Publications
44 results found
Schelenz S, Ross CN, 2006, Limitations of caspofungin in the treatment of obstructive pyonephrosis due to Candida glabrata infection., BMC Infectious Diseases, Vol: 6, ISSN: 1471-2334
BACKGROUND: Caspofungin is a new antifungal agent with high-level activity against a number of Candida species including those that are resistant to azoles. Its good safety profile and low nephrotoxicity makes it an attractive drug to treat fungal infections in patients with compromised renal function. However, little is known about the clinical efficacy in the treatment of complicated urinary tract infections due to Candida species such as pyonephrosis. CASE PRESENTATION: We report a case of obstructive pyonephrosis due to an azole (fluconazole and itraconazole) resistant Candida glabrata strain that failed to respond to intravenous treatment with caspofungin. A sustained clinical and microbiological response was only achieved after percutaneous drainage and instillation of amphotericin B deoxycholate into the renal pelvis in combination with intravenous liposomal amphotericin B. CONCLUSION: This case demonstrates the limitation of intravenous antifungal agents such as caspofungin as the sole treatment of an obstructive upper urinary tract infection due to Candida species. In order to achieve long term sustained cure from an obstructive pyonephrosis, pus and fungal balls should be drained and an anti-fungal agent such as amphotericin B deoxycholate instilled locally. The pharmacokinetics and role of caspofungin in the treatment of complicated Candida urinary tract infection is reviewed.
Schelenz S, Page AJF, Emmerson AM, 2005, <i>Streptococcus mutans</i> endocarditis:: beware of the 'diphtheroid', JOURNAL OF THE ROYAL SOCIETY OF MEDICINE, Vol: 98, Pages: 420-421, ISSN: 0141-0768
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- Citations: 5
Schelenz S, Watson N, 2005, Diagnosis and treatment of fungal endophthalmitis: A reassessment, CLINICAL INFECTIOUS DISEASES, Vol: 41, Pages: 274-275, ISSN: 1058-4838
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- Citations: 2
Schelenz S, Tucker P, Georgeu C, et al., 2005, Significant reduction of endemic MRSA acquisition and infection in cardiothoracic patients by means of an enhanced targeted infection control programme, JOURNAL OF HOSPITAL INFECTION, Vol: 60, Pages: 104-110, ISSN: 0195-6701
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- Citations: 45
Schweigart JH, Klotsas A, Schelenz S, et al., 2005, Portal vein thrombosis despite anticoagulation in a person with diabetes, JOURNAL OF THE ROYAL SOCIETY OF MEDICINE, Vol: 98, Pages: 161-163, ISSN: 0141-0768
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- Citations: 9
Schelenz S, Goldsmith DJA, 2003, <i>Aspergillus</i> endophthalmitis:: an unusual complication of disseminated infection in renal transplant patients, JOURNAL OF INFECTION, Vol: 47, Pages: 336-343, ISSN: 0163-4453
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- Citations: 33
Schelenz S, Gransden WR, 2003, Candidaemia in a London teaching hospital: analysis of 128 cases over a 7-year period, MYCOSES, Vol: 46, Pages: 390-396, ISSN: 0933-7407
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- Citations: 40
Doulton T, Sabharwal N, Cairns HS, et al., 2003, Infective endocarditis in dialysis patients: New challenges and old, KIDNEY INTERNATIONAL, Vol: 64, Pages: 720-727, ISSN: 0085-2538
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- Citations: 74
Schelenz S, French G, 2000, An outbreak of multidrug-resistant <i>Pseudomonas aeruginosa</i> infection associated with contamination of bronchoscopes and an endoscope washer-disinfector, JOURNAL OF HOSPITAL INFECTION, Vol: 46, Pages: 23-30, ISSN: 0195-6701
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- Citations: 57
Schelenz S, 2000, Argentina - British infection control experience, JOURNAL OF HOSPITAL INFECTION, Vol: 44, Pages: 316-317, ISSN: 0195-6701
Schelenz S, 2000, Hospital Infection Society International Activities. Argentina - British infection control experience., J Hosp Infect, Vol: 44, Pages: 317-318, ISSN: 0195-6701
Schelenz S, Smith DA, Bancroft GJ, 1999, Cytokine and chemokine responses following pulmonary challenge with <i>Aspergillus fumigatus</i>:: obligatory role of TNF-α and GM-CSF in neutrophil recruitment, MEDICAL MYCOLOGY, Vol: 37, Pages: 183-194, ISSN: 1369-3786
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- Citations: 77
Schelenz S, 1997, Mechanism of innate resistance in the lung in response to fungal pathogens
SCHELENZ S, MALHOTRA R, SIM RB, et al., 1995, BINDING OF HOST COLLECTINS TO THE PATHOGENIC YEAST CRYPTOCOCCUS-NEOFORMANS - HUMAN SURFACTANT PROTEIN-D ACTS AS AN AGGLUTININ FOR ACAPSULAR YEAST-CELLS, INFECTION AND IMMUNITY, Vol: 63, Pages: 3360-3366, ISSN: 0019-9567
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- Citations: 114
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