Imperial College London
Alternate

ProfessorSejalSaglani

Faculty of Medicine, National Heart & Lung Institute

Professor of Paediatric Respiratory Medicine
 
 
 
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Contact

 

+44 (0)20 7594 3167s.saglani

 
 
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Location

 

112Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@inbook{Saglani:2019:10.1016/B978-0-323-44887-1.00043-2,
author = {Saglani, S and Lloyd, CM},
booktitle = {Kendig's Disorders of the Respiratory Tract in Children},
doi = {10.1016/B978-0-323-44887-1.00043-2},
pages = {665--676.e3},
title = {43 - The Immunopathogenesis of Asthma},
url = {http://dx.doi.org/10.1016/B978-0-323-44887-1.00043-2},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - CHAP
AB  - Asthma occurs as a result of the interplay of genetic susceptibility and environmental influences on the developing lungs and immune system. Asthma in children is predominantly associated with the development of allergic sensitization and the pathological features of eosinophilic airway inflammation and structural airway wall changes, collectively termed airway remodeling. The clinical manifestation of disease is heterogeneous but includes symptoms of breathlessness and wheeze, which result from bronchoconstriction. Acute attacks in children commonly result from respiratory infection, with repeated episodes of infection with rhinovirus and respiratory syncytial virus in early life being especially associated with the risk of recurrent wheezing and asthma in children who also develop early allergic sensitization and have a genetic susceptibility. The focus of this chapter is to discuss the basic immunological mechanisms that drive the pathophysiology of asthma, with specific focus on the close interactions between innate and adaptive immune responses in driving disease. The immunopathology of specific clinical manifestations of disease, including exacerbations and preschool wheezing disorders, will also be discussed, and mechanisms that are unique to the developing pediatric airway and that cannot be extrapolated from adult disease will be highlighted.
AU  - Saglani,S
AU  - Lloyd,CM
DO  - 10.1016/B978-0-323-44887-1.00043-2
EP  - 676
PY  - 2019///
SN  - 9780323448871
SP  - 665
TI  - 43 - The Immunopathogenesis of Asthma
T1  - Kendig's Disorders of the Respiratory Tract in Children
UR  - http://dx.doi.org/10.1016/B978-0-323-44887-1.00043-2
ER  -
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