSN: 1526-0542
The most important aspect of dealing with a pre-school child suspected of having difficult asthma, is to ensure that the diagnosis is correct, in order to avoid the inappropriate use of therapies such as inhaled corticosteroids. After exclusion of other diagnoses, if a pre-school child is thought to have asthma, difficult or otherwise, the corollary is, what sort of asthma? Is it a syndrome with airway inflammation susceptible to treatment, or one in which there is no inflammation and time alone will result in resolution of symptoms? Probably the most common mistake in this age group is to fail to recognise the latter and institute ever more aggressive and useless therapies. An approach to excluding other diagnoses, appropriate investigations to elicit the presence of airway inflammation and suggestions for subsequent management have been detailed in this review.
Saglani S, Payne DNR, Nicholson AG, et al., 2003, The safety and quality of endobronchial biopsy in children under five years old, THORAX, Vol: 58, Pages: 1053-1057, ISSN: 0040-6376
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- Citations: 32
Saglani S, Payne DNR, McKenzie SA, et al., 2003, Relationship between parental reported wheeze, video questionnaire and bronchoscopy findings in pre-school children with troublesome respiratory symptoms, Winter Meeting of the British Thoracic-Society, Publisher: B M J PUBLISHING GROUP, Pages: 12-12, ISSN: 0040-6376
Cohen G, Saglani S, Dinwiddie R, et al., 2003, An alternative to lung transplantation., Pediatr Pulmonol, Vol: 36, Pages: 357-358, ISSN: 8755-6863
Lung volume reduction surgery (LVRS) has been used increasingly in adults for treatment of breathlessness caused by severe emphysema.1 It is of particular benefit to patients with a heterogenous anatomic distribution of emphysema, with obvious target areas for resection,2 as it allows an improved chance of reclaiming function from surrounding compressed lung.3 We report on an 8-year-old male with obliterative bronchiolitis in whom LVRS has been used as a measure to significantly improve quality of life and avoid the immediate need for lung transplantation.
Roberts G, Newsom D, Gomez K, et al., 2003, Intravenous salbutamol bolus compared with an aminophylline infusion in children with severe asthma: a randomised controlled trial, THORAX, Vol: 58, Pages: 306-310, ISSN: 0040-6376
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- Citations: 51
Saglani S, McKenzie SA, 2002, Environmental factors relevant to difficult asthma., Paediatr Respir Rev, Vol: 3, Pages: 248-254, ISSN: 1526-0542
Symptom persistence in difficult asthmatics may be related to their home environment. If sensitised asthmatics are to benefit from indoor allergen avoidance measures, these must be rigorous and drug adherence satisfactory. This is difficult for many families. The relationship between traffic pollution, asthma diagnosis and symptom severity is persuasive but requires objective validation. Overall, it seems that house dust mite control and tobacco smoke avoidance are important for asthmatics and advice about how to avoid these adverse factors must be given. Whether these measures are effective in difficult asthmatics and whether moving house makes any difference is unknown.
Saglani S, Bush A, 2001, Cystic fibrosis and Down's syndrome: not always a poor prognosis., Pediatr Pulmonol, Vol: 31, Pages: 321-322, ISSN: 8755-6863
A child developed a bronchiolitis-like illness and was found to have mosaic Down's syndrome (diagnosed on karyotype) and also cystic fibrosis, diagnosed on the basis of a high sweat osmolality (247 mosmoles/kg sweat; normal, 62-137) and a homozygous delta F508 genotype. Despite two potentially life-threatening conditions, the child is doing well at the age of 7 years, despite pancreatic insufficiency.
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