Imperial College London
Alternate

ProfessorSejalSaglani

Faculty of Medicine, National Heart & Lung Institute

Professor of Paediatric Respiratory Medicine
 
 
 
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Contact

 

+44 (0)20 7594 3167s.saglani

 
 
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Location

 

112Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Bloom:2021:10.1016/j.jaci.2020.12.643,
author = {Bloom, C and Franklin, C and Bush, A and Saglani, S and Quint, J},
doi = {10.1016/j.jaci.2020.12.643},
journal = {Journal of Allergy and Clinical Immunology},
pages = {1949--1958},
title = {Burden of preschool wheeze and progression to asthma in the UK: population-based cohort 2007 to 2017},
url = {http://dx.doi.org/10.1016/j.jaci.2020.12.643},
volume = {147},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BackgroundWheeze is one of the most common symptoms of preschool children (age 1 to 5 years), yet we have little understanding of the burden in the UK.ObjectivesDetermine prevalence and pattern of physician-confirmed preschool wheeze, related healthcare utilisation, and factors associated with progression to school-age asthma.MethodsWe used nationally representative primary and secondary care electronic medical records between 2007-2017 to identify preschool children with wheeze. Factors associated with asthma progression were identified in a nested cohort of children with follow-up from 1-2 years of age, until at least 8 years of age.ResultsFrom 1,021,624 preschool children, 69,261 were identified with wheeze. Prevalence of preschool wheeze was 7.7% in 2017. Wheeze events were lowest in August and highest in late-autumn/early-winter. During median follow-up of 2.0 years (IQR 1.2-4.0), 15.8% attended an emergency department, and 13.9% had a hospital admission, for a respiratory disorder. The nested cohort with prolonged follow-up identified 15,085 children; 35.5% progressed to asthma between 5-8 years old. Of children with preschool wheeze, without an asthma diagnosis, 34.9% were prescribed inhaled corticosteroids, and 15.6% oral corticosteroids. The factors most strongly associated with progression to asthma were wheeze frequency and severity, atopy, prematurity, maternal asthma severity and first reported wheeze event occurring in September.ConclusionsPreschool wheeze causes considerable healthcare burden, a large number of children are prescribed asthma medication and have unplanned secondary care visits. Multiple factors influence progression to asthma, including first wheeze event occurring in September.
AU  - Bloom,C
AU  - Franklin,C
AU  - Bush,A
AU  - Saglani,S
AU  - Quint,J
DO  - 10.1016/j.jaci.2020.12.643
EP  - 1958
PY  - 2021///
SN  - 0091-6749
SP  - 1949
TI  - Burden of preschool wheeze and progression to asthma in the UK: population-based cohort 2007 to 2017
T2  - Journal of Allergy and Clinical Immunology
UR  - http://dx.doi.org/10.1016/j.jaci.2020.12.643
UR  - https://www.sciencedirect.com/science/article/pii/S0091674921000063?via%3Dihub
UR  - http://hdl.handle.net/10044/1/84994
VL  - 147
ER  -
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