Imperial College London
Dr Silke Schelenz

DrSilkeSchelenz

Faculty of Medicine, National Heart & Lung Institute

Honorary Clinical Senior Lecturer
 
 
 
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Contact

 

s.schelenz

 
 
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Location

 

Guy Scadding BuildingRoyal Brompton Campus

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Summary

 

Publications

Citation

BibTex format

@article{Ruiz:2019:10.1007/s00294-019-00976-w,
author = {Ruiz, GB and Ross, ZK and Holmes, E and Schelenz, S and Gow, NAR and Lorenz, A},
doi = {10.1007/s00294-019-00976-w},
journal = {Current Genetics},
pages = {1217--1228},
title = {Rapid and extensive karyotype diversification in haploid clinical Candida auris isolates},
url = {http://dx.doi.org/10.1007/s00294-019-00976-w},
volume = {65},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Candida auris is a newly emerged pathogenic microbe, having been identified as a medically relevant fungus as recently as 2009. It is one of the most drug-resistant yeast species known to date and its emergence and population structure are unusual. Because of its recent emergence, we are largely ignorant about fundamental aspects of its general biology, life cycle, and population dynamics. Here, we report the karyotype variability of 26 C. auris strains representing the four main clades. We demonstrate that all strains are haploid and have a highly plastic karyotype containing five to seven chromosomes, which can undergo marked alterations within a short time frame when the fungus is put under genotoxic, heat, or osmotic stress. No simple correlation was found between karyotype pattern, drug resistance, and clade affiliation indicating that karyotype heterogeneity is rapidly evolving. As with other Candida species, these marked karyotype differences between isolates are likely to have an important impact on pathogenic traits of C. auris.
AU  - Ruiz,GB
AU  - Ross,ZK
AU  - Holmes,E
AU  - Schelenz,S
AU  - Gow,NAR
AU  - Lorenz,A
DO  - 10.1007/s00294-019-00976-w
EP  - 1228
PY  - 2019///
SN  - 0172-8083
SP  - 1217
TI  - Rapid and extensive karyotype diversification in haploid clinical Candida auris isolates
T2  - Current Genetics
UR  - http://dx.doi.org/10.1007/s00294-019-00976-w
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000485990000017&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/74033
VL  - 65
ER  -
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