Imperial College London
Alternate

ProfessorSejalSaglani

Faculty of Medicine, National Heart & Lung Institute

Professor of Paediatric Respiratory Medicine
 
 
 
//

Contact

 

+44 (0)20 7594 3167s.saglani

 
 
//

Location

 

112Sir Alexander Fleming BuildingSouth Kensington Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Saglani:2021:10.1080/17476348.2021.1913057,
author = {Saglani, S and Scotney, E and Bonner, K},
doi = {10.1080/17476348.2021.1913057},
journal = {Expert Review of Respiratory Medicine},
pages = {745--760},
title = {Factors and Mechanisms contributing to the development of preschool wheezing disorders},
url = {http://dx.doi.org/10.1080/17476348.2021.1913057},
volume = {15},
year = {2021}
}
Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - IntroductionHalf of all children will experience an episode of wheezing by their sixth birthday and acute episodes of wheezing in preschool children account for the majority of all childhood hospital admissions for wheeze. Recurrent preschool wheezing associates with early loss of lung function and a life-long impact on lung health.Areas coveredWe reviewed the literature on PubMed from August 2010–2020 focussing on factors associated with wheeze inception and persistence, paying specific attention to mechanistic studies that have investigated the impact of early life exposures in shaping immune responses in children with underlying susceptibility to wheezing. In particular, the role of early allergen sensitization, respiratory infections, and the impact of the environment on shaping the airway microbiome and resulting immune responses are discussed.Expert opinionThere is an abundance of associative data showing the role of in utero and postnatal factors influencing wheeze onset and persistence. However, mechanistic and stratified, biomarker-based interventional studies that confirm these associations are now needed if we are to impact the significant healthcare burden resulting from preschool wheezing disorders.
AU  - Saglani,S
AU  - Scotney,E
AU  - Bonner,K
DO  - 10.1080/17476348.2021.1913057
EP  - 760
PY  - 2021///
SN  - 1747-6348
SP  - 745
TI  - Factors and Mechanisms contributing to the development of preschool wheezing disorders
T2  - Expert Review of Respiratory Medicine
UR  - http://dx.doi.org/10.1080/17476348.2021.1913057
UR  - https://www.tandfonline.com/doi/full/10.1080/17476348.2021.1913057
UR  - http://hdl.handle.net/10044/1/89166
VL  - 15
ER  -
Download