Imperial College London
Alternate

ProfessorSejalSaglani

Faculty of Medicine, National Heart & Lung Institute

Professor of Paediatric Respiratory Medicine
 
 
 
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Contact

 

+44 (0)20 7594 3167s.saglani

 
 
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Location

 

112Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Pattaroni:2022:10.1186/s40168-021-01201-y,
author = {Pattaroni, C and Macowan, M and Chatzis, R and Daunt, C and Custovic, A and Shields, MD and Power, UF and Grigg, J and Roberts, G and Ghazal, P and Schwarze, J and Gore, M and Turner, S and Bush, A and Saglani, S and Lloyd, C and Marsland, BJ},
doi = {10.1186/s40168-021-01201-y},
journal = {Microbiome},
title = {Early life inter-kingdom interactions shape the immunological environment of the airways},
url = {http://dx.doi.org/10.1186/s40168-021-01201-y},
volume = {10},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Background: There is increasing evidence that the airway microbiome plays a key role in the establishment of respiratory health by interacting with the developing immune system early in life. While it has become clear that bacteria are involved in this process, there is a knowledge gap concerning the role of fungi. Moreover, the inter-kingdom interactions that influence immune development remain unknown. In this prospective exploratory human study, we aimed to determine early post-natal microbial and immunological features of the upper airways in 121 healthy newborns.Results: We found that the oropharynx and nasal cavity represent distinct ecological niches for bacteria and fungi. Breastfeeding correlated with changes in microbiota composition of oropharyngeal samples with the greatest impact upon the relative abundance of Streptococcus species and Candida. Host transcriptome profiling revealed that genes with the highest expression variation were immunological in nature. Multi-omics factor analysis of host and microbial data revealed unique co-variation patterns. Conclusion: These data provide evidence of a diverse multi-kingdom microbiota linked with local immunological characteristics in the first week of life that could represent distinct trajectories for future respiratory health.
AU  - Pattaroni,C
AU  - Macowan,M
AU  - Chatzis,R
AU  - Daunt,C
AU  - Custovic,A
AU  - Shields,MD
AU  - Power,UF
AU  - Grigg,J
AU  - Roberts,G
AU  - Ghazal,P
AU  - Schwarze,J
AU  - Gore,M
AU  - Turner,S
AU  - Bush,A
AU  - Saglani,S
AU  - Lloyd,C
AU  - Marsland,BJ
DO  - 10.1186/s40168-021-01201-y
PY  - 2022///
SN  - 2049-2618
TI  - Early life inter-kingdom interactions shape the immunological environment of the airways
T2  - Microbiome
UR  - http://dx.doi.org/10.1186/s40168-021-01201-y
UR  - https://microbiomejournal.biomedcentral.com/articles/10.1186/s40168-021-01201-y
UR  - http://hdl.handle.net/10044/1/93911
VL  - 10
ER  -
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