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@article{Jones:2014:10.1136/oemed-2014-102119,
author = {Jones, M and Jeal, H and Schofield, S and Harris, JM and Shamji, MH and Francis, JN and Durham, SR and Cullinan, P},
doi = {10.1136/oemed-2014-102119},
journal = {Occupational and Environmental Medicine},
pages = {619--623},
title = {Rat-specific IgG and IgG(4) antibodies associated with inhibition of IgE-allergen complex binding in laboratory animal workers},
url = {http://dx.doi.org/10.1136/oemed-2014-102119},
volume = {71},
year = {2014}
}

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TY  - JOUR
AB  - Objectives The relationship between exposure torodent allergens and laboratory animal allergy iscomplex; at highest allergen exposures there is anattenuation of sensitisation and symptoms which areassociated with increased levels of rat-specificimmunoglobulin (Ig)G and IgG4 antibodies. We set outto examine whether the increased levels of rat-specificIgG and IgG4 antibodies that we have previouslyobserved at high allergen exposure in our cohort oflaboratory animal workers play a functional role throughblockage of the binding of IgE–allergen complex bindingto CD23 receptors on B cells.Methods Cross-sectional survey of laboratory animalworkers (n=776) in six UK pharmaceutical companieswere surveyed. IgE–allergen complex binding to B cellswas measured in 703 (97.9%) eligible employees; theirexposure was categorised by either job group or numberof rats handled daily.Results We observed a significant decrease inIgE–allergen complex binding to B cells with increasingquartiles of both rat-specific IgG and IgG4 antibodies(p<0.001). IgE–allergen complex binding to B cells waslower in workers with high allergen exposure, andsignificantly so (p=0.033) in the subgroup with highestexposures but no work-related chest symptoms.Conclusions These findings demonstrate a functionalrole for rat-specific IgG/G4 antibodies in laboratoryanimal workers, similar to that observed in patientstreated with high dose immunotherapy who becomeclinically tolerant, suggesting a potential explanation forthe attenuation of risk at highest allergen exposures.
AU  - Jones,M
AU  - Jeal,H
AU  - Schofield,S
AU  - Harris,JM
AU  - Shamji,MH
AU  - Francis,JN
AU  - Durham,SR
AU  - Cullinan,P
DO  - 10.1136/oemed-2014-102119
EP  - 623
PY  - 2014///
SN  - 1470-7926
SP  - 619
TI  - Rat-specific IgG and IgG(4) antibodies associated with inhibition of IgE-allergen complex binding in laboratory animal workers
T2  - Occupational and Environmental Medicine
UR  - http://dx.doi.org/10.1136/oemed-2014-102119
UR  - http://hdl.handle.net/10044/1/27303
VL  - 71
ER  -

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